{"id":19511,"date":"2026-05-26T12:28:33","date_gmt":"2026-05-26T10:28:33","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=19511"},"modified":"2026-05-26T14:13:59","modified_gmt":"2026-05-26T12:13:59","slug":"gating-pore-channelopathies","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/gating-pore-channelopathies\/","title":{"rendered":"Gating pore channelopathies"},"content":{"rendered":"<div id=\"pl-19511\" class=\"panel-layout\"><div id=\"pg-19511-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19511-0-0\" class=\"panel-grid-cell\"><div id=\"panel-19511-0-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p data-start=\"226\" data-end=\"693\"><em>In this latest blog, Marc Rogers explores gating pore channelopathies, highlighting how mutations in ion channel voltage sensor gating charges can produce \u201cgating pore\u201d currents linked to human diseases in muscle and neuronal cells.<\/em><\/p>\n<hr>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-19511-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19511-1-0\" class=\"panel-grid-cell\"><div id=\"panel-19511-1-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"1\"><noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\" class=\"image wp-image-14153  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-14153  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E 500w\" sizes=\"(max-width: 500px) 100vw, 500px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\"><\/div><\/div><div id=\"pgc-19511-1-1\" class=\"panel-grid-cell\"><div id=\"panel-19511-1-1-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"2\">\t\t\t<div class=\"textwidget\"><p>After academic research as a neuroscientist and 20 years of commercial ion channel drug discovery, <strong>Marc Rogers<\/strong> now works as a freelance blogger, advisor and consultant for clients in the UK, EU and US where he shares his expertise and enthusiasm for all aspects of ion channel screening. He is particularly interested in automated patch clamp, and exploiting the potential of human iPS stem cell assays to facilitate the successful translation of new drugs into the clinic.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-19511-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19511-2-0\" class=\"panel-grid-cell\"><div id=\"panel-19511-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p data-start=\"769\" data-end=\"916\">The blog reviews the biophysical basis of gating pore currents and how mutations in voltage sensor domains can disrupt normal ion channel function.<\/p>\n<p data-start=\"918\" data-end=\"1244\">The article highlights how S4 helix mutations in channels such as Na<sub>V<\/sub>1.4, Ca<sub>V<\/sub>1.1, Na<sub>V<\/sub>1.5, TRPM7, Ca<sub>V<\/sub>1.3, Ca<sub>V<\/sub>1.4, K<sub>V<\/sub>7.2\/7.3, and Na<sub>V<\/sub>1.2 contribute to diseases including periodic paralysis, dilated cardiomyopathy, trigeminal neuralgia, aldosterone-producing adenomas, congenital stationary night-blindness, epilepsy, and autism.<\/p>\n<p data-start=\"1246\" data-end=\"1447\">Case studies include skeletal muscle myotonias, cardiac myopathy, CNS channelopathies, and recent translational models linking small gating pore currents to altered excitability and disease phenotypes.<\/p>\n<p data-start=\"1449\" data-end=\"1620\">The blog also discusses drug discovery opportunities, including pharmacological inhibition, toxin peptides, VSD-targeting antibodies, and emerging gene therapy approaches.<\/p>\n<p data-start=\"1622\" data-end=\"1894\" data-is-last-node data-is-only-node>Overall, the blog provides a clear and accessible overview of why gating pore currents represent an important and still-developing class of channelopathies, connecting fundamental ion channel biophysics with translational disease models and potential therapeutic strategies.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-19511-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19511-3\"><div id=\"pgc-19511-3-0\" class=\"panel-grid-cell\"><div id=\"panel-19511-3-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-19511\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2026_Nanion-Pre-clinical-Drug-Discovery-Gating-pore-channelopathies.pdf\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tDownload here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-19511-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19511-4\"><div id=\"pgc-19511-4-0\" class=\"panel-grid-cell\"><div id=\"panel-19511-4-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"5\"><a href=\"\/wp-content\/uploads\/2026_Nanion-Pre-clinical-Drug-Discovery-Gating-pore-channelopathies.pdf\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"10000\" height=\"5233\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2.png\" class=\"image wp-image-19517  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2.png 10000w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-300x157.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-1024x536.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-768x402.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-1536x804.png 1536w\" sizes=\"(max-width: 10000px) 100vw, 10000px\"><\/noscript><img decoding=\"async\" width=\"10000\" height=\"5233\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%2010000%205233%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-19517  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%2010000%205233%22%3E%3C%2Fsvg%3E 10000w\" sizes=\"(max-width: 10000px) 100vw, 10000px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2.png 10000w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-300x157.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-1024x536.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-768x402.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2-1536x804.png 1536w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_-Q1-Drug-Discovery-Blog-Marc-Rogers_V2.png\"><\/a><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In this latest blog, Marc Rogers explores gating pore c [&hellip;]<\/p>\n","protected":false},"featured_media":19524,"template":"","news_categories":[528,15],"class_list":["post-19511","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-blogs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/19511","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/19524"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=19511"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=19511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}