{"id":17698,"date":"2025-07-08T12:44:48","date_gmt":"2025-07-08T12:44:48","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=17698"},"modified":"2025-07-08T12:44:48","modified_gmt":"2025-07-08T12:44:48","slug":"2025-permeability-selection-of-biologically-relevant-membranes-matches-the-stereochemistry-of-life-on-earth","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/2025-permeability-selection-of-biologically-relevant-membranes-matches-the-stereochemistry-of-life-on-earth\/","title":{"rendered":"2025 &#8211; Permeability selection of biologically relevant membranes matches the stereochemistry of life on Earth"},"content":{"rendered":"<p>Early in the evolution of life, a proto-metabolic network was encapsulated within a membrane compartment. The permeability characteristics of the membrane determined several key functions of this network by determining which compounds could enter the compartment and which compounds could not. One key feature of known life is the utilization of right-handed\u00a0<span class=\"small-caps\">d<\/span>-ribose and\u00a0<span class=\"small-caps\">d<\/span>-deoxyribose sugars and left-handed\u00a0<span class=\"small-caps\">l<\/span>-amino acid stereochemical isomers (enantiomers); however, it is not clear why life adopted this specific chirality. Generally, archaea have\u00a0<span class=\"small-caps\">l<\/span>-phospholipid membrane chemistries and bacteria and eukaryotes have\u00a0<span class=\"small-caps\">d<\/span>-phospholipid membrane chemistries. We previously demonstrated that an\u00a0<span class=\"small-caps\">l<\/span>-archaeal and a\u00a0<span class=\"small-caps\">d<\/span>-intermediate membrane mimic, bearing a mixture of bacterial and archaeal lipid characteristics (a \u2018hybrid\u2019 membrane), displayed increased permeability for several key compounds compared to bacterial-like membranes. Here, we investigate if these membranes can drive stereochemical selection on pentose sugars, hexose sugars, and amino acids. Using permeability assays of homogenous unilamellar vesicles, we demonstrate that both membranes select for\u00a0<span class=\"small-caps\">d<\/span>-ribose and\u00a0<span class=\"small-caps\">d<\/span>-deoxyribose sugars while the hybrid membrane uniquely selects for a reduced alphabet of\u00a0<span class=\"small-caps\">l<\/span>-amino acids. This repertoire includes alanine, the plausible first\u00a0<span class=\"small-caps\">l<\/span>-amino acid utilized. We conclude such compartments could provide stereochemical compound selection matching those used by the core metabolism of life.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[129],"resource_type":[75],"application_areas":[53],"therapeutic_areas":[143],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-17698","resource_library","type-resource_library","status-publish","hentry","products_tags-vesicle-prep-pro","resource_type-publication","application_areas-assay-development-and-validation","therapeutic_areas-assay-development-and-validation"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/17698","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=17698"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=17698"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=17698"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=17698"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=17698"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=17698"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=17698"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=17698"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=17698"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}