{"id":17578,"date":"2025-06-11T08:21:32","date_gmt":"2025-06-11T08:21:32","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=17578"},"modified":"2025-06-11T08:21:32","modified_gmt":"2025-06-11T08:21:32","slug":"ion-channel-gene-therapies","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/ion-channel-gene-therapies\/","title":{"rendered":"Ion channel gene therapies"},"content":{"rendered":"<div id=\"pl-17578\" class=\"panel-layout\"><div id=\"pg-17578-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-17578-0-0\" class=\"panel-grid-cell\"><div id=\"panel-17578-0-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p data-start=\"226\" data-end=\"693\"><em>In this latest blog, Marc Rogers reviews the current status and future potential of ion channel gene therapies \u2014 from gene replacement and editing to RNA-based methods that modulate channel expression. These approaches are now being applied to a broad range of therapeutic areas including pain, epilepsy, cystic fibrosis, and retinal diseases.<\/em><\/p>\n<hr>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-17578-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-17578-1-0\" class=\"panel-grid-cell\"><div id=\"panel-17578-1-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"1\"><noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\" class=\"image wp-image-14153  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-14153  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E 500w\" sizes=\"(max-width: 500px) 100vw, 500px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\"><\/div><\/div><div id=\"pgc-17578-1-1\" class=\"panel-grid-cell\"><div id=\"panel-17578-1-1-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"2\">\t\t\t<div class=\"textwidget\"><p>After academic research as a neuroscientist and 20 years of commercial ion channel drug discovery, <strong>Marc Rogers<\/strong> now works as a freelance blogger, advisor and consultant for clients in the UK, EU and US where he shares his expertise and enthusiasm for all aspects of ion channel screening. He is particularly interested in automated patch clamp, and exploiting the potential of human iPS stem cell assays to facilitate the successful translation of new drugs into the clinic.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-17578-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-17578-2-0\" class=\"panel-grid-cell\"><div id=\"panel-17578-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr>\n<p data-start=\"709\" data-end=\"949\">The blog highlights how these genetic techniques are being used to correct mutations, regulate gene expression, or reduce disease-driving ion channel activity, often with greater selectivity and duration than traditional small molecules.<\/p>\n<p data-start=\"951\" data-end=\"1279\">Case studies include programs targeting <strong data-start=\"991\" data-end=\"1001\">Na<sub>v<\/sub>1.7<\/strong>, <strong data-start=\"1003\" data-end=\"1013\">Na<sub>v<\/sub>1.1<\/strong>, <strong data-start=\"1015\" data-end=\"1025\">Na<sub>v<\/sub>1.2<\/strong>, <strong data-start=\"1027\" data-end=\"1036\">K<sub>v<\/sub>1.1<\/strong>, <strong data-start=\"1038\" data-end=\"1046\">CFTR<\/strong>, and <strong data-start=\"1052\" data-end=\"1062\">Kir7.1<\/strong>, using tools such as AAV vectors, ASOs, RNAi, CRISPR, and epigenetic modifiers. The role of delivery vectors, safety challenges, and functional readouts (e.g. automated patch clamp, iPSC models) are also discussed.<\/p>\n<p data-start=\"1281\" data-end=\"1445\">This blog offers a detailed but accessible overview of how gene therapy is being integrated into ion channel drug discovery, and where the field may be headed next.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-17578-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-17578-3\"><div id=\"pgc-17578-3-0\" class=\"panel-grid-cell\"><div id=\"panel-17578-3-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-17578\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/content-download\/\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tDownload here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-17578-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-17578-4\"><div id=\"pgc-17578-4-0\" class=\"panel-grid-cell\"><div id=\"panel-17578-4-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"5\"><a href=\"\/content-download\/\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-scaled.png\" class=\"image wp-image-17582  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-2048x1192.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\"><\/noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-17582  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E 2560w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-2048x1192.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2025\/06\/20250611_preclinical-drug-discovery-blog-Q1-Ion-channel-gene-therapy-Marc-Rogers-WEBSITE-THUMBNAIL-scaled.png\"><\/a><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In this latest blog, Marc Rogers reviews the current st [&hellip;]<\/p>\n","protected":false},"featured_media":17582,"template":"","news_categories":[528,15],"class_list":["post-17578","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-blogs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/17578","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/17582"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=17578"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=17578"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}