Overall the Patchliner is a high-quality machine supported by high-quality people! The Patchliner comes with robust and high-quality Heka amplifiers. Therefore a previous knowledge of the Heka software is clearly helpful. Nevertheless, for the people that are not familiar with the Heka software, Nanion Patchliner created their own software, with a more friendly user interface, to control the Heka commands. Overall it is easy to use. The Patchliner offers the possibility to measure up to 8 cells simultaneously (some cells are “easier” than other though and the success rate can vary accordingly). The solutions are directly applied by the Patchliner “Syringe Pipettor”. The speed of the solution application can be modified and the protocols are very flexible and easy to set up. Results are very reproducible. It allows the recording of all types of ion channels (including mechanosensitive channels!). In addition, the Patchliner support team is incredible to help you anytime on short notice!