{"id":138,"date":"2022-07-27T05:57:46","date_gmt":"2022-07-27T05:57:46","guid":{"rendered":"http:\/\/ionchanneltargets.com\/?page_id=138"},"modified":"2025-10-23T06:40:30","modified_gmt":"2025-10-23T04:40:30","slug":"cardiac-safety","status":"publish","type":"page","link":"https:\/\/nanion.com\/zh-hans\/science-hub\/therapeutic-areas\/cardiac-safety\/","title":{"rendered":"Cardiac safety"},"content":{"rendered":"<div id=\"pl-138\" class=\"panel-layout\"><div id=\"pg-138-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-138-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-138-0-0\" class=\"panel-grid-cell\"><div id=\"panel-138-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-138\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Cardiac safety<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tSafeguarding the path to breakthrough medications.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-138-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-138-1\"><div id=\"pgc-138-1-0\" class=\"panel-grid-cell\"><div id=\"panel-138-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-138\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1987961031{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1987961031 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-1169168386\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1987961031\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_840x1040-2.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_840x1040-2.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2><strong>Heartbeats and safety<\/strong>: Charting the course of drug development<\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Novel drug discovery begins at the preclinical laboratory bench as it is essential to answer basic questions concerning compound safety if a new compound is to progress to pharmaceutical development. Before any compound can be considered for dosing in healthy people, it undergoes a series of basic research <em>in vitro<\/em> and <em>in vivo<\/em> assays to determine its potential to cause toxicity against human organ systems, such as the heart, liver, or nervous system. It is of paramount importance to maximally de-risk its safety profile as early as possible in discovery to protect patients from unanticipated adverse events in the clinic, as well as control sky-rocketing development costs. The withdrawal of several drugs from the market in the last two<\/p>            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-1169168386 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-1169168386 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-1169168386\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-1169168386\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-138-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-138-2-1\" class=\"panel-grid-cell\"><div id=\"panel-138-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Cardiac Safety:<\/strong> The major<br>\nhurdle for new drugs in<br>\ndevelopment<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-138-3\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-3-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-138-3-0\"><div id=\"panel-138-3-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"3\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-138-3-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-138\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tCatching <br>arrythmias\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-138-3-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-138-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>De-risking proarrhythmic potential of drugs that could produce a fatal ventricular arrythmia known as Torsade de Pointes (TdP) has been front and center of drug development for over two decades. Cardiac safety pharmacologists use a combination of <em>in vivo<\/em> and in <em>vitro<\/em> assays to predict the risk of new therapeutics producing potentially fatal ventricular cardiac arrythmias. In particular, <em>in vivo<\/em> prolongation of the QT interval measured during an electrocardiogram (ECG) &nbsp;is the gold standard surrogate marker for flagging proarrhythmic efficacy of new compounds.<\/p>\n<p>However, the molecular and cellular mechanisms linking QT interval prolongation and TdP are complex and not fully understood. We know that many compounds that evoke TdP in patients have unequivocally been shown to inhibit a cardiac potassium ion channel called hERG. The biophysical consequence of hERG inhibition at the cellular level is delayed repolarization of the cardiac action potential which may cause TdP. However, the correlation is imperfect, because there are also example compounds that potently block the hERG channel, yet are not proarrhythmic in humans, such as the well-known L-type calcium channel inhibitor, Verapamil, still used by physicians to control blood pressure in millions of patients worldwide. Nevertheless, the present preclinical regulatory guidelines known as&nbsp; ICH S7B mandate a patch-clamp electrophysiology test of compounds against the hERG ion channel and an in vivo QT test assessment. Because both of these tests are at best only surrogate markers of proarrhythmic activity of a compound, they highlight the important unmet need for the introduction of additional assays that better predict TdP. This insufficient availability of more predictive assays was, in 2013, an important catalyst for the formation of the \u201cComprehensive In Vitro Proarrhythmic Assay (CiPA) initiative\u201d.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-138-3-1-1\" class=\"so-panel widget widget_sow-image panel-last-child\" data-index=\"5\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-138\">\n<div class=\"sow-image-container\">\n\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1.png\" width=\"1532\" height=\"817\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1.png 1532w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-300x160.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-1024x546.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-768x410.png 768w\" sizes=\"(max-width: 1532px) 100vw, 1532px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201532%20817%22%3E%3C%2Fsvg%3E\" width=\"1532\" height=\"817\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201532%20817%22%3E%3C%2Fsvg%3E 1532w\" sizes=\"(max-width: 1532px) 100vw, 1532px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1.png 1532w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-300x160.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-1024x546.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1-768x410.png 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CIPA1.png\">\n\t<\/div>\n\n<\/div><\/div><\/div><div id=\"pgc-138-3-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-138-4\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-4-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-138-4-0\"><div id=\"panel-138-4-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"6\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-138-4-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-138\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tCardiac Safety<br>(CiPA)\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-138-4-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-138-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The Comprehensive In Vitro Proarrhythmic Assay (<a href=\"https:\/\/cipaproject.org\/\" target=\"_blank\" rel=\"noopener\">CiPA<\/a>) initiative is an ongoing global, public, and private collaboration with the aim of updating the existing cardiac safety testing paradigm (hERG and QT testing only) to better evaluate arrhythmia risk and removing the need for routine exhausting and expensive TQT studies. The CiPA work streams include:&nbsp;<strong>In Silico<\/strong>,&nbsp;<strong>Myocyte<\/strong>,&nbsp;<strong>Ion Channel<\/strong>, and&nbsp;<strong>Clinical Translation&nbsp;<\/strong>working groups. CiPA is focused on producing a broad standardized ion channel assay approach, incorporating defined patch-clamp assays for multiple important cardiac ion channels (I<sub>Kr<\/sub>&nbsp;(hERG), I<sub>Ca<\/sub>&nbsp;(L-type; Cav1.2), and I<sub>Na<\/sub> (Nav1.5 peak and late current)).&nbsp;These results are being fed into an <em>in-silico<\/em> model of the human ventricular action potential that hopefully more accurately predicts the proarrhythmic efficacy of new compounds. And very importantly, the CiPA studies are systematically evaluating the compounds from the patch-clamp\/in-silico experiments in human stem cell-derived cardiomyocytes using a variety of functional assay platforms with the primary goal of defining novel proarrhythmic predictive assays that identify changes in ventricular repolarization not necessarily anticipated by the ion channel\/in-silico modeling predictions alone. The Steering Team is comprised of partners from the <a href=\"https:\/\/www.fda.gov\/\" target=\"_blank\" rel=\"noopener\">US FDA<\/a>, <a href=\"https:\/\/hesiglobal.org\/\" target=\"_blank\" rel=\"noopener\">HESI<\/a>, <a href=\"https:\/\/cardiac-safety.org\/\" target=\"_blank\" rel=\"noopener\">CSRC<\/a>, <a href=\"https:\/\/safetypharmacology.org\/\" target=\"_blank\" rel=\"noopener\">SPS<\/a>, <a href=\"http:\/\/www.nihs.go.jp\/english\/index.html\" target=\"_blank\" rel=\"noopener\">Japan NIHS<\/a>, <a href=\"https:\/\/www.pmda.go.jp\/english\/index.html\" target=\"_blank\" rel=\"noopener\">PMDA<\/a>, <a href=\"https:\/\/www.ema.europa.eu\/en\" target=\"_blank\" rel=\"noopener\">EMA<\/a> and <a href=\"https:\/\/www.canada.ca\/en\/health-canada.html\" target=\"_blank\" rel=\"noopener\">Health Canada<\/a>. A number of&nbsp;participating organizations, amongst them Nanion Technologies, build the backbone of the initiative. &nbsp;We eagerly anticipate and await the ongoing publication of the CiPA studies in 2023 and beyond.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>Recommended links<\/strong>:<\/p>\n<p><a href=\"https:\/\/www.fda.gov\/drugs\/news-events-human-drugs\/new-approaches-integrated-nonclinical-clinical-qtproarrhythmic-risk-assessment-10152020-10162020\" target=\"_blank\" rel=\"noopener\"><em>In-vitro<\/em> best practices and ICH S7B considerations, hosted by FDA<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1056871920302136?via%3Dihub\">Reliable identification of cardiac liability in drug discovery using automated patch clamp, publication<\/a><\/p>\n<p><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/abs\/pii\/S1056871921001787\">Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II, publication: Best practices for Na<sub>v<\/sub>1.5 peak current in a high throughput screening environment<\/a><\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-138-4-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-138-5\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-5-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-138-5-1\" class=\"panel-grid-cell\"><div id=\"panel-138-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Comprehensive<\/strong> experimental<br>\napproach to cardiac safety<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-138-6\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-6-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-138-6-0\"><div id=\"panel-138-6-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"9\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-138-6-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-138\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tAPC, extracellular recordings and contractility\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-138-6-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-138-6-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Nanion is a committee member of the Ion Channel HTS Team and a participant in the Myocyte Working Group. Nanion has a long-standing interest and extensive experience in automated patch clamp screening of cardiac ion channels. The Ion Channel Work Group finalized its phase I study in 2017. Besides further external sites, Nanion in Germany, USA, and Japan participated with the <a href=\"\/products\/patchliner\/\">Patchliner<\/a> and the <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384PE<\/a> in this study.&nbsp; Label-free contractility and extracellular field potential recordings of stem cell-derived cardiomyocytes (iPSC-CMs) are also available in our portfolio and were part of the Myocyte Working Group (<a href=\"\/products\/cardioexcyte-96\/\">CardioExcyte 96<\/a> and <a href=\"\/products\/flexcyte-96\/\">FLEXcyte 96<\/a>). Our instruments are used for safety screening by major pharmaceutical companies and CROs worldwide and we are happy to assist you in setting up your CiPA assays.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-138-6-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-138-7\" class=\"panel-grid panel-no-style\"><div id=\"pgc-138-7-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-138-7-0\"><div id=\"panel-138-7-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"11\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-138-7-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-138\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tHTS ion channel hERG results phase 1, excerpt\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-138-7-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-138-7-1-0\" class=\"so-panel widget widget_sow-image panel-first-child\" data-index=\"12\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-138\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720.png\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720.png\" width=\"1200\" height=\"720\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720.png 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-300x180.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-1024x614.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-768x461.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" title=\"CiPA overview APC\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E\" width=\"1200\" height=\"720\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" title=\"CiPA overview APC\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720.png 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-300x180.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-1024x614.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720-768x461.png 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CiPA_overview_1200x720.png\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><div id=\"panel-138-7-1-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"13\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-138\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/target-database\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tTarget database\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-138-7-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-138-8\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-138-8\"><div id=\"pgc-138-8-0\" class=\"panel-grid-cell\"><div id=\"panel-138-8-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"14\"><div id=\"pl-w64a3cfe0bcddd\" class=\"panel-layout\"><div id=\"pg-w64a3cfe0bcddd-0\" 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panel-row-style-for-w64a3cfe0bcddd-1\"><div id=\"pgc-w64a3cfe0bcddd-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w64a3cfe0bcddd-1-0\"><div id=\"panel-w64a3cfe0bcddd-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w64a3cfe0bcddd-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Sonja St\u00f6lzle-Feix (<span class=\"ui-provider fz b c d e f g h i j k l m n o p q r s t u v w x y z ab ac ae af ag ah ai aj ak\" dir=\"ltr\">Director Scientific Affairs and Product Manager of Cell analytics systems<\/span>). 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});\n<\/script><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Safeguarding the path to breakthrough 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