{"id":13157,"date":"2023-12-05T11:45:29","date_gmt":"2023-12-05T11:45:29","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13157"},"modified":"2023-12-05T11:45:29","modified_gmt":"2023-12-05T11:45:29","slug":"nav-kv-gabaa-stem-cell-derived-neurons-recorded-on-nanions-patchliner","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/nav-kv-gabaa-stem-cell-derived-neurons-recorded-on-nanions-patchliner\/","title":{"rendered":"NaV, KV, GABAA &#8211; &#8220;Stem cell derived neurons recorded on Nanion\u2019s Patchliner&#8221;"},"content":{"rendered":"<p>Stem cell\u2013derived neurons provide a novel and unique model for studying human drug targets in their physiologically relevant environment of terminally differentiated, postmitotic cells. It has been increasingly recognized that associated proteins modulate the physiology and pharmacology of neuronal proteins. Therefore, assays that investigate neuronal toxicity, drug effects, or basic cellular functions of neurons can mostly benefit from the development of human neurons derived from induced pluripotent stem cells (hiPSC-neurons). In 2011, Fujifilm Cellular Dynamics International (CDI) announced the commercial launch of human iCell\u00ae Neurons for use in neuroscience drug discovery, neurotoxicity screens, and other health research. This was the first commercially available iPSC-derived neuronal type available3. It was a mixture of GABAergic and glutamatergic post-mitotic neurons which rapidly regenerate post-thaw. Over the years, Fujifilm Cellular Dynamics International has developed a range of hiPSC-neurons with either healthy or diseased models. These can be used to study a number of different neurodegenerative diseases including Alzheimer\u2019s Disease, one of the leading causes on death in the United States5.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[90],"application_areas":[50,53,77],"therapeutic_areas":[143],"target_categories":[61],"target_families":[332,333,359],"targets":[],"resource_keyword":[],"class_list":["post-13157","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-application-note","application_areas-ion-channels","application_areas-assay-development-and-validation","application_areas-cell-ipscs-profiling","therapeutic_areas-assay-development-and-validation","target_categories-voltage-gated-ion-channels","target_families-nav-channels","target_families-kv-channels","target_families-gabaa-receptors"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/13157","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=13157"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=13157"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=13157"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=13157"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=13157"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=13157"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=13157"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=13157"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=13157"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}