{"id":14574,"date":"2024-06-24T09:56:30","date_gmt":"2024-06-24T09:56:30","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=14574"},"modified":"2024-10-17T10:39:32","modified_gmt":"2024-10-17T10:39:32","slug":"nav-kv-gabaa-glycine-the-impact-of-astrocytes-on-the-maturation-of-hipsc-derived-neurons","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/nav-kv-gabaa-glycine-the-impact-of-astrocytes-on-the-maturation-of-hipsc-derived-neurons\/","title":{"rendered":"NaV, KV, GABAA, glycine &#8211; &#8220;The impact of astrocytes on the maturation of hiPSC-derived neurons&#8221;"},"content":{"rendered":"<p>Stem cell-derived neurons have become important tools in neuroscience research and a number of hiPSC- derived neuronal types are currently available on the market. Culture conditions are critical for maturation of hiPSC-derived neurons and it was discovered early on that commonly used culture media, e.g. DMEM-basal, Neurobasal or serum, while promoting neuronal survival, could actually impair neurophysiological functions. In order to promote maturation of neurons, they can be co-cultured with astrocytes. In collaboration with the Fraunhofer Institute for Biomedical Engineering (IBMT) we explored co-culture of hiPSC-derived neurons (EBiSC-NEUR1) and astrocytes (ScienCell, #1800) by comparing the electrophysiological properties of the neurons using the SyncroPatch 384.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[42],"resource_type":[90],"application_areas":[53,77],"therapeutic_areas":[143],"target_categories":[61,337],"target_families":[332,333,357,359],"targets":[],"resource_keyword":[],"class_list":["post-14574","resource_library","type-resource_library","status-publish","hentry","products_tags-syncropatch-384","resource_type-application-note","application_areas-assay-development-and-validation","application_areas-cell-ipscs-profiling","therapeutic_areas-assay-development-and-validation","target_categories-voltage-gated-ion-channels","target_categories-ligand-gated-ion-channels","target_families-nav-channels","target_families-kv-channels","target_families-glycine-receptors","target_families-gabaa-receptors"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/14574","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=14574"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=14574"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=14574"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=14574"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=14574"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=14574"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=14574"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=14574"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=14574"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}