{"id":870,"date":"2022-08-30T08:15:32","date_gmt":"2022-08-30T08:15:32","guid":{"rendered":"http:\/\/ionchanneltargets.com\/?page_id=870"},"modified":"2025-10-23T06:50:18","modified_gmt":"2025-10-23T04:50:18","slug":"transporter-targets","status":"publish","type":"page","link":"https:\/\/nanion.com\/zh-hans\/science-hub\/application-areas\/transporter-targets\/","title":{"rendered":"Transporter targets"},"content":{"rendered":"<div id=\"pl-870\" class=\"panel-layout\"><div id=\"pg-870-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-870-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-870-0-0\" class=\"panel-grid-cell\"><div id=\"panel-870-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-870\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Transporter targets<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tResearch beyond ion channels.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-870-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-870-1\"><div id=\"pgc-870-1-0\" class=\"panel-grid-cell\"><div id=\"panel-870-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"white-text panel-widget-style panel-widget-style-for-870-1-0-0\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-870\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1720933210{\n        width: ;\n        height: ;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1720933210 .image{\n        width: calc(100% + );\n        height: calc(100% + );\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-1172576915\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1720933210\" data-mark>\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/22E4376w.jpg\" style><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/22E4376w.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2><strong>Transporters: The Future of Medicine <\/strong><\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                Membrane transporters are increasingly being recognized as important players in human health and disease. SLC transporters make the majority of human transport proteins, followed by ion channels and pumps. With their function still being discovered, many SLC transporters have been promising drug targets for diseases such as diabetes, cancer, neurological disorders (epilepsy, Parkinson\u2019s, and Alzheimer\u2019s) and immunological disorders, cardiovascular and metabolic diseases. In addition, some transporters function as drug transporters and also play a crucial role in pharmacokinetics and how a potential drug is distributed in the human body.\n\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-1172576915 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-1172576915 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-1172576915\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-1172576915\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-870-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-870-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-870-2-1\" class=\"panel-grid-cell\"><div id=\"panel-870-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Diversity <\/strong>of Membrane Transporters<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-870-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-870-3\"><div id=\"pgc-870-3-0\" class=\"panel-grid-cell\"><div id=\"panel-870-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-870-3-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-870\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Functional and Phylogenetic Classification <\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-870-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-870-3-1\"><div id=\"panel-870-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Across all species, transport proteins are organized into three major classes according to their energy coupling mechanisms: channels, pumps, and transporters according to the Transport Classification (TC) system. It is the most comprehensive system to appreciate the number and diversity of membrane transport proteins. In contrast to ion channels, transporters have more diverse substrates (amino acids, sugars, and other metabolites, neurotransmitters, vitamins, cofactors, and transition metals), in addition to their various modes of action.<\/p>\n<p>Channels mediate substrate translocation through passive flux along their electrochemical gradient. Pumps are primary active transport proteins, using a primary energy source such as ATP or light to mediate substrate flux. Except for uniporters, transporters are secondary active transport proteins, coupling the flux of one substrate along its electrochemical gradient to drive the transport of <span class=\"ui-provider ux b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak\" dir=\"ltr\">another substrate<\/span> against its electrochemical gradient. Translocation of the two substrates may occur in the same direction (cotransporter or symporter) or in opposite directions (antiporter or exchanger).<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-870-4\" class=\"panel-grid panel-no-style\"><div id=\"pgc-870-4-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-870-4-0\"><div id=\"panel-870-4-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"5\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-870-4-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-810623cd80db-870\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tComplexity\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-870-4-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Transporters have diverse substrates, as well as mechanisms of action. After substrate binding, transporters undergo multiple conformational transitions, allowing for alternating access of the substrate binding sites to either side of the membrane. These transitions involve mechanisms such as rocker-switch movements, gated pores, or elevators, that switch between outward- and inward-facing transporter states. Adding substrate-bound and -free states and often additional high and low-energy transporter intermediates, typical \u2018simplified\u2019 transport cycles consist of four to ten states. Given specific rate constants for substrate binding and release steps and all subsequent transitions, transport cycles are way more complicated to study.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-870-4-0-2\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-870\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/target-database\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\">\n\t\t<span>\n\t\t\t\n\t\t\tTarget database\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-870-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-870-4-1\"><div id=\"panel-870-4-1-0\" class=\"so-panel widget widget_image-out-container-theme-widget panel-first-child panel-last-child\" data-index=\"8\"><div class=\"panel-widget-style panel-widget-style-for-870-4-1-0\"><div class=\"so-widget-image-out-container-theme-widget so-widget-image-out-container-theme-widget-default-d75171398898-870\">    <div class=\"img-out-container-warp\" style=\"max-width:495px;position:relative;transform: translateX(-0px); float:left; left:0; z-index: 10;\">\n        <div class=\"dotted-grid bottom-right mobile-disable-dotted-grid-aimation \" data-translatemarky=\"103\" data-translatemarkx=\"100\" data-duration=\"180%\" data-mobilemargin=\"no\" style=\"width:450px;height:450px; max-width:100%;\"><\/div>        <div class=\"img-out-container\">\n            <noscript><img decoding=\"async\" width=\"990\" height=\"720\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720.jpg\" class=\"attachment-full size-full\" alt srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720.jpg 990w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720-300x218.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720-768x559.jpg 768w\" sizes=\"(max-width: 990px) 100vw, 990px\"><\/noscript><img decoding=\"async\" width=\"990\" height=\"720\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20990%20720%22%3E%3C%2Fsvg%3E\" class=\"attachment-full size-full lazyload\" alt srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20990%20720%22%3E%3C%2Fsvg%3E 990w\" sizes=\"(max-width: 990px) 100vw, 990px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720.jpg 990w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720-300x218.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720-768x559.jpg 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Transporter-cycle_990x720.jpg\">        <\/div>\n                            <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-870-5\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-870-5\" data-stretch-type=\"full\"><div id=\"pgc-870-5-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-870-5-0\"><div id=\"panel-870-5-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"9\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-870-5-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-870\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tSURFE<sup>2<\/sup>R technology\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-870-5-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-870-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Automated <\/strong>Transporter Measurements<\/h2>\n<\/div>\n<\/div><\/div><div id=\"panel-870-5-1-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"11\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Most transport proteins are accessible using our SURFE<sup>2<\/sup>R technology, specifically all types of electrogenic transporters (symporters, exchangers, uniporters), ligand-gated and leak channels, and ATPases.<\/p>\n<p>The SURFE<sup>2<\/sup>R uses capacitive sensors and is not able to perform voltage steps to trigger ion translocation but uses a perfusion system to provide substrate gradients. The SURFE<sup>2<\/sup>R technology clearly differentiates from patch clamp through the measurement of substrate-induced currents making pre-steady-state kinetics of substrate binding accessible. For this reason, patch clamp technology would be a better choice if voltage-gated ion channels are in focus.<\/p>\n<p>On the other hand, the SURFE<sup>2<\/sup>R allows measuring slow transporters and transporters from intracellular membranes, both of which are usually hardly accessible via patch clamp technology. The <a href=\"\/products\/surfer-96se\/\">SURFE<sup>2<\/sup>R 96SE<\/a> allows for drug screening on transporters in a 96-sensor well format, while the <a href=\"\/products\/surfe2r-n1\/\">SURFE<sup>2<\/sup>R N1<\/a> was designed for its high assay flexibility and is easy to use.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-870-5-1-2\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"12\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-870\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/product-categories\/membrane-biophysics\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\">\n\t\t<span>\n\t\t\t\n\t\t\tSee our product areas\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-870-5-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-870-6\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-870-6\"><div id=\"pgc-870-6-0\" class=\"panel-grid-cell\"><div id=\"panel-870-6-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"13\"><div id=\"pl-w641288cb2a11e\" class=\"panel-layout\"><div id=\"pg-w641288cb2a11e-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w641288cb2a11e-0\"><div id=\"pgc-w641288cb2a11e-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w641288cb2a11e-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w641288cb2a11e-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w641288cb2a11e-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w641288cb2a11e-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w641288cb2a11e-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w641288cb2a11e-1\"><div id=\"pgc-w641288cb2a11e-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w641288cb2a11e-1-0\"><div id=\"panel-w641288cb2a11e-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w641288cb2a11e-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Maria Barthmes (Product Manager of the SURFE<sup>2<\/sup>R product family). Maria is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w641288cb2a11e-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w641288cb2a11e-1-1\"><div id=\"panel-w641288cb2a11e-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w641288cb2a11e-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:Maria.Barthmes@nanion.de\">Maria.Barthmes@nanion.de<\/a><\/strong><br>\nor call: <strong>+49 89 2190 95-068<\/strong><br>\nor connect via <a href=\"https:\/\/www.linkedin.com\/in\/maria-barthmes-840b246b\/\" target=\"_blank\" rel=\"noopener\"><strong>LinkedIn<\/strong><\/a><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w641288cb2a11e-1-2\" class=\"panel-grid-cell\"><div id=\"panel-w641288cb2a11e-1-2-0\" class=\"so-panel widget widget_image-out-container-theme-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-image-out-container-theme-widget so-widget-image-out-container-theme-widget-default-d75171398898\">    <div class=\"img-out-container-warp\" style=\"max-width:420px;position:absolute;transform: translateX(65px); float:right; right:0; z-index: 10;\">\n        <style>.lazy-loader-background-element-1.lazyloaded{ background-image: url('https:\/\/nanion.com\/wp-content\/uploads\/2022\/10\/Dotted-grid-2-1.svg') !important; }<\/style><noscript><style>.lazy-loader-background-element-1.lazyload{ background-image: url('https:\/\/nanion.com\/wp-content\/uploads\/2022\/10\/Dotted-grid-2-1.svg') !important; }<\/style><\/noscript><div class=\"dotted-grid bottom-left mobile-disable-dotted-grid-aimation  lazyload lazy-loader-background-element-1 \" data-translatemarky=\"100\" data-translatemarkx=\"-100\" data-duration=\"180%\" 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