{"id":16709,"date":"2024-12-18T14:36:26","date_gmt":"2024-12-18T14:36:26","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=16709"},"modified":"2025-03-04T07:46:03","modified_gmt":"2025-03-04T07:46:03","slug":"antibodies-as-ion-channel-modulators-and-drugs","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/antibodies-as-ion-channel-modulators-and-drugs\/","title":{"rendered":"Antibodies as ion channel modulators and drugs"},"content":{"rendered":"<div id=\"pl-16709\" class=\"panel-layout\"><div id=\"pg-16709-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-16709-0-0\" class=\"panel-grid-cell\"><div id=\"panel-16709-0-0-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p><em>In his third preclinical ion channel drug discovery blog, Marc Rogers explores the evolution of antibodies as ion channel modulators, highlighting breakthroughs in monoclonal antibodies, nanobodies, and antibody-toxin chimeras across immunology, cardiology, neuroscience, and oncology. Key case studies include Kv, Nav, Cav, TRP channels, and GPCR targets revealed through manual and automated patch clamp technologies\u200b.<\/em><\/p>\n<hr>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-16709-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-16709-1-0\" class=\"panel-grid-cell\"><div id=\"panel-16709-1-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"1\"><noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\" class=\"image wp-image-14153  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" sizes=\"(max-width: 500px) 100vw, 500px\"><\/noscript><img decoding=\"async\" width=\"500\" height=\"500\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-14153  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20500%20500%22%3E%3C%2Fsvg%3E 500w\" sizes=\"(max-width: 500px) 100vw, 500px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png 500w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-300x300.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green-150x150.png 150w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/04\/Marc-Rogers_accent-green.png\"><\/div><\/div><div id=\"pgc-16709-1-1\" class=\"panel-grid-cell\"><div id=\"panel-16709-1-1-0\" class=\"so-panel widget widget_text panel-first-child panel-last-child\" data-index=\"2\">\t\t\t<div class=\"textwidget\"><p>After academic research as a neuroscientist and 20 years of commercial ion channel drug discovery, <strong>Marc Rogers<\/strong> now works as a freelance blogger, advisor and consultant for clients in the UK, EU and US where he shares his expertise and enthusiasm for all aspects of ion channel screening. He is particularly interested in automated patch clamp, and exploiting the potential of human iPS stem cell assays to facilitate the successful translation of new drugs into the clinic.<\/p>\n<\/div>\n\t\t<\/div><\/div><\/div><div id=\"pg-16709-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-16709-2-0\" class=\"panel-grid-cell\"><div id=\"panel-16709-2-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr>\n<p>&nbsp;<\/p>\n<p>With the ongoing shift in clinical therapeutics from small molecules to biologics, now is the perfect time to dive into the evolution and current status of antibody ligands as ion channel modulators. This comprehensive review examines efforts in academia and industry to develop polyclonal and monoclonal antibodies, single-domain nanobodies, and antibody-toxin chimeras. These innovations are advancing preclinical research in immunology, cardiology, neuroscience, and oncology.<\/p>\n<p>Highlights include case studies on antibodies targeting K<sub>v<\/sub>, K<sub>Ca<\/sub>, K2P, Kir, Na<sub>v<\/sub>1.x, Ca<sub>v<\/sub>, TRPx, P2X, ASIC, and Orai channels. Functional insights from manual and automated patch clamp (APC) electrophysiology showcase their potential. Building on over 25 years of research, this blog offers a fresh update with the latest publications and commercial developments.<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-16709-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-16709-3\"><div id=\"pgc-16709-3-0\" class=\"panel-grid-cell\"><div id=\"panel-16709-3-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-16709\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2024\/12\/2024_Nanion_Q4_Preclinical-Drug-Discovery-Blog_Antibodies-as-ion-channel-modulators-and-drugs.pdf\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tDownload here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-16709-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-16709-4\"><div id=\"pgc-16709-4-0\" class=\"panel-grid-cell\"><div id=\"panel-16709-4-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"5\"><a href=\"\/wp-content\/uploads\/2024\/12\/2024_Nanion_Q4_Preclinical-Drug-Discovery-Blog_Antibodies-as-ion-channel-modulators-and-drugs.pdf\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"1625\" height=\"946\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail.png\" class=\"image wp-image-16716  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail.png 1625w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-1536x894.png 1536w\" sizes=\"(max-width: 1625px) 100vw, 1625px\"><\/noscript><img decoding=\"async\" width=\"1625\" height=\"946\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201625%20946%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-16716  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201625%20946%22%3E%3C%2Fsvg%3E 1625w\" sizes=\"(max-width: 1625px) 100vw, 1625px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail.png 1625w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail-1536x894.png 1536w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/12\/20241218_Mar-rogers-blog-Q4_Thumbnail.png\"><\/a><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>In his third preclinical ion channel drug discovery blo [&hellip;]<\/p>\n","protected":false},"featured_media":16716,"template":"","news_categories":[528,15],"class_list":["post-16709","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-blogs"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/16709","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/16716"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=16709"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=16709"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}