{"id":13561,"date":"2024-01-26T09:05:59","date_gmt":"2024-01-26T09:05:59","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13561"},"modified":"2024-02-07T08:48:32","modified_gmt":"2024-02-07T08:48:32","slug":"cardiomyocytes-monitoring-the-effect-of-triiodothyronine-t3-and-dexmethasone-dex-on-the-calcium-handling-property-of-hipsc-cardiomyocytes","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/cardiomyocytes-monitoring-the-effect-of-triiodothyronine-t3-and-dexmethasone-dex-on-the-calcium-handling-property-of-hipsc-cardiomyocytes\/","title":{"rendered":"Cardiomyocytes &#8211; Monitoring the effect of Triiodothyronine (T3) and Dexmethasone (Dex) on the calcium handling property of hiPSC-Cardiomyocytes"},"content":{"rendered":"<p>Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) provide new avenues for disease modelling, drug discovery and cell therapy. However, structural and functional immaturity of these cells, poses a great challenge. Therefore, there is a highly unmet need for hiPSC-CMs with a mature phenotype. Recently, it has been reported that triiodothyronine (T3) and dexamethasone (Dex) play significant roles in hiPSCCMs maturation, by promoting the structural T-tubule development, enhancing the electrophysiological maturation and improving calcium handling ability.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[34],"resource_type":[90],"application_areas":[53,77],"therapeutic_areas":[54,143],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-13561","resource_library","type-resource_library","status-publish","hentry","products_tags-cardioexcyte-96","resource_type-application-note","application_areas-assay-development-and-validation","application_areas-cell-ipscs-profiling","therapeutic_areas-cardiac-safety-cipa","therapeutic_areas-assay-development-and-validation"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/13561","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=13561"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=13561"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=13561"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=13561"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=13561"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=13561"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=13561"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=13561"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=13561"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}