{"id":11220,"date":"2023-05-17T07:41:21","date_gmt":"2023-05-17T07:41:21","guid":{"rendered":"https:\/\/www.nanion.de\/?page_id=11220"},"modified":"2026-02-03T14:14:19","modified_gmt":"2026-02-03T12:14:19","slug":"lysosomal-diseases","status":"publish","type":"page","link":"https:\/\/nanion.com\/zh-hans\/science-hub\/therapeutic-areas\/lysosomal-diseases\/","title":{"rendered":"Lysosomal diseases"},"content":{"rendered":"<div id=\"pl-11220\" class=\"panel-layout\"><div id=\"pg-11220-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-11220-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-11220-0-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-11220\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Lysosomal diseases<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tIon channels and transporters as key players.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-11220-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-11220-1\"><div id=\"pgc-11220-1-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-11220\"><style>\n    \/*.read-more-section .image-wrapper #box-img-916385533{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-916385533 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-345335207\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-916385533\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/05\/Lysosomes_840x1040.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/05\/Lysosomes_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2><strong>Unlocking the Secrets of Lysosomes:<\/strong> Ion Channels and Transporters in Lysosomal Diseases<\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Lysosomes are intracellular organelles which serve as the digestive system of the cell. Lysosomes degrade material taken up from outside the cell, as well as obsolete components of the cell itself. The inside of the lysosome is highly acidic, which is essential for the function of the lysosomal hydrolases. The acidic pH is maintained by a proton pump in the lysosomal membrane which actively transports H<sup>+<\/sup> ions into the lysosome. Other ion channels and transporters, such as TMEM175 and TRPML, are also present in the lysosomal membrane and mutations in these proteins have been linked to various diseases including neurodegenerative diseases like Parkinson\u2019s and Alzheimer\u2019s disease, and cancer.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-345335207 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-345335207 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-345335207\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-345335207\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-11220-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-11220-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-11220-2-1\" class=\"panel-grid-cell\"><div id=\"panel-11220-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>The rapidly evolving field&nbsp;<\/strong>of lysosomal<\/h2>\n<h2>ion channel and transporter research<\/h2>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-11220-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-11220-3\"><div id=\"pgc-11220-3-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-11220-3-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-11220\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Parkinson\u00b4s disease risk protein TMEM175<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-11220-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-11220-3-1\"><div id=\"panel-11220-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Recent developments in neurodegenerative disease research very clearly show that no detail is too small to miss. Focusing even on tiny structures in the cellular function, such as the cellular organelles (lysosomes and mitochondria) can bring significant advancement in helping affected patients. The involvement of impaired lysosomal and mitochondrial function in Parkinson\u00b4s disease (PD) is not new. However, TMEM175 a novel, constitutively active ion channel involved in regulating lysosomal pH and autophagy, emerged as a highly relevant potential target for the treatment of PD. Patients carrying a mutation in the TMEM175 gene, carry significant risk for Parkinson\u2019s disease development and earlier age-of-onset, presumably due to compromised lysosomal and mitochondrial function, leading to increasing aggregation of insoluble proteins such as phosphorylated \u03b1-synuclein. The lack of specific experimental tools has hindered further investigation into the exact role of TMEM175 in normal lysosomal function and pathological processes. However, successful recordings of TMEM175 have been performed using automated patch clamp and solid-supported membrane- (SSM-) based electrophysiology, opening new avenues for deciphering organelle function.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-11220-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-11220-4\"><div id=\"pgc-11220-4-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-4-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"5\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-11220\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">DCPIB dose response curve for K<sup>+<\/sup> flux through TMEM175 in lysosomes<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-11220-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-11220-4-1\"><div id=\"panel-11220-4-1-0\" class=\"so-panel widget widget_sow-image panel-first-child\" data-index=\"6\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-11220\"><\/div><\/div><div id=\"panel-11220-4-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Figure shows DCPIB&nbsp;dose response curve (left) and individual current traces (right) for K<sup>+<\/sup> flux through TMEM175 in lysosomes purified from TMEM175&nbsp;overexpressing HEK293 cell culture. From the dose dependent peak currents we established&nbsp;EC50 and Imax values for the&nbsp;modulation of K<sup>+<\/sup> flux&nbsp;by DCPIB.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-11220-5\" class=\"panel-grid panel-no-style\"><div id=\"pgc-11220-5-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-11220-5-0\"><div id=\"panel-11220-5-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"8\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-11220-5-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-11220\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tTRPML-1 and lysosomal storage disorders\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-11220-5-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-11220-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"9\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>TRPML1 (Transient Receptor Potential Mucolipin 1) is an important cation channel that has gained attention from the medical and scientific communities due to its vital role in cellular physiology and its potential as a therapeutic target.<\/p>\n<p>TRPML1 is primarily found within the lysosomes, the recycling centers of our cells. It plays a crucial role in physiology as a sensor for reactive oxygen species and is an essential player of lysosomal adaption in situations of nutrient starvation. TRPML1 exhibits a unique ion selectivity, mediating calcium efflux, but also the passage of sodium, and potassium ions. Understanding the intricate gating mechanisms and ion conductance properties of TRPML1 holds the key to unraveling its physiological functions and potentially developing targeted therapies for diseases associated with its malfunction. Dysfunctions in TRPML1 have been linked to lysosomal storage disorders such as Mucolipidosis Type IV, which affect multiple organ systems and manifest as developmental delays, motor impairments, and visual problems.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-11220-5-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-11220-6\" class=\"panel-grid panel-no-style\"><div id=\"pgc-11220-6-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-11220-6-0\"><div id=\"panel-11220-6-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"10\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-11220-6-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-11220\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tLysosomal ion channels and transporters in disease\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-11220-6-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-11220-6-1-0\" class=\"so-panel widget widget_specifications-theme-widget panel-first-child\" data-index=\"11\"><div class=\"so-widget-specifications-theme-widget so-widget-specifications-theme-widget-default-d75171398898-11220\">    <div class=\"specifications-list\">\n                    <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">TMEM175*<\/div>\n                <div class=\"col-6 px-0 value\">Parkinson\u2019s disease<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">TRPML1*<\/div>\n                <div class=\"col-6 px-0 value\">Mucolipidosis Type IV leading to hepatosplenomegaly, dysmorphic features and neurological disorders<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">ClC-7*<\/div>\n                <div class=\"col-6 px-0 value\">Osteopetrosis, neuronal ceroid lipofuscinoses (LSD), neurodegeneration<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Cystinosin*<\/div>\n                <div class=\"col-6 px-0 value\">Cystinosis (LSD)<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">SLC15a4*<\/div>\n                <div class=\"col-6 px-0 value\">Hypotrichosis 4, Systemic Lupus Erythematosus<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Sialin<\/div>\n                <div class=\"col-6 px-0 value\">Sialic Acid Storage Disease (LSD), muscular, cerebellar and CNS disorders<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">Presenilin-1 dependent v-ATPase<\/div>\n                <div class=\"col-6 px-0 value\">Alzheimer disease<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">TPC1\/2<\/div>\n                <div class=\"col-6 px-0 value\">Parkinson's disease, non-alcoholic fatty liver disease, Ebola infection, cancer, cardiac dysfunction and diabetes<\/div>\n            <\/div>\n                        <div class=\"row mx-0 specification-item\">\n                <div class=\"col-6 px-0 label\">ATP13A2<\/div>\n                <div class=\"col-6 px-0 value\">Parkinson\u2019s disease<\/div>\n            <\/div>\n                <\/div>\n    <\/div><\/div><div id=\"panel-11220-6-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"12\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>*Listed targets have been validated on SURFE<sup>2<\/sup>R instruments. (LSD=lysosomal storage disease)<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-11220-6-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-11220-7\" class=\"panel-grid panel-no-style\"><div id=\"pgc-11220-7-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-11220-7-1\" class=\"panel-grid-cell\"><div id=\"panel-11220-7-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"13\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Techniques for <\/strong><strong>organelle research<\/strong><\/h2>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-11220-8\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-11220-8\"><div id=\"pgc-11220-8-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-8-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"14\"><div class=\"panel-widget-style panel-widget-style-for-11220-8-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-11220\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Recording lysosomes<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-11220-8-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-11220-8-1\"><div id=\"panel-11220-8-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"15\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Technologies such as <a href=\"\/product-categories\/automated-patch-clamp\/\">automated patch clamp (APC)<\/a> or <a href=\"\/products\/surfe2r-n1\/how-it-works\/\">solid-supported membrane- (SSM-) based electrophysiology<\/a> offer options for recording activity of ion channels and transporters located even in small cellular structures, such as lysosomes at high throughput, relevant for drug discovery and validation<strong>.<\/strong><\/p>\n<p>Automated patch clamp platforms can be used to study lysosomal ion channels. TPC1\/2 ion channels in lysosomes have been recorded using the <a href=\"\/products\/port-a-patch\/\">Port-a-Patch<\/a>. Upscaling the throughput to <a href=\"\/products\/patchliner\/\">Patchliner<\/a> and <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a> allows for faster ion channel mutation screening as done by recording plasma membrane TMEM175 in wild type and mutated cell.<\/p>\n<p>The&nbsp;<a href=\"\/products\/surfe2r-n1\/\"><strong>SURFE<sup>2<\/sup>R N1<\/strong><\/a>&nbsp;and&nbsp;<a href=\"\/products\/surfer-96se\/\"><strong>SURFE<sup>2<\/sup>R 96SE<\/strong><\/a> , both applying SSM-based electrophysiology, can measure ion and substrate flow by transporters and ion channels directly from intact lysosomes. Such measurements have been successfully performed for TMEM175, TRPML1 and ClC-7. The SSM-based approach allows for stable and robust recordings from proteins residing in organellar membranes with a throughput of up to 10,000 data points per day.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-11220-9\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-11220-9\"><div id=\"pgc-11220-9-0\" class=\"panel-grid-cell\"><div id=\"panel-11220-9-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"16\"><div id=\"pl-w6981e69b9be18\" class=\"panel-layout\"><div id=\"pg-w6981e69b9be18-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e69b9be18-0\"><div id=\"pgc-w6981e69b9be18-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w6981e69b9be18-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w6981e69b9be18-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6981e69b9be18-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6981e69b9be18-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6981e69b9be18-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e69b9be18-1\"><div id=\"pgc-w6981e69b9be18-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e69b9be18-1-0\"><div id=\"panel-w6981e69b9be18-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6981e69b9be18-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Cecilia George (Global Head of SURFE<sup>2<\/sup>R Sales \/ Senior Scientist). Cecilia is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e69b9be18-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e69b9be18-1-1\"><div id=\"panel-w6981e69b9be18-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6981e69b9be18-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:cecilia.george@nanion.de\">cecilia.george@nanion.de<\/a><\/strong><\/p>\n<p>or connect via&nbsp;<strong><a href=\"https:\/\/www.linkedin.com\/in\/cecilia-george-75102ba\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e69b9be18-1-2\" class=\"panel-grid-cell\"><div id=\"panel-w6981e69b9be18-1-2-0\" class=\"so-panel widget 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});\n<\/script><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Lysosomal diseases Ion channels and transporters as key 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