{"id":6735,"date":"2023-02-17T06:58:38","date_gmt":"2023-02-17T06:58:38","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/asic3-characterization-of-hasic3-hek-on-nanions-patchliner\/"},"modified":"2023-02-17T06:58:38","modified_gmt":"2023-02-17T06:58:38","slug":"asic3-characterization-of-hasic3-hek-on-nanions-patchliner","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/asic3-characterization-of-hasic3-hek-on-nanions-patchliner\/","title":{"rendered":"ASIC3 &#8211; &#8220;Characterization of hASIC3 (HEK) on Nanion\u00b4s Patchliner&#8221;"},"content":{"rendered":"<p>Acid-sensing ion channels (ASICs) are ligand-gated ion\u00a0channels activated by protons and are members of\u00a0the sodium-selective cation channels belonging to the\u00a0epithelial sodium channel\/degenerin (ENaC\/DEG)\u00a0family. They are highly sensitive to extracellular acidosis.\u00a0In rodents, where they are mainly expressed in\u00a0neurons of the peripheral nervous system, ASIC3 plays\u00a0an important role as sensor of non-adaptive pain which\u00a0is correlated to tissue acidosis. However, the role of the\u00a0human ASIC3 channel has not yet been elucidated.\u00a0In contrast to other ASIC ion channels, ASIC3 shows a\u00a0sustained window current upon external acidification.\u00a0Here we present data recorded on an 8-channel\u00a0Patchliner. Current responses upon external acidification\u00a0as well as amiloride block of acidosis-induced currents of\u00a0hASIC3-expressing HEK293 cells are shown.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55,56],"target_categories":[337],"target_families":[368],"targets":[105],"resource_keyword":[],"class_list":["post-6735","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","therapeutic_areas-pain","target_categories-ligand-gated-ion-channels","target_families-asic-channels","targets-asic3"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/6735","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=6735"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=6735"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=6735"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=6735"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=6735"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=6735"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=6735"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=6735"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=6735"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}