GPCRs – “Profiling the pharmacology of GPCRs by time-resolved impedance measurements”

This Application Note demonstrates the in vitro characterization of GPCR pharmacology, covering agonist and antagonist mode of action, dose-response relationships, and the involvement of signal transduction cascades. Experimentally, cells expressing H1R or Y4R are cultured on planar gold-film electrodes integrated into standard cell culture dishes.