{"id":901,"date":"2022-08-30T09:10:43","date_gmt":"2022-08-30T09:10:43","guid":{"rendered":"http:\/\/ionchanneltargets.com\/?page_id=901"},"modified":"2026-02-03T14:13:00","modified_gmt":"2026-02-03T12:13:00","slug":"respiratory-diseases","status":"publish","type":"page","link":"https:\/\/nanion.com\/zh-hans\/science-hub\/therapeutic-areas\/respiratory-diseases\/","title":{"rendered":"Respiratory diseases"},"content":{"rendered":"<div id=\"pl-901\" class=\"panel-layout\"><div id=\"pg-901-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-901-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-901-0-0\" class=\"panel-grid-cell\"><div id=\"panel-901-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-901\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Respiratory diseases<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tBreathing ion channels. <\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-901-1\"><div id=\"pgc-901-1-0\" class=\"panel-grid-cell\"><div id=\"panel-901-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-901\"><style>\n    \/*.read-more-section .image-wrapper #box-img-337565269{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-337565269 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-540650495\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-337565269\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Respiratory_840x1040.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Respiratory_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2>Ion channels and transporters involved in <strong>respiratory diseases<\/strong><\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Respiratory disease is a growing medical issue due to lifestyle, environmental and genetic factors, with research ongoing to find treatments for asthma, cough, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and cystic fibrosis (CF). Ion channels are potential therapeutic targets for several respiratory diseases, which include purinergic receptors to treat chronic cough and the CFTR channel expressed in lung airway epithelium for CF. The role of ion channels and transporters in viral respiratory disease has also been highlighted by the recent COVID-19 pandemic, where they facilitate viral entry and replication, whilst also playing a role in the immune response and inflammation.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-540650495 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-540650495 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-540650495\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-540650495\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-901-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-901-2-1\" class=\"panel-grid-cell\"><div id=\"panel-901-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>From CFTR<\/strong> to viroporins<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-901-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-3\"><div id=\"pgc-901-3-0\" class=\"panel-grid-cell\"><div id=\"panel-901-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-901\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channels in chronic cough and CFTR<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-901-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-3-1\"><div id=\"panel-901-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Chronic cough is one of the major reasons for GP visits in the US. In recent years, P2X<sub>3<\/sub> ionotropic receptors have been implicated in respiratory hyperactivity seen in asthma and chronic cough. Several P2X<sub>3<\/sub> inhibitors have reached clinical trials for chronic and refractory cough, although adverse effects on taste sensation have been reported and it is hoped that more selective drugs will reduce these side effects. In addition, some voltage-gated Na<sup>+<\/sup> channels such as Na<sub>V<\/sub>1.3 and Na<sub>V<\/sub>1.7&nbsp; are attractive targets for cough therapeutics due to their presence on sensory and vagal nerves.<\/p>\n<p>Cystic Fibrosis is a rare fatal hereditary lung disease. Mutations in the cystic fibrosis conductance regulator (CFTR) in airway epithelia affect electrolyte transport, mucus obstruction, neutrophilic inflammation and bacterial infection, leading to chronic lung disease and premature mortality. Another potential target for the treatment of CF is TMEM16A, a calcium-activated chloride channel expressed in airway surface epithelium as well as in submucosal glands and goblet cells. Recently, a positive modulator of TMEM16A was shown to enhance anion and fluid secretion from cystic fibrosis patients. This target mechanism presents a novel approach to treat a wide range of cystic fibrosis patients and other respiratory disorders.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-901-3-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"5\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-901\">\n<div class=\"sow-image-container\">\n\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro.png\" width=\"788\" height=\"510\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro.png 788w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro-300x194.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro-768x497.png 768w\" sizes=\"(max-width: 788px) 100vw, 788px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20788%20510%22%3E%3C%2Fsvg%3E\" width=\"788\" height=\"510\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20788%20510%22%3E%3C%2Fsvg%3E 788w\" sizes=\"(max-width: 788px) 100vw, 788px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro.png 788w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro-300x194.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro-768x497.png 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/CFTR-on-Syncro.png\">\n\t<\/div>\n\n<\/div><\/div><div id=\"panel-901-3-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Online data analysis of CFTR expressing CHO cells as recorded on SyncroPatch 384, using one NPC-384 (multi-hole, 8 holes per well) patch clamp chip. Three hundred and eighty-four small color-coded pictures as seen in the upper left part display 384 recordings. One highlighted experiment is displayed at the bottom, 16 selected experiments are displayed on the right. Graphs show current amplitudes of CFTR activated by external forskolin (10 \u00b5M; white region), potentiation by increasing concentrations of genistein (1, 10, 100 \u00b5M; blue regions), and full block by 300 \u00b5M glibenclamide (grey region).<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-4\"><div id=\"pgc-901-4-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-901-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-4-1\"><div id=\"panel-901-4-1-0\" class=\"so-panel widget widget_filedownload-theme-widget panel-first-child panel-last-child\" data-index=\"7\"><div class=\"so-widget-filedownload-theme-widget so-widget-filedownload-theme-widget-default-d75171398898-901\">    <div class=\"filedownload-widget\">\n        <div class=\"download-list\"> \n                            <div class=\"download-item\">\n                    <a href=\"\/wp-content\/uploads\/2023\/02\/Nanion_APP_Note_384PE_CFTR_06011.pdf?1677678866\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        <span class=\"title\">Download Application Note<\/span>\n                        <span class=\"desc\"><\/span>\n                    <\/a>\n                <\/div>\n                        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-5\"><div id=\"pgc-901-5-0\" class=\"panel-grid-cell\"><div id=\"panel-901-5-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child\" data-index=\"8\"><div class=\"panel-widget-style panel-widget-style-for-901-5-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-901\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\"><\/h4><\/div><\/div><\/div><\/div><div id=\"panel-901-5-0-1\" class=\"so-panel widget widget_characters-max-header-widget panel-last-child\" data-index=\"9\"><div class=\"panel-widget-style panel-widget-style-for-901-5-0-1\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-901\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channels in respiratory viral infections and immunity<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-901-5-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-5-1\"><div id=\"panel-901-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The recent COVID-19 pandemic in 2020 - 2022 has highlighted the importance of ion channels in viral entry into human cells, viral replication and anti-viral immunity. For example, viroporins are small integral membrane ion channels essential for the life cycle of a diverse range of RNA and DNA viruses. Viroporins are potential drug targets for the block of viral replication and the spread of infection, with examples including envelope E protein cation channel in SARS CoV-2, M2 proton channel in influenza virus, polio virus 2B Ca<sup>2+<\/sup> channel, and the hepatitis virus p7 proton channel. On the other hand, two pore channels (TPC) have been shown to play a key role in Ebola virus infection. In endosomal membranes they are responsible for entry of Ebola virus and may provide a therapeutic target as an antiviral for Ebola virus and other filoviruses.<\/p>\n<p>Ca<sup>2+<\/sup>-release activated calcium (CRAC) channels are required for the differentiation and function of T lymphocytes, thus providing immunity to infection, as well as mediating inflammation and preventing autoimmunity. Therefore, CRAC inhibitors could be novel therapeutics for autoimmune or inflammatory conditions. For example, the CRAC channel blocker, CM4620-IE, from <a href=\"https:\/\/calcimedica.com\/2020\/04\/09\/p3y3hlbl964kepsv59s14rbuckhkc8-mhy4x\/\" target=\"_blank\" rel=\"noopener\">CalciMedica<\/a> has recently entered Phase II clinical trials to prevent a cytokine storm in COVID-19 patients. Additionally, volume-regulated anion channels (VRAC) have been shown to play a crucial role in anti-viral immunity via cGAMP transmission between cells mediated by these ion channels.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-901-5-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"11\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-901\">\n<div class=\"sow-image-container\">\n\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours.jpg\" width=\"1596\" height=\"1457\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours.jpg 1596w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-300x274.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-1024x935.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-768x701.jpg 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-1536x1402.jpg 1536w\" sizes=\"(max-width: 1596px) 100vw, 1596px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201596%201457%22%3E%3C%2Fsvg%3E\" width=\"1596\" height=\"1457\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201596%201457%22%3E%3C%2Fsvg%3E 1596w\" sizes=\"(max-width: 1596px) 100vw, 1596px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours.jpg 1596w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-300x274.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-1024x935.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-768x701.jpg 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours-1536x1402.jpg 1536w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Fig_1_WT_KO_PL_Hypotonic_DIDS_Alternative_newcolours.jpg\">\n\t<\/div>\n\n<\/div><\/div><div id=\"panel-901-5-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"12\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Recordings of LRRC8 from wild type (WT) and LRRC8A<sup>-\/-<\/sup> knockout (KO) HaCaT keratinocytes measured on the Patchliner. Shown are current responses to a voltage ramp protocol in isotonic and hypotonic solution and the corresponding timecourse of the experiment from the two groups of cells.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-6\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-6\"><div id=\"pgc-901-6-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-901-6-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-6-1\"><div id=\"panel-901-6-1-0\" class=\"so-panel widget widget_filedownload-theme-widget panel-first-child panel-last-child\" data-index=\"13\"><div class=\"so-widget-filedownload-theme-widget so-widget-filedownload-theme-widget-default-d75171398898-901\">    <div class=\"filedownload-widget\">\n        <div class=\"download-list\"> \n                            <div class=\"download-item\">\n                    <a href=\"\/wp-content\/uploads\/2023\/02\/Nanion_APP_Note_384_PL_VRAC_BRAIN_Keratinocytes_07005_000.pdf?1677679040\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        <span class=\"title\">Download Application Note<\/span>\n                        <span class=\"desc\"><\/span>\n                    <\/a>\n                <\/div>\n                        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-7\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-7\"><div id=\"pgc-901-7-0\" class=\"panel-grid-cell\"><div id=\"panel-901-7-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"14\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-901\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Transporters in respiratory viral transmission<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-901-7-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-7-1\"><div id=\"panel-901-7-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"15\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>In addition to ion channels, some transporters have also been implicated in virus recognition and infection. The sodium-dependent neutral amino acid transporter B<sup>0<\/sup>AT1 is a protein that mediates epithelial resorption of neutral amino acids across the apical membrane in the kidney and intestine. &nbsp;Recently it has been shown that the angiotensin-converting enzyme 2 (ACE2) and B<sup>0<\/sup>AT1 protein form a complex for recognition of the SARS-CoV-2 virus, thereby playing a role in coronavirus recognition and infection.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-901-7-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"16\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-901\">\n<div class=\"sow-image-container\">\n\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3.jpg\" width=\"995\" height=\"704\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3.jpg 995w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3-300x212.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3-768x543.jpg 768w\" sizes=\"(max-width: 995px) 100vw, 995px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20995%20704%22%3E%3C%2Fsvg%3E\" width=\"995\" height=\"704\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20995%20704%22%3E%3C%2Fsvg%3E 995w\" sizes=\"(max-width: 995px) 100vw, 995px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3.jpg 995w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3-300x212.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3-768x543.jpg 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/B0AT_SURFE2R96SE-3.jpg\">\n\t<\/div>\n\n<\/div><\/div><div id=\"panel-901-7-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"17\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>B<sup>0<\/sup>AT1 expressed in&nbsp; CHO cell membranes was activated on the SURFE<sup>2<\/sup>R 96. (<strong>A<\/strong>) Activation buffer containing leucine was used to induce electrical currents. The presence of both leucine and Na<sup>+<\/sup> were required to activate B<sup>0<\/sup>AT1. (<b>B<\/b>) Testing of stereoselectivity of B<sup>0<\/sup>AT1 membranes demonstrated a preference for&nbsp;<span data-style=\"small-caps\">l<\/span>-leucine. (<strong>C<\/strong>) When B<sup>0<\/sup>AT1 was not expressed, no currents were recorded. (<strong>D<\/strong>) Dependence of leucine transport on decreasing Na<sup>+<\/sup> concentrations.<\/p>\n<p><a href=\"https:\/\/journals.sagepub.com\/doi\/full\/10.1177\/24725552211011180\" target=\"_blank\" rel=\"noopener\">Gerbeth-Kreul C., et al., SLAS Discovery. (2021)<\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-8\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-901-8\"><div id=\"pgc-901-8-0\" class=\"panel-grid-cell\"><div id=\"panel-901-8-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"18\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-901\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channels and transporters in respiratory diseases<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-901-8-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-8-1\"><div id=\"panel-901-8-1-0\" class=\"so-panel widget widget_specifications-theme-widget panel-first-child panel-last-child\" data-index=\"19\"><div class=\"so-widget-specifications-theme-widget so-widget-specifications-theme-widget-default-d75171398898-901\">    <div class=\"specifications-list\">\n                    <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Chronic cough<\/div>\n                <div class=\"col-6 px-0 value\">P2X<sub>3<\/sub>, Na<sub>V<\/sub>1.3, Na<sub>V<\/sub>1.7<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Cystic Fibrosis<\/div>\n                <div class=\"col-6 px-0 value\">CFTR, TMEM16A<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Autoimmune\/ inflammatory conditions<\/div>\n                <div class=\"col-6 px-0 value\">CRAC<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Viral entry, replication and immunity<\/div>\n                <div class=\"col-6 px-0 value\">Viroporins, TPC, VRAC, B<sup>0<\/sup>AT1<\/div>\n            <\/div>\n                <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-9\" class=\"panel-grid panel-no-style\"><div id=\"pgc-901-9-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-901-9-1\" class=\"panel-grid-cell\"><div id=\"panel-901-9-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"20\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Assay platforms <\/strong>for<\/h2>\n<h2>respiratory disease research<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-901-10\" class=\"panel-grid panel-no-style\"><div id=\"pgc-901-10-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-901-10-0\"><div id=\"panel-901-10-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"21\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-901-10-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-901\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tAutomated patch clamp,<br> transporter assays and bilayers\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-901-10-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-901-10-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"22\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Automated patch clamp platforms are well suited to study ion channels involved in respiratory diseases. Purinergic P2X receptors can be recorded using the <a href=\"\/products\/port-a-patch\/\">Port-a-Patch<\/a>, <a href=\"\/products\/patchliner\/\">Patchliner<\/a> and <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a>, taking advantage of the fast external solution exchange. Block of P2X<sub>3<\/sub> and P2X<sub>2\/3<\/sub> receptors by gefapixant has been shown on the Port-a-Patch in a paper published in the <a href=\"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full\/10.1111\/bph.14677\" target=\"_blank\" rel=\"noopener\">British Journal of Pharmacology in 2019<\/a>. The Patchliner is routinely used in cystic fibrosis research to record the CFTR and F508del-CFTR using fluoride-free internal solution (<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5383655\/\" target=\"_blank\" rel=\"noopener\">Billet, A., et al., Front. Pharmacol. (2017)<\/a>; <a href=\"https:\/\/erj.ersjournals.com\/content\/59\/2\/2100671.long\" target=\"_blank\" rel=\"noopener\">Becq F., et al., Eur. Resp. J. (2021)<\/a>. The use of internal exchange on the Patchliner and internal perfusion on the SyncroPatch 384 can be used to activate currents with Ca<sup>2+<\/sup> or cAMP on the inside of the cell after whole-cell access has been achieved.<\/p>\n<p>Transporters involved in viral recognition and immunity can be recorded on the <a href=\"\/products\/surfe2r-n1\/\">SURFE<sup>2<\/sup>R N1<\/a> and at higher throughput on the <a href=\"\/products\/surfer-96se\/\">SURFE<sup>2<\/sup>R 96<\/a> instruments and recombinant viral proteins such as viroporins can be reconstituted into bilayers and recorded on the <a href=\"\/products\/orbit-mini\/\">Orbit mini<\/a> and<a href=\"\/products\/orbit-16tc\/\"> Orbit 16 TC<\/a>. The <a href=\"\/products\/vesicle-prep-pro\/\" target=\"_blank\" rel=\"noopener\">Vesicle Prep Pro<\/a> can be used to make giant unilamellar vesicles for expression of viral proteins and transporters for further studies.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-901-10-1-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"23\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-901\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/target-database\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\">\n\t\t<span>\n\t\t\t\n\t\t\tTarget database\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-901-10-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-901-11\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-901-11\"><div id=\"pgc-901-11-0\" class=\"panel-grid-cell\"><div id=\"panel-901-11-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"24\"><div id=\"pl-w6981e64c1a1ca\" class=\"panel-layout\"><div id=\"pg-w6981e64c1a1ca-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e64c1a1ca-0\"><div id=\"pgc-w6981e64c1a1ca-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w6981e64c1a1ca-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w6981e64c1a1ca-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6981e64c1a1ca-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6981e64c1a1ca-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6981e64c1a1ca-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e64c1a1ca-1\"><div id=\"pgc-w6981e64c1a1ca-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e64c1a1ca-1-0\"><div id=\"panel-w6981e64c1a1ca-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6981e64c1a1ca-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Cecilia George (Global Head of SURFE<sup>2<\/sup>R Sales \/ Senior Scientist ). Cecilia is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e64c1a1ca-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e64c1a1ca-1-1\"><div id=\"panel-w6981e64c1a1ca-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6981e64c1a1ca-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:cecilia.george@nanion.de\">cecilia.george@nanion.de<\/a><\/strong><br>\nor connect via <strong><a href=\"https:\/\/www.linkedin.com\/in\/cecilia-george-75102ba\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e64c1a1ca-1-2\" class=\"panel-grid-cell\"><div id=\"panel-w6981e64c1a1ca-1-2-0\" class=\"so-panel widget widget_image-out-container-theme-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-image-out-container-theme-widget so-widget-image-out-container-theme-widget-default-d75171398898\">    <div class=\"img-out-container-warp\" style=\"max-width:420px;position:absolute;transform: translateX(65px); float:right; right:0; z-index: 10;\">\n        <style>.lazy-loader-background-element-1.lazyloaded{ background-image: url('https:\/\/nanion.com\/wp-content\/uploads\/2022\/10\/Dotted-grid-2-1.svg') !important; }<\/style><noscript><style>.lazy-loader-background-element-1.lazyload{ background-image: url('https:\/\/nanion.com\/wp-content\/uploads\/2022\/10\/Dotted-grid-2-1.svg') !important; }<\/style><\/noscript><div class=\"dotted-grid bottom-left mobile-disable-dotted-grid-aimation  lazyload lazy-loader-background-element-1 \" data-translatemarky=\"100\" data-translatemarkx=\"-100\" data-duration=\"180%\" data-mobilemargin=\"no\" style=\"width:340px;height:450px; max-width:100%;\"><\/div>        <div class=\"img-out-container\">\n            <noscript><img decoding=\"async\" width=\"840\" height=\"1040\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040.jpg\" class=\"attachment-full size-full\" alt srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040.jpg 840w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-242x300.jpg 242w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-827x1024.jpg 827w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-768x951.jpg 768w\" sizes=\"(max-width: 840px) 100vw, 840px\"><\/noscript><img decoding=\"async\" width=\"840\" height=\"1040\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20840%201040%22%3E%3C%2Fsvg%3E\" class=\"attachment-full size-full lazyload\" alt srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20840%201040%22%3E%3C%2Fsvg%3E 840w\" sizes=\"(max-width: 840px) 100vw, 840px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040.jpg 840w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-242x300.jpg 242w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-827x1024.jpg 827w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040-768x951.jpg 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Cecilia_840x1040.jpg\">        <\/div>\n                            <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-901-12\" class=\"panel-grid panel-no-style\"><div id=\"pgc-901-12-0\" class=\"panel-grid-cell\"><div class=\"no-padding-right full-width-right panel-cell-style panel-cell-style-for-901-12-0\"><div id=\"panel-901-12-0-0\" class=\"so-panel widget widget_news-slider-widget panel-first-child panel-last-child\" data-index=\"25\"><div class=\"so-widget-news-slider-widget so-widget-news-slider-widget-default-d75171398898-901\"><style>\n    .news-slider{\n        background-color: #f2f2f2;\n    }\n    .img-news-container-warp{\n        background-color: #f2f2f2;\n    }\n<\/style>\n<div class=\"img-news-container-warp\">\n    <div class=\"dotted-grid-news top-left\" data-translatemarky=\"-200\" data-translatemarkx=\"-200\" data-duration=\"180%\" style=\"transform: matrix(1, 0, 0, 1, 0, 0);\"><\/div>\n    <div class=\"news-slider\">\n                    <div class=\"see-all \">\n                <a href=\"https:\/\/nanion.com\/news\/\">See all news<\/a>\n            <\/div>\n                <div class=\"title-box\">\n            <h2>Nanion News<\/h2>\n            <p><\/p>\n        <\/div>\n                <div id=\"owl_carousel_848973363\" class=\"owl-carouselCard owl-theme\">\n                            <div class=\"item\" style=\"width:390px\">\n                                        <div class=\"row no-margin\">\n                        <div class=\"col-12 news-thumbnail\">\n                                                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/new-ways-to-activate-tmem175\/\">\n                                    <noscript><img decoding=\"async\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026-Publication-highlight_-New-ways-to-activate-TMEM175.png\"><\/noscript><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026-Publication-highlight_-New-ways-to-activate-TMEM175.png\" class=\" lazyload\">\n                                <\/a>\n                                                    <\/div>\n                        <div class=\"col-12 new-text\">\n                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/new-ways-to-activate-tmem175\/\">\n                                <p class=\"post-date\">08.10.2026<\/p>\n                                <h4>New ways to activate TMEM175<\/h4>\n                                <p><\/p>\n                                <div class=\"arrow-link\">Read more<\/div>\n                            <\/a>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                            <div class=\"item\" style=\"width:390px\">\n                                        <div class=\"row no-margin\">\n                        <div class=\"col-12 news-thumbnail\">\n                                                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-series-beyond-the-plasma-membrane\/\">\n                                    <noscript><img decoding=\"async\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png\"><\/noscript><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png\" class=\" lazyload\">\n                                <\/a>\n                                                    <\/div>\n                        <div class=\"col-12 new-text\">\n                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-series-beyond-the-plasma-membrane\/\">\n                                <p class=\"post-date\">07.10.2026<\/p>\n                                <h4>Webinar series: Beyond the Plasma Membrane<\/h4>\n                                <p>Webinars in the series will take place between 2026 and 2027<\/p>\n                                <div class=\"arrow-link\">Read more<\/div>\n                            <\/a>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                            <div class=\"item\" style=\"width:390px\">\n                                        <div class=\"row no-margin\">\n                        <div class=\"col-12 news-thumbnail\">\n                                                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-investigating-sarcoplasmic-reticulum-ca2-atpase-on-ssme\/\">\n                                    <noscript><img decoding=\"async\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-Tadini-scaled.png\"><\/noscript><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-Tadini-scaled.png\" class=\" lazyload\">\n                                <\/a>\n                                                    <\/div>\n                        <div class=\"col-12 new-text\">\n                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-investigating-sarcoplasmic-reticulum-ca2-atpase-on-ssme\/\">\n                                <p class=\"post-date\">06.10.2026<\/p>\n                                <h4>Webinar: Investigating sarcoplasmic reticulum Ca<sup>2+\n                                <p>Date: November 18, 2026\nTime: 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n                                <div class=\"arrow-link\">Read more<\/div>\n                            <\/sup><\/h4><\/a>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                            <div class=\"item\" style=\"width:390px\">\n                                        <div class=\"row no-margin\">\n                        <div class=\"col-12 news-thumbnail\">\n                                                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-exploring-cftr-function-and-pharmacology\/\">\n                                    <noscript><img decoding=\"async\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png\"><\/noscript><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png\" class=\" lazyload\">\n                                <\/a>\n                                                    <\/div>\n                        <div class=\"col-12 new-text\">\n                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-exploring-cftr-function-and-pharmacology\/\">\n                                <p class=\"post-date\">01.10.2026<\/p>\n                                <h4>Webinar: Exploring CFTR function and pharmacology<\/h4>\n                                <p>Date: November 5, 2026\nTime: 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n                                <div class=\"arrow-link\">Read more<\/div>\n                            <\/a>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                    <\/div>\n                <div class=\"see-all mobile \">\n            <a href=\"https:\/\/nanion.com\/news\/\">See all news<\/a>\n        <\/div>\n                <a class=\"rtl-false\">link<\/a>\n        <a class=\"rtl-true\">link<\/a>\n    <\/div>\n<\/div>\n\n<script>\n    jQuery(window).bind('load',function () {\n        var owl = jQuery('#owl_carousel_848973363');\n        var owlConfig = {\n            rtl: false,\n            items: 3,\n            loop: true,\n            \/\/navigation: false,\n            dots: true,\n            margin: 30,\n            autoplay: true,\n            autoplayTimeout:4500,\n            autoplaySpeed: 1500,\n            navSpeed: 1500,\n            autoplayHoverPause:true,\n            startPosition:0,\n            autoWidth:true,\n            responsiveClass: true,\n            responsive: {\n                0: {\n                    items:1,\n                    autoplay: false,\n                    autoWidth:false,\n                    stagePadding: 40,\n                },\n                600: {\n                    items:2,\n                    autoplay: false,\n                    autoWidth:false,\n                    stagePadding: 40,\n                },\n                767: {\n                    items:2,\n                    autoplay: false,\n                    autoWidth:false,\n                    stagePadding: 40,\n                },\n                991.5: {\n                    items:3,\n                    autoplay: true,\n                    stagePadding: 0,\n                }\n            }\n\n        }\n\n        setTimeout(function () {\n            owl.owlCarousel(owlConfig);\n            setNewsSliderWidth(owl);\n            var controller = new ScrollMagic.Controller();\n            jQuery(\".img-news-container-warp\").each(function() {\n                var tl = new TimelineMax();\n                \/\/console.log(tl);\n                var dotted_grid = jQuery(this).find(\".dotted-grid-news\");\n                var translate_mark_y = jQuery(this).find(\".dotted-grid-news\").attr('data-translatemarky');\n                var translate_mark_x = jQuery(this).find(\".dotted-grid-news\").attr('data-translatemarkx');\n                var duration = jQuery(this).find(\".dotted-grid-news\").attr('data-duration');\n                tl.to(dotted_grid, 1, { y: translate_mark_y, x: translate_mark_x, ease: Linear.easeNone });\n\n                var scene = new ScrollMagic.Scene({\n                    triggerElement: this,\n                    triggerHook: 0.8,\n                    duration: duration\n                }).setTween(tl).addTo(controller);\n            });\n        }, 1000);\n\n        let doit;\n        jQuery(window).resize(function(){\n            clearTimeout(doit);\n            doit = setTimeout(function(){\n                setNewsSliderWidth(owl);\n            },300);\n        })\n\n        jQuery('.rtl-false').on('click',function(){\n            owlConfig.rtl = false;\n            owl.owlCarousel('destroy');\n\n            owl.trigger('destroy.owl.carousel').removeClass('owl-carousel owl-loaded owl-rtl owl-responsive-1000');\n            owl.find('.owl-stage-outer').children().unwrap();\n            owl.owlCarousel(owlConfig);\n            setNewsSliderWidth(owl);\n        })\n\n        jQuery('.rtl-true').on('click',function(){\n            owlConfig.rtl = true;\n            owl.owlCarousel('destroy');\n\n            owl.trigger('destroy.owl.carousel').removeClass('owl-carousel owl-loaded owl-rtl owl-responsive-1000');\n            owl.find('.owl-stage-outer').children().unwrap();\n            owl.owlCarousel(owlConfig);\n            setNewsSliderWidth(owl);\n        });\n\n        function setNewsSliderWidth(owl){\n            if(jQuery(document).width() <= 992){\n                \/\/let owlItem = '265';\n\n                owl.find('.owl-stage-outer').css('margin-left','-40px');\n                jQuery('.news-slider .title-box').css({'width':'100%','position':'relative'});\n            }else{\n                \/\/let owlItem = '265';\n                let owlItem = owl.find('.owl-item').width() \/ 2,halfOwlItem = 0;\n                halfOwlItem = owlItem\/3;\n                owlItem = owlItem + halfOwlItem;\n\n                let plusMargin = 0;\n                if(jQuery(document).width() > 800 && jQuery(document).width() < 1200){\n                    plusMargin = 80;\n                }else{\n                    plusMargin = 50;\n                }\n                \n                owl.find('.owl-stage-outer').css('margin-left',(owlItem+plusMargin)+'px');\n                jQuery('.news-slider .title-box').css({'width': (owlItem+plusMargin-15)+'px','position':''});``\n            }\n            if(owlConfig.rtl === true){\n                owl.find('.owl-stage-outer').addClass('rtl-s');\n                jQuery(owl).closest('.news-slider').find('a.rtl-false').show();\n                jQuery(owl).closest('.news-slider').find('a.rtl-true').hide();\n            }else{\n                owl.find('.owl-stage-outer').removeClass('rtl-s');\n                jQuery(owl).closest('.news-slider').find('a.rtl-false').hide();\n                jQuery(owl).closest('.news-slider').find('a.rtl-true').hide();\n            }\n\n            jQuery('.news-slider').css('visibility','visible');\n        }\n    });\n<\/script><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Respiratory diseases Breathing ion channels. Ion channe [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":98,"menu_order":34,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-901","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/901","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=901"}],"version-history":[{"count":141,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/901\/revisions"}],"predecessor-version":[{"id":18907,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/901\/revisions\/18907"}],"up":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/98"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=901"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}