{"id":19822,"date":"2026-10-06T15:14:22","date_gmt":"2026-10-06T13:14:22","guid":{"rendered":"https:\/\/nanion.com\/?post_type=news&#038;p=19822"},"modified":"2026-10-07T15:40:59","modified_gmt":"2026-10-07T13:40:59","slug":"webinar-investigating-sarcoplasmic-reticulum-ca2-atpase-on-ssme","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/webinar-investigating-sarcoplasmic-reticulum-ca2-atpase-on-ssme\/","title":{"rendered":"Webinar: Investigating sarcoplasmic reticulum Ca<sup>2+<\/sup>-ATPase using SSME"},"content":{"rendered":"<div id=\"pl-19822\" class=\"panel-layout\"><div id=\"pg-19822-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19822-0-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-0-0-0\" class=\"so-panel widget widget_text panel-first-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p data-pm-slice=\"1 1 []\">Part of the <strong>Beyond the Plasma Membrane<\/strong> webinar series. <a href=\"https:\/\/nanion.com\/news\/webinar-series-beyond-the-plasma-membrane\/\">Explore all sessions<\/a><\/p>\n<p data-pm-slice=\"1 1 []\"><strong>Date:<\/strong>&nbsp; Wednesday, November 18, 2026<br>\n<strong>Time:<\/strong> 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n<p data-pm-slice=\"1 1 []\">How can SSM-based electrophysiology help uncover the transport mechanisms of intracellular membrane proteins?<\/p>\n<p>Join <strong>Professor Francesco Tadini Buoninsegni<\/strong> from the University of Florence for a webinar exploring the sarcoplasmic reticulum Ca\u00b2\u207a-ATPase (SERCA), its role in intracellular calcium homeostasis, and how solid supported membrane (SSM)-based electrophysiology can provide mechanistic insights into its transport cycle and interactions with pharmacologically relevant compounds.<\/p>\n<\/div>\n\t\t<\/div><div id=\"panel-19822-0-0-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"1\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-19822\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\" download>\n\t\t<span>\n\t\t\t\n\t\t\tRegister here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-19822-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19822-1\"><div id=\"pgc-19822-1-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-1-0-0\" class=\"so-panel widget widget_saleforce-form-theme-widget panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-saleforce-form-theme-widget so-widget-saleforce-form-theme-widget-default-d75171398898-19822\">    <div class=\"modal fade modal-sf-form\" id=\"sf_form_popup\" tabindex=\"-1\" aria-labelledby=\"sf_form_popup\" aria-hidden=\"true\">\n        <div class=\"modal-dialog modal-dialog-scrollable modal-dialog-centered\">\n            <div class=\"modal-content\">\n                <div class=\"modal-body\">\n                    <button type=\"button\" class=\"close\" data-dismiss=\"modal\" aria-label=\"Close\">\n                        <span aria-hidden=\"true\"><\/span>\n                    <\/button>\n    <div id=\"pl-w37a6259c\" class=\"panel-layout\"><div id=\"pg-w37a6259c-0\" class=\"panel-grid panel-has-style\"><div class=\"headline-group panel-row-style panel-row-style-for-w37a6259c-0\"><div id=\"pgc-w37a6259c-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w37a6259c-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w37a6259c-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-b8ea6da32558\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tPlease fill out the form \t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-w37a6259c-0-0-1\" class=\"so-panel widget widget_sow-headline panel-last-child\" data-index=\"1\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w37a6259c-0-0-1\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-3ac3da29e399\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tRegister for the webinar\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-w37a6259c-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w37a6259c-1\"><div id=\"pgc-w37a6259c-1-0\" class=\"panel-grid-cell\"><div id=\"panel-w37a6259c-1-0-0\" class=\"widget_text so-panel widget widget_custom_html panel-first-child panel-last-child\" data-index=\"2\"><div class=\"widget_text panel-widget-style panel-widget-style-for-w37a6259c-1-0-0\"><div class=\"textwidget custom-html-widget\"><script>\njQuery(function($){\n\tvar url = window.location.href;\n\t$('input[name=\"retURL\"]').val(url + '?callaction=toggle-thankyou');\n});\n<\/script>\n\n<style>\n.salesforce-form {\n    background-color: #ffffff;\n    padding: 30px;\n}\n\n#thankyou_popup .modal-content {\n    background-color: #ffffff !important;\n}\n\n#thankyou_popup .modal-body {\n    padding: 60px !important;\n}\n<\/style>\n\n<div class=\"salesforce-form\">\n<!--  ----------------------------------------------------------------------  -->\n<!--  NOTE: Please add the following <META> element to your page <HEAD>.      -->\n<!--  If necessary, please modify the charset parameter to specify the        -->\n<!--  character set of your HTML page.                                        -->\n<!--  ----------------------------------------------------------------------  -->\n<meta http-equiv=\"Content-type\" content=\"text\/html; 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value=\"Somalia\">Somalia<\/option>\n\t\t\t<option value=\"South Africa\">South Africa<\/option>\n\t\t\t<option value=\"South Korea\">South Korea<\/option>\n\t\t\t<option value=\"South Sudan\">South Sudan<\/option>\n\t\t\t<option value=\"Spain\">Spain<\/option>\n\t\t\t<option value=\"Sri Lanka\">Sri Lanka<\/option>\n\t\t\t<option value=\"Sudan\">Sudan<\/option>\n\t\t\t<option value=\"Suriname\">Suriname<\/option>\n\t\t\t<option value=\"Sweden\">Sweden<\/option>\n\t\t\t<option value=\"Switzerland\">Switzerland<\/option>\n\t\t\t<option value=\"Syria\">Syria<\/option>\n\t\t\t<option value=\"Taiwan\">Taiwan<\/option>\n\t\t\t<option value=\"Tajikistan\">Tajikistan<\/option>\n\t\t\t<option value=\"Tanzania\">Tanzania<\/option>\n\t\t\t<option value=\"Thailand\">Thailand<\/option>\n\t\t\t<option value=\"Timor-Leste\">Timor-Leste<\/option>\n\t\t\t<option value=\"Togo\">Togo<\/option>\n\t\t\t<option value=\"Tonga\">Tonga<\/option>\n\t\t\t<option value=\"Trinidad and Tobago\">Trinidad and 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so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p class=\"isSelectedEnd\">We\u2019ve received your details and will send you more information about the webinar shortly.<\/p>\n<p>If you have any questions in the meantime, feel free to get in touch with our team.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-w37a6259c-2\" class=\"panel-grid panel-has-style\"><div class=\"button-group panel-row-style panel-row-style-for-w37a6259c-2\"><div id=\"pgc-w37a6259c-2-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-w37a6259c-2-0\"><div id=\"panel-w37a6259c-2-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-w37a6259c-2-0-0\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"mailto:team.marketing@nanion.de\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tContact us\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><div id=\"pg-19822-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19822-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-19822-3\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19822-3-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Agenda<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19822-3-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<ul>\n<li><strong>Introduction<\/strong><\/li>\n<li><strong><\/strong><strong>Professor Francesco Tadini <\/strong><strong>Buoninsegni <\/strong>(University of Florence) - <em>Investigating sarcoplasmic reticulum Ca<sup>2+<\/sup>-ATPase on solid supported membranes: from mechanistic insights to drug interactions<\/em><\/li>\n<li><strong>Discussion<\/strong> (Q&amp;A session)<\/li>\n<li><strong>Closing words<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-19822-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19822-4\"><div id=\"pgc-19822-4-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-4-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"5\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Who should attend?<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19822-4-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>This webinar is relevant for researchers working in:<\/p>\n<ul>\n<li>Membrane transport and transporter proteins<\/li>\n<li>Calcium signaling and homeostasis<\/li>\n<li>P-type ATPases<\/li>\n<li>Membrane protein pharmacology<\/li>\n<li>SSM-based electrophysiology<\/li>\n<li>Drug discovery and assay development<\/li>\n<\/ul>\n<p data-pm-slice=\"1 1 []\">\ud83d\udc49 Register to join the live presentation and Q&amp;A session.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-19822-4-0-2\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-19822\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/webinar-registration-2\/\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tRegister for the webinar\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-19822-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19822-5\"><div id=\"pgc-19822-5-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-5-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Talk abstracts<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19822-5-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"9\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Investigating sarcoplasmic reticulum Ca<sup>2+<\/sup>-ATPase on solid supported membranes: from mechanistic insights to drug interactions<\/p>\n<p data-start=\"1167\" data-end=\"1212\"><strong data-start=\"1167\" data-end=\"1179\">Speaker:&nbsp;<\/strong>Francesco Tadini Buoninsegni , University of Florence<\/p>\n<p>The sarco(endo)plasmic reticulum Ca<sup>2+<\/sup>-ATPase (SERCA) belongs to the P-type ATPase family of membrane transport proteins. SERCA, which is found in the sarcoplasmic reticulum (SR) of muscle cells, couples ATP hydrolysis to the transport of two Ca<sup>2+<\/sup> ions against their electrochemical potential gradient from the cytoplasm to the SR lumen, thus promoting muscle cell relaxation. SERCA maintains a low cytoplasmic Ca<sup>2+<\/sup> concentration and contributes to intracellular calcium homeostasis which is essential for cell signaling and survival. Impaired SERCA function and regulation have been related to several diseases, such as cardiac and skeletal muscle diseases, neurodegenerative disorders, diabetes and cancer.<\/p>\n<p>We have used an electrophysiological method based on a biomimetic membrane, the so-called solid supported membrane (SSM), to unravel key features of the SERCA transport mechanism. The SSM method allows label-free direct measurements of charge movements generated by the ATPase following adsorption of the membrane-bound enzyme to the SSM and chemical activation by a substrate concentration jump.<\/p>\n<p>Electrical signals generated by SERCA were measured following Ca<sup>2+<\/sup> and ATP jumps on SR vesicles adsorbed to the SSM. The measured charge movements are attributed to distinct electrogenic reaction steps in the SERCA transport cycle, i.e. binding of Ca<sup>2+<\/sup> ions to the cytoplasmic side of the ATPase, and translocation and release of Ca<sup>2+<\/sup> at the luminal side of the enzyme.<\/p>\n<p>Because of its prominent role in intracellular calcium homeostasis and signaling, SERCA represents an attractive target for a variety of drugs. The effects of pharmacologically relevant compounds on the Ca<sup>2+<\/sup> transport activity of SERCA were characterized using the SSM method. We found that these compounds affect calcium transport by SERCA and behave like inhibitors or activators of the enzyme. The molecular mechanism of action of a few selected drugs is discussed.<\/p>\n<p>Finally, SSM-based electrophysiology has also been used to study other prominent members of the P-type ATPase family. In particular, we briefly discuss how the SSM method has contributed to investigating crucial aspects of the transport mechanism of a mammalian copper ATPase and a phospholipid flippase.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-19822-6\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19822-6\"><div id=\"pgc-19822-6-0\" class=\"panel-grid-cell\"><div id=\"panel-19822-6-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"10\"><a href=\"https:\/\/nanion.com\/news\/webinar-series-beyond-the-plasma-membrane\/\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png\" class=\"image wp-image-19828  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-2048x1192.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\"><\/noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-19828  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E 2560w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-2048x1192.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITE-thumbanil-Beyond-the-plasma-memrbane-webinar-series-scaled.png\"><\/a><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Date: November 18, 2026<br \/>\nTime: 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n","protected":false},"featured_media":19831,"template":"","news_categories":[528,13],"class_list":["post-19822","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-event"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/19822","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/19831"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=19822"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=19822"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}