{"id":18712,"date":"2025-12-19T12:47:40","date_gmt":"2025-12-19T10:47:40","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=18712"},"modified":"2025-12-19T13:05:36","modified_gmt":"2025-12-19T11:05:36","slug":"renal-channelopathies","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/renal-channelopathies\/","title":{"rendered":"Renal channelopathies"},"content":{"rendered":"<div id=\"pl-18712\" class=\"panel-layout\"><div id=\"pg-18712-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-18712-0-0\" class=\"panel-grid-cell\"><div id=\"panel-18712-0-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p data-start=\"226\" data-end=\"693\"><em>In this latest blog, Marc Rogers explores renal channelopathies, highlighting how disease-causing mutations in kidney ion channels and transporters drive a wide range of inherited and progressive kidney disorders.<\/em><\/p>\n<hr>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-18712-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-18712-1-0\" class=\"panel-grid-cell\"><div id=\"panel-18712-1-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"1\"><noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\" class=\"image wp-image-14153  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-14153  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E 500w\" sizes=\"(max-width: 500px) 100vw, 500px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\"><\/div><\/div><div id=\"pgc-18712-1-1\" class=\"panel-grid-cell\"><div id=\"panel-18712-1-1-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"2\">\t\t\t<div class=\"textwidget\"><p>After academic research as a neuroscientist and 20 years of commercial ion channel drug discovery, <strong>Marc Rogers<\/strong> now works as a freelance blogger, advisor and consultant for clients in the UK, EU and US where he shares his expertise and enthusiasm for all aspects of ion channel screening. He is particularly interested in automated patch clamp, and exploiting the potential of human iPS stem cell assays to facilitate the successful translation of new drugs into the clinic.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-18712-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-18712-2-0\" class=\"panel-grid-cell\"><div id=\"panel-18712-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p data-start=\"0\" data-end=\"382\">The blog reviews the growing recognition of renal ion channels as drug discovery targets, alongside recent progress in genetics, physiology, and translational models.<\/p>\n<p data-start=\"384\" data-end=\"763\">The article highlights how altered function of channels such as ROMK, ClC-K\/ClC-5, TRPC\/TRPP, and APOL1 disrupts salt handling, filtration, and cellular signalling in the kidney, leading to diseases including Bartter syndrome, Dent\u2019s disease, FSGS, and polycystic kidney disease. It also discusses how these insights are guiding new therapeutic strategies beyond supportive care.<\/p>\n<p data-start=\"765\" data-end=\"1090\">Case studies include small-molecule inhibitors, potentiators, and correctors, as well as emerging gene and RNA-based approaches such as ASOs, siRNA delivery, and viral gene therapies. The role of modern screening tools, including automated patch clamp and human iPSC models, is also explored.<\/p>\n<p data-start=\"1092\" data-end=\"1343\" data-is-last-node data-is-only-node>Overall, the blog provides a clear and accessible overview of why renal ion channels represent an underexplored but highly promising area for kidney drug discovery, and how advances in technology are helping to move these targets closer to the clinic.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-18712-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-18712-3\"><div id=\"pgc-18712-3-0\" class=\"panel-grid-cell\"><div id=\"panel-18712-3-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-18712\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies.pdf\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tDownload here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-18712-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-18712-4\"><div id=\"pgc-18712-4-0\" class=\"panel-grid-cell\"><div id=\"panel-18712-4-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"5\"><a href=\"\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies.pdf\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL.png\" class=\"image wp-image-18708  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-2048x1192.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\"><\/noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-18708  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E 2560w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL-2048x1192.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2025_Nanion_Q4_-Drug-Discovery-blog-Renal-channelopathies_WEBSITE-THUMBNAIL.png\"><\/a><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In this latest blog, Marc Rogers explores renal channel [&hellip;]<\/p>\n","protected":false},"featured_media":18708,"template":"","news_categories":[528,15],"class_list":["post-18712","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-blogs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/18712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/18708"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=18712"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=18712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}