{"id":16877,"date":"2025-02-11T14:40:56","date_gmt":"2025-02-11T14:40:56","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=16877"},"modified":"2025-02-11T14:40:56","modified_gmt":"2025-02-11T14:40:56","slug":"2025-lyso-preps-for-organellar-electrophysiology-a-new-tool-for-high-throughput-measurement-of-lysosomal-trpml1-channels-using-the-syncropatch-384-surfe2r-n1-and-surfe2r-96se","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/2025-lyso-preps-for-organellar-electrophysiology-a-new-tool-for-high-throughput-measurement-of-lysosomal-trpml1-channels-using-the-syncropatch-384-surfe2r-n1-and-surfe2r-96se\/","title":{"rendered":"2025 &#8211; LYSO-Preps for organellar electrophysiology: A new tool for high throughput measurement of lysosomal TRPML1 channels using the SyncroPatch 384,  SURFE2R N1 and SURFE2R 96SE"},"content":{"rendered":"<p>Lysosomes are essential for cellular homeostasis and their dysfunction is linked to a wide range of diseases. Given the immediate medical relevance, there is a current need for high throughput electrophysiology on lysosomes.\u00a0Oria Bioscience have pioneered a novel approach for lysosomal isolation resulting in large batches of ready-to-use \u201cLYSO-Preps\u201d of high purity. We have successfully characterized \u201cLYSO-Preps\u201d overexpressing TRPML1 channels through pharmacology of activators, inhibitors and intraluminal pH sensitivity using the SyncroPatch 384, the SURFE<sup>2<\/sup>R N1 and the SURFE<sup>2<\/sup>R 96SE.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[42,36,132],"resource_type":[75],"application_areas":[50,76,108],"therapeutic_areas":[143,403],"target_categories":[60],"target_families":[339],"targets":[251],"resource_keyword":[],"class_list":["post-16877","resource_library","type-resource_library","status-publish","hentry","products_tags-syncropatch-384","products_tags-surfe2r-n1","products_tags-surfe2r-96se","resource_type-publication","application_areas-ion-channels","application_areas-drug-discovery","application_areas-transporters","therapeutic_areas-assay-development-and-validation","therapeutic_areas-lysosomal-diseases","target_categories-transporters","target_families-trp-channels","targets-trpml1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/16877","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=16877"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=16877"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=16877"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=16877"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=16877"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=16877"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=16877"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=16877"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=16877"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}