{"id":13391,"date":"2023-06-16T11:16:48","date_gmt":"2023-06-16T11:16:48","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13391"},"modified":"2024-01-11T11:23:10","modified_gmt":"2024-01-11T11:23:10","slug":"2023-biological-fractionation-of-lithium-isotopes-by-cellular-na-h-exchangers-unravels-fundamental-transport-mechanisms","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/2023-biological-fractionation-of-lithium-isotopes-by-cellular-na-h-exchangers-unravels-fundamental-transport-mechanisms\/","title":{"rendered":"2023 &#8211; Biological fractionation of lithium isotopes by cellular Na+\/H+ exchangers unravels fundamental transport mechanisms"},"content":{"rendered":"<p>Lithium (Li) has a wide range of uses in science, medicine, and industry, but its isotopy is underexplored, except in nuclear science and in geoscience.\u00a0<sup>6<\/sup>Li and\u00a0<sup>7<\/sup>Li\u00a0isotopic ratio\u00a0exhibits the second largest variation on earth\u2019s surface and constitutes a widely used tool for reconstructing past oceans and climates. As large variations have been measured in mammalian organs, plants or marine species, and as\u00a0<sup>6<\/sup>Li elicits stronger effects than natural Li (\u223c95%\u00a0<sup>7<\/sup>Li), a central issue is the identification and quantification of biological influence of Li isotopes distribution. We show that membrane ion channels and Na<sup>+<\/sup>-Li<sup>+<\/sup>\/H<sup>+<\/sup>\u00a0exchangers (NHEs) fractionate Li isotopes. This systematic\u00a0<sup>6<\/sup>Li enrichment is driven by membrane potential for channels, and by\u00a0intracellular pH\u00a0for NHEs, where it displays cooperativity, a hallmark\u00a0of dimeric transport. Evidencing that transport proteins discriminate between\u00a0isotopes differing by one neutron opens new avenues for transport mechanisms, Li physiology, and paleoenvironments.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[40],"resource_type":[75],"application_areas":[53,108],"therapeutic_areas":[143],"target_categories":[60],"target_families":[343],"targets":[],"resource_keyword":[],"class_list":["post-13391","resource_library","type-resource_library","status-publish","hentry","products_tags-orbit-mini","resource_type-publication","application_areas-assay-development-and-validation","application_areas-transporters","therapeutic_areas-assay-development-and-validation","target_categories-transporters","target_families-exchanger"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/13391","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=13391"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=13391"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=13391"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=13391"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=13391"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=13391"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=13391"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=13391"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=13391"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}