{"id":13215,"date":"2023-12-19T14:46:05","date_gmt":"2023-12-19T14:46:05","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13215"},"modified":"2025-03-04T11:12:58","modified_gmt":"2025-03-04T11:12:58","slug":"cardiotox-cardio-oncology-chronic-cardiotoxicity-study-on-h9c2-cells-using-hesi-stem-cell-working-group-reference-compounds","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/cardiotox-cardio-oncology-chronic-cardiotoxicity-study-on-h9c2-cells-using-hesi-stem-cell-working-group-reference-compounds\/","title":{"rendered":"Cardiotox., cardio-oncology &#8211; &#8220;Chronic cardiotoxicity study on H9C2  cells using HESI stem cell working group reference compounds&#8221;"},"content":{"rendered":"<p>Long-term exposure to cancer-related therapeutics has been linked to alterations of cardiac function in patients. The Stem Cell Working Group as part of the Health and Environmental<br \/>\nScience Institute (HESI) currently endeavors to gain further insight into chronic cardiotoxicity. The objective of the HESI study is to optimize non-clinical safety assessment strategies<br \/>\nof chronic cardiotoxicity by testing prolonged exposure of compounds on different cell-based assay systems using human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs), by investigating e.g. contractility or contractile force<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[419],"resource_type":[90],"application_areas":[53,76,77],"therapeutic_areas":[54,57,143],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-13215","resource_library","type-resource_library","status-publish","hentry","products_tags-atlaz","resource_type-application-note","application_areas-assay-development-and-validation","application_areas-drug-discovery","application_areas-cell-ipscs-profiling","therapeutic_areas-cardiac-safety-cipa","therapeutic_areas-cancer","therapeutic_areas-assay-development-and-validation"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/13215","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=13215"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=13215"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=13215"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=13215"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=13215"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=13215"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=13215"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=13215"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=13215"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}