{"id":7147,"date":"2023-02-17T07:00:19","date_gmt":"2023-02-17T07:00:19","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/28-04-2020-webinar-validation-and-optimization-of-automated-patch-clamp-voltage-gated-ca2-channel-assays\/"},"modified":"2023-02-17T07:00:19","modified_gmt":"2023-02-17T07:00:19","slug":"28-04-2020-webinar-validation-and-optimization-of-automated-patch-clamp-voltage-gated-ca2-channel-assays","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/28-04-2020-webinar-validation-and-optimization-of-automated-patch-clamp-voltage-gated-ca2-channel-assays\/","title":{"rendered":"28.04.2020 | Webinar: Validation and optimization of automated patch clamp voltage-gated Ca<sup>2+<\/sup> channel assays"},"content":{"rendered":"<p>Marc will outline the development, optimization and validation of a range of voltage-gated Ca<sup>2+<\/sup> channel assays on the Patchliner automated patch clamp platform that were subsequently used in an 8 year drug discovery collaboration between Metrion Biosciences and a german pharma company.<\/p>\n<p>The project was successful in identifying several lead series of selective,state-dependent inhibitors of Cav2.2 N-type channels for use as novel, non-opioid analgesic.This required the creation of biophysical screening assays to identify the potency of small molecules against the resting and inactivated state of the human neuronal Ca<sup>2+<\/sup> channels Cav2.1(P\/Q type), Cav2.2 and Cav3.2 (T-type), some of which are notoriously difficult in terms of expression levels and current rundown.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[320],"application_areas":[50,53],"therapeutic_areas":[],"target_categories":[61,337,335,338],"target_families":[332,339,340,354,358],"targets":[101,106,107,114,116,119,250],"resource_keyword":[],"class_list":["post-7147","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-webinar","application_areas-ion-channels","application_areas-assay-development-and-validation","target_categories-voltage-gated-ion-channels","target_categories-ligand-gated-ion-channels","target_categories-intracellular-regulated-ion-channels","target_categories-other-ion-channels","target_families-nav-channels","target_families-trp-channels","target_families-cav-channels","target_families-calcium-and-sodium-activated-potassium-channels-kca-and-kna","target_families-p2x-receptors","targets-trpv1","targets-cav2-2","targets-cav3-2","targets-kca3-1","targets-nav1-7","targets-p2x3","targets-cav2-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/7147","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=7147"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=7147"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=7147"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=7147"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=7147"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=7147"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=7147"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=7147"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=7147"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}