{"id":4757,"date":"2023-02-17T07:06:03","date_gmt":"2023-02-17T07:06:03","guid":{"rendered":"http:\/\/ionchanneltargets.com\/resource_library\/nav1-8-characterization-of-rnav1-8-nd7-23-on-nanions-patchliner\/"},"modified":"2023-02-17T07:06:03","modified_gmt":"2023-02-17T07:06:03","slug":"2009-amyloid-beta-induced-ion-flux-in-artificial-lipid-bilayers-and-neuronal-cells-resolving-a-controversy","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/2009-amyloid-beta-induced-ion-flux-in-artificial-lipid-bilayers-and-neuronal-cells-resolving-a-controversy\/","title":{"rendered":"2009 &#8211; Amyloid-beta-Induced Ion Flux in Artificial Lipid Bilayers and Neuronal Cells: Resolving a Controversy"},"content":{"rendered":"<p>Understanding the pathogenicity of amyloid-beta (A\u03b2) peptides constitutes a major goal in research on Alzheimer\u2019s disease (AD). One hypothesis entails that A\u03b2 peptides induce uncontrolled, neurotoxic ion flux through cellular membranes. The exact biophysical mechanism of this ion flux is, however, a subject of an ongoing controversy which has attenuated progress toward understanding the importance of A\u03b2-induced ion flux in AD. The work presented here addresses two prevalent controversies regarding the nature of transmembrane ion flux induced by \u0391\u03b2 peptides. First, the results clarify that \u0391\u03b2 can induce stepwise ion flux across planar lipid bilayers as opposed to a gradual increase in transmembrane current; they show that the previously reported gradual thinning of membranes with concomitant increase in transmembrane current arises from residues of the solvent hexafluoroisopropanol, which is commonly used for the preparation of amyloid samples. Second, the results provide additional evidence suggesting that A\u03b2 peptides can induce ion channel-like ion flux in cellular membranes that is independent from the postulated ability of \u0391\u03b2 to modulate intrinsic cellular ion channels or transporter proteins.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45,129],"resource_type":[75],"application_areas":[],"therapeutic_areas":[55],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-4757","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","products_tags-vesicle-prep-pro","resource_type-publication","therapeutic_areas-cns"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/4757","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=4757"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=4757"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=4757"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=4757"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=4757"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=4757"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=4757"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=4757"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=4757"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}