{"id":898,"date":"2022-08-30T09:09:18","date_gmt":"2022-08-30T09:09:18","guid":{"rendered":"http:\/\/ionchanneltargets.com\/?page_id=898"},"modified":"2025-10-23T06:37:28","modified_gmt":"2025-10-23T04:37:28","slug":"immune-diseases","status":"publish","type":"page","link":"https:\/\/nanion.com\/zh-hans\/science-hub\/therapeutic-areas\/immune-diseases\/","title":{"rendered":"Immune diseases"},"content":{"rendered":"<div id=\"pl-898\" class=\"panel-layout\"><div id=\"pg-898-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-898-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-898-0-0\" class=\"panel-grid-cell\"><div id=\"panel-898-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-898\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Immune diseases<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tFinding cures for cancer and \nauto-immune diseases.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-898-1\"><div id=\"pgc-898-1-0\" class=\"panel-grid-cell\"><div id=\"panel-898-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-898\"><style>\n    \/*.read-more-section .image-wrapper #box-img-567530589{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-567530589 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-293796086\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-567530589\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Immuno_840x1040.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Immuno_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2>The double-edged sword: the <strong>power of the immune system <\/strong><\/h2>\n<h2><\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>The immune system responds to foreign invaders and pathological changes in cells and tissues. B cells produce antibodies, T cells and microglia release inflammatory mediators and macrophages remove debris. These processes can be leveraged to treat diseases, such as vaccinations to elicit antibodies to fight viral infections, antibodies to fight Alzheimer\u2019s disease, modulating microglia to reduce neuro-inflammation, and immune-oncology that uses the immune system to recognize and remove tumors. The immune system can also target healthy cells and proteins to cause auto-immune diseases such as type 1 diabetes, rheumatoid arthritis, Myasthenia Gravis, and Multiple Sclerosis.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-293796086 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-293796086 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-293796086\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-293796086\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-898-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-898-2-1\" class=\"panel-grid-cell\"><div id=\"panel-898-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Ion channels in immune response<\/h2>\n<h2>and <strong>auto-immune disease<\/strong><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-898-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-898-3\"><div id=\"pgc-898-3-0\" class=\"panel-grid-cell\"><div id=\"panel-898-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-898-3-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-898\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Function of ion channels in immunity<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-3-1\"><div id=\"panel-898-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The complexity of the human immune system is reflected in the multiple cellular regulation mechanisms it uses.&nbsp; The activity and function of immune cells are regulated by various ion channels, making them attractive targets for inflammatory and auto-immune disease drug development. Academic and industry groups have developed antibodies, peptide toxins, and small molecule modulators for many of these immune cell ion channels. A &nbsp;derivative of a sea anemone toxin (ShK-186, Dalazatide) successfully reduced plaque psoriasis symptoms in a clinical trial, validating this drug discovery approach to treat inflammatory auto-immune disease. There is great interest in using a similar approach to regulate the activity of microglia in the brain to treat neuro-inflammatory and neurodegenerative diseases.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-898-3-1-1\" class=\"so-panel widget widget_sow-image panel-last-child\" data-index=\"5\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-898\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720.jpg\" width=\"1200\" height=\"720\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720.jpg 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-300x180.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-1024x614.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-768x461.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E\" width=\"1200\" height=\"720\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720.jpg 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-300x180.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-1024x614.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720-768x461.jpg 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels_immuno_1200x720.jpg\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-898-4\"><div id=\"pgc-898-4-0\" class=\"panel-grid-cell\"><div id=\"panel-898-4-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"6\"><div class=\"panel-widget-style panel-widget-style-for-898-4-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-898\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Auto-immune diseases<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-4-1\"><div id=\"panel-898-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Ion channels are also associated with several auto-immune diseases. Here, the immune system mistakenly recognizes normal human proteins as foreign, leading to T-cells attacking and destroying ion channels and ionotropic receptors. This process inflicts damage to tissues where these targets are expressed in, leading to metabolic and neurological diseases. Table below summarizes some of these diseases with respective ion channels proposed to be therapeutic targets for their treatment.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-898-5\"><div id=\"pgc-898-5-0\" class=\"panel-grid-cell\"><div id=\"panel-898-5-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"8\"><div class=\"panel-widget-style panel-widget-style-for-898-5-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-898\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Rheumatoid arthritis<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-5-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-5-1\"><div id=\"panel-898-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"9\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>A number of ion channels have been implicated in rheumatoid arthritis, a chronic autoimmune disease which manifests as inflammation within the synovial joints. It has been proposed that the ligand-gated ion channel, ASIC1a, plays a crucial role in the pathogenesis of rheumatoid arthritis. promoting inflammation, synovial hyperplasia, and destruction of bone which lead to the progression of the disease. The voltage-gated ion channels, K<sub>V<\/sub>1.3 and K<sub>Ca<\/sub>1.1 have also been proposed to play a role in rheumatoid arthritis by regulating fibroblast-like synoviocytes and T memory cells and a combined therapy of K<sub>V<\/sub>1.3 and K<sub>Ca<\/sub>1.1 blockers may prove to be a more effective treatment for the disease than one treatment type alone to slow progression of the disease.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-898-5-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"10\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-898\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"https:\/\/jpet.aspetjournals.org\/content\/early\/2018\/02\/16\/jpet.117.245118.long\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP.png\" width=\"1124\" height=\"512\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP.png 1124w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-300x137.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-1024x466.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-768x350.png 768w\" sizes=\"(max-width: 1124px) 100vw, 1124px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201124%20512%22%3E%3C%2Fsvg%3E\" width=\"1124\" height=\"512\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201124%20512%22%3E%3C%2Fsvg%3E 1124w\" sizes=\"(max-width: 1124px) 100vw, 1124px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP.png 1124w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-300x137.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-1024x466.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP-768x350.png 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/KCa11_arthritis_Tanner-et-al_2018_PaP.png\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><div id=\"panel-898-5-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"11\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Figure representing the scorpion venom peptide, iberiotoxin (IbTX) block of K<sub>Ca<\/sub>1.1 in fibroblast-like synoviocytes (FLS) with concentration response curves recoded using the <a href=\"\/products\/port-a-patch\/\">Port-a-Patch<\/a>.<\/p>\n<p><strong><a href=\"https:\/\/jpet.aspetjournals.org\/content\/early\/2018\/02\/16\/jpet.117.245118.long\" target=\"_blank\" rel=\"noopener\">Tanner M.R., et al. J. Pharmacol. &amp; Exp. Therap. (2018)<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-6\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-898-6\"><div id=\"pgc-898-6-0\" class=\"panel-grid-cell\"><div id=\"panel-898-6-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"12\"><div class=\"panel-widget-style panel-widget-style-for-898-6-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-898\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channels in auto-immune diseases<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-6-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-6-1\"><div id=\"panel-898-6-1-0\" class=\"so-panel widget widget_specifications-theme-widget panel-first-child panel-last-child\" data-index=\"13\"><div class=\"so-widget-specifications-theme-widget so-widget-specifications-theme-widget-default-d75171398898-898\">    <div class=\"specifications-list\">\n                    <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Myasthenia Gravis<\/div>\n                <div class=\"col-6 px-0 value\">alpha1 nAChR  (neuromuscular junction)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Lambert-Eaton myasthenia<\/div>\n                <div class=\"col-6 px-0 value\">Ca<sub>V<\/sub>2.1, Ca<sub>V<\/sub>2.2 (neuromuscular junction)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Person-on-fire<\/div>\n                <div class=\"col-6 px-0 value\">NMDA receptors (CNS neurons)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Stiff man, startle disease<\/div>\n                <div class=\"col-6 px-0 value\">Glycine and GABA<sub>A<\/sub> receptors (Spinal cord)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Rasmussen\u2019s encephalitis<\/div>\n                <div class=\"col-6 px-0 value\">NMDA receptors and alpha7 nAChR (Brain hemisphere)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Rheumatoid arthritis<\/div>\n                <div class=\"col-6 px-0 value\">K<sub>Ca<\/sub>1.1 and K<sub>V<\/sub>1.3<\/div>\n            <\/div>\n                <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-7\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-898-7\"><div id=\"pgc-898-7-0\" class=\"panel-grid-cell\"><div id=\"panel-898-7-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"14\"><div class=\"panel-widget-style panel-widget-style-for-898-7-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-898\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\"><\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-7-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-7-1\"><div id=\"panel-898-7-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"15\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-898-8\" class=\"panel-grid panel-no-style\"><div id=\"pgc-898-8-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-898-8-1\" class=\"panel-grid-cell\"><div id=\"panel-898-8-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"16\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Assay platforms<\/strong> for<\/h2>\n<h2>immunology and immuno-oncology<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-898-9\" class=\"panel-grid panel-no-style\"><div id=\"pgc-898-9-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-898-9-0\"><div id=\"panel-898-9-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"17\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-898-9-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-898\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tElectrophysiology and impedance applications\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-898-9-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-898-9-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"18\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Our various platforms can be used to study immune cells, find treatments for auto-immune diseases, and inflammation, and support immune-oncology research.<\/p>\n<p>Automated patch clamp electrophysiology can record voltage- and ligand-gated ion channels in immune cells, discover how they regulate and respond to cell activation, and identify drugs to treat inflammatory and auto-immune diseases. Modulators and blockers of potassium channels and cation channels (e.g. Orai-Stim), such as ShK toxin K<sub>V<\/sub>1.3 inhibitors, have been tested in cell lines and T-cells, on <a href=\"\/products\/port-a-patch\/\">Port-a-Patch<\/a> and <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a>.<\/p>\n<p>Impedance-based technology is emerging as a new, powerful tool to monitor the efficiency of various immune-oncology treatments, such as CAR T. Nanion\u2019s <a href=\"\/products\/atlaz\/\" target=\"_blank\" rel=\"noopener\">AtlaZ impedance system<\/a> enables label-free, continuous, real-time monitoring of cancer immune therapy effects in acute and chronic experiments that mirror <em>in vivo<\/em> treatment regimes, in a high throughput manner (simultaneous recordings of six 96 well plates). This approach gives researchers the necessary tools to gain deeper access to the kinetic and phenotypic cellular responses.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-898-9-1-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"19\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-898\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/resource-library\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tResource library\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-898-9-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-898-10\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-898-10\"><div id=\"pgc-898-10-0\" class=\"panel-grid-cell\"><div id=\"panel-898-10-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"20\"><div id=\"pl-w64a3cfef00a6e\" class=\"panel-layout\"><div id=\"pg-w64a3cfef00a6e-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w64a3cfef00a6e-0\"><div id=\"pgc-w64a3cfef00a6e-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w64a3cfef00a6e-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w64a3cfef00a6e-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w64a3cfef00a6e-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w64a3cfef00a6e-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w64a3cfef00a6e-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w64a3cfef00a6e-1\"><div id=\"pgc-w64a3cfef00a6e-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w64a3cfef00a6e-1-0\"><div id=\"panel-w64a3cfef00a6e-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w64a3cfef00a6e-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Sonja St\u00f6lzle-Feix (<span class=\"ui-provider fz b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak\" dir=\"ltr\">Director Scientific Affairs and Product Manager of Cell analytics systems<\/span>). Sonja is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w64a3cfef00a6e-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w64a3cfef00a6e-1-1\"><div id=\"panel-w64a3cfef00a6e-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w64a3cfef00a6e-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:Sonja@nanion.de\">Sonja@nanion.de<\/a><\/strong><br>\nor call: <strong>+49 89 2190 95-075<\/strong><br>\nor connect via <a href=\"https:\/\/www.linkedin.com\/in\/sonja-st%C3%B6lzle-feix-96472514\/\" target=\"_blank\" rel=\"noopener\"><strong>LinkedIn<\/strong><\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w64a3cfef00a6e-1-2\" class=\"panel-grid-cell\"><div 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class=\"arrow-link\">Read more<\/div>\n                            <\/a>\n                        <\/div>\n                    <\/div>\n                <\/div>\n                            <div class=\"item\" style=\"width:390px\">\n                                        <div class=\"row no-margin\">\n                        <div class=\"col-12 news-thumbnail\">\n                                                            <a href=\"https:\/\/nanion.com\/zh-hans\/news\/webinar-investigating-sarcoplasmic-reticulum-ca2-atpase-on-ssme\/\">\n                                    <noscript><img decoding=\"async\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-Tadini-scaled.png\"><\/noscript><img decoding=\"async\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" 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});\n<\/script><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Immune diseases Finding cures for cancer and auto-immun [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":98,"menu_order":33,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-898","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/898","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/comments?post=898"}],"version-history":[{"count":120,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/898\/revisions"}],"predecessor-version":[{"id":18488,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/898\/revisions\/18488"}],"up":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/pages\/98"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=898"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}