SyncroPatch 384 – Prof. Dr. Jamie Vandenberg

In my lab we use the SyncroPatch 384PE, as it allows us to reliably screen KCNH2 mutations, the gene encoding hERG K⁺ channels, in high-throughput. This is a very fast process and it enables us to screen large mutation libraries. Recently, we have validated a high-throughput functional phenotyping assay capable of distinguishing benign KCNH2 variants from those that have a dominant negative effect, using the SyncroPatch 384PE. We are very happy with this result and plan to expand assay development to other ion channel genes.