{"id":13152,"date":"2023-12-05T11:38:06","date_gmt":"2023-12-05T11:38:06","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13152"},"modified":"2023-12-05T11:38:06","modified_gmt":"2023-12-05T11:38:06","slug":"kv7-2-7-3-cross-site-study-of-neuronal-kv7-2-7-3-heteromers-on-the-patchliner","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/zh-hans\/resource_library\/kv7-2-7-3-cross-site-study-of-neuronal-kv7-2-7-3-heteromers-on-the-patchliner\/","title":{"rendered":"Kv7.2-7.3- &#8220;Cross-site study of neuronal KV7.2\/7.3 heteromers on the Patchliner&#8221;"},"content":{"rendered":"<p>The K<sub>V<\/sub>7 channels are a family of voltage-gated potassium ion channels with five members (K<sub>V<\/sub>7.1 &#8211; 7.5) encoded by the KCNQ1-5 genes1. The channels exist as tetramers, with each subunit containing six transmembrane domains with cytoplasmic N- and C-termini. The long intracellular terminus is essential for tetramerization as well as interaction with critical regulators such as PIP2, calmodulin, protein kinase C and ankyrin G2. K<sub>V<\/sub>7-mediated currents are voltage activated, slowly activating and non-inactivating and are involved in repolarization of the cell membrane potential, thereby controlling cell excitability. K<sub>V<\/sub>7.1 channels are primarily expressed in cardiac cells whereas K<sub>V<\/sub>7.2, K<sub>V<\/sub>7.3 and K<sub>V<\/sub>7.5 are widely distributed in neuronal and primary sensory cells2. K<sub>V<\/sub>7.2\/7.3 heteromeric channels primarily underlie the neuronal M-current (IKM)which plays a crucial role in repolarizing neuronal membrane potential after a depolarizing input which limits repetitive firing and is, therefore, a key mechanism in spike frequency adaptation.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[90],"application_areas":[50,53],"therapeutic_areas":[55,143],"target_categories":[61],"target_families":[333],"targets":[295,455],"resource_keyword":[],"class_list":["post-13152","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-application-note","application_areas-ion-channels","application_areas-assay-development-and-validation","therapeutic_areas-cns","therapeutic_areas-assay-development-and-validation","target_categories-voltage-gated-ion-channels","target_families-kv-channels","targets-kv7-2","targets-kv7-3"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library\/13152","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=13152"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/products_tags?post=13152"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_type?post=13152"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/application_areas?post=13152"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/therapeutic_areas?post=13152"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_categories?post=13152"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/target_families?post=13152"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/targets?post=13152"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/resource_keyword?post=13152"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}