{"id":14457,"date":"2024-05-23T07:21:35","date_gmt":"2024-05-23T07:21:35","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=news&#038;p=14457"},"modified":"2024-05-28T07:23:36","modified_gmt":"2024-05-28T07:23:36","slug":"trace-level-cytokines-and-cardiovascular-profiling-for-long-term-covid-diagnostic","status":"publish","type":"news","link":"https:\/\/nanion.com\/zh-hans\/news\/trace-level-cytokines-and-cardiovascular-profiling-for-long-term-covid-diagnostic\/","title":{"rendered":"Trace-level cytokines and cardiovascular profiling for long-term COVID diagnostic"},"content":{"rendered":"<div id=\"pl-14457\" class=\"panel-layout\"><div id=\"pg-14457-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14457-0-0\" class=\"panel-grid-cell\"><div id=\"panel-14457-0-0-0\" class=\"so-panel widget widget_text panel-first-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p><strong>When:<\/strong> 27.06.2024, 16:00 \u2013 17:00 h CEST (8:00 &#8211; 9:00 h MDT)<\/p>\n<p><strong>Venue<\/strong>: online<\/p>\n<\/div>\n\t\t<\/div><div id=\"panel-14457-0-0-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"1\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-14457\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"https:\/\/www.labroots.com\/ms\/webinar\/trace-level-cytokines-cardiovascular-profiling-long-term-covid-diagnostic\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tRegister here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14457-1\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14457-1-0\" class=\"panel-grid-cell\"><div id=\"panel-14457-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<hr>\n<h4><noscript><img decoding=\"async\" class=\"alignnone size-full wp-image-14460\" src=\"\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots.png\" alt width=\"926\" height=\"185\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots.png 926w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots-300x60.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots-768x153.png 768w\" sizes=\"(max-width: 926px) 100vw, 926px\"><\/noscript><img decoding=\"async\" class=\"alignnone size-full wp-image-14460 lazyload\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20926%20185%22%3E%3C%2Fsvg%3E\" alt width=\"926\" height=\"185\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%20926%20185%22%3E%3C%2Fsvg%3E 926w\" sizes=\"(max-width: 926px) 100vw, 926px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots.png 926w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots-300x60.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots-768x153.png 768w\" data-src=\"\/wp-content\/uploads\/2024\/05\/926x185-1-provided-by-labroots.png\"><\/h4>\n<h4><\/h4>\n<h4><\/h4>\n<h4><\/h4>\n<h4><strong><span style=\"color: #000000;\">Summary of the Webinar<\/span><\/strong><\/h4>\n<p>&nbsp;<\/p>\n<p>Globally, over 65 million individuals are estimated to suffer from post-acute sequelae of COVID-19 (PASC). A large number of individuals living with PASC experience cardiovascular symptoms (i.e. chest pain and heart palpitations) (PASC-CVS). The role of chronic inflammation in these symptoms, in particular in individuals with symptoms persisting for &gt;1 year after SARS-CoV-2 infection, remains to be clearly defined. In this cross-sectional study, blood samples were obtained from three different sites in Australia from individuals with i) a resolved SARS-CoV-2 infection (and no persistent symptoms i.e. \u2018Recovered\u2019), ii) individuals with prolonged PASC-CVS and iii) SARS-CoV-2 negative individuals. Individuals with PASC-CVS, relative to Recovered individuals, had a blood transcriptomic signature associated with inflammation. This was accompanied by elevated levels of pro-inflammatory cytokines (IL-12, IL-1\u03b2, MCP-1 and IL-6) at approximately 18 months post-infection. These cytokines were present in trace amounts, such that they could only be detected with the use of novel nanotechnology. Importantly, these trace-level cytokines had a direct effect on the functionality of pluripotent stem cell derived cardiomyocytes in vitro. This effect was not observed in the presence of dexamethasone. Plasma proteomics demonstrated further differences between PASC-CVS and Recovered patients at approximately 18 months post-infection including enrichment of complement and coagulation associated proteins in those with prolonged cardiovascular symptoms. Together, these data provide a new insight into the role of chronic inflammation in PASC-CVS and present nanotechnology as a possible novel diagnostic approach for the condition.<\/p>\n<p>&nbsp;<\/p>\n<hr>\n<h4><\/h4>\n<h4><strong>Webinar Agenda:<\/strong><\/h4>\n<ol>\n<li>Introduction\n<ul>\n<li><strong>Sonja-Stoelzle-Feix<\/strong> (Director of Scientific Affairs, Nanion Technologies)<\/li>\n<\/ul>\n<\/li>\n<li>\u201cCardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes\u201d\n<ul>\n<li><strong>Kirsty Short<\/strong> (Associate Professor, University of Queensland)<\/li>\n<\/ul>\n<\/li>\n<li>Discussion<\/li>\n<\/ol>\n<\/div>\n<\/div><\/div><div id=\"panel-14457-1-0-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"3\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-14457\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"https:\/\/www.labroots.com\/ms\/webinar\/trace-level-cytokines-cardiovascular-profiling-long-term-covid-diagnostic\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tRegister here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14457-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14457-2-0\" class=\"panel-grid-cell\"><div id=\"panel-14457-2-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"4\"><a href=\"https:\/\/www.labroots.com\/ms\/webinar\/trace-level-cytokines-cardiovascular-profiling-long-term-covid-diagnostic\" target=\"_blank\"><noscript><img decoding=\"async\" width=\"1625\" height=\"946\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website.png\" class=\"image wp-image-14467  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website.png 1625w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-1536x894.png 1536w\" sizes=\"(max-width: 1625px) 100vw, 1625px\"><\/noscript><img decoding=\"async\" width=\"1625\" height=\"946\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201625%20946%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-14467  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201625%20946%22%3E%3C%2Fsvg%3E 1625w\" sizes=\"(max-width: 1625px) 100vw, 1625px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website.png 1625w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website-1536x894.png 1536w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2024\/05\/2024_06_COVID-Webinar-Thumbnail-for-Website.png\"><\/a><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>When: 27.06.2024, 16:00 \u2013 17:00 h CEST (8:00 &#8211; 9:00 h M [&hellip;]<\/p>\n","protected":false},"featured_media":14467,"template":"","news_categories":[528,13],"class_list":["post-14457","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-event"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news\/14457","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media\/14467"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/media?parent=14457"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/zh-hans\/wp-json\/wp\/v2\/news_categories?post=14457"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}