{"id":7108,"date":"2023-02-17T07:05:56","date_gmt":"2023-02-17T07:05:56","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/07-09-2021-webinar-automated-patch-clamp-assay-development-for-the-study-of-red-blood-cells-rbcs-in-health-and-disease\/"},"modified":"2023-02-17T07:05:56","modified_gmt":"2023-02-17T07:05:56","slug":"07-09-2021-webinar-automated-patch-clamp-assay-development-for-the-study-of-red-blood-cells-rbcs-in-health-and-disease","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/07-09-2021-webinar-automated-patch-clamp-assay-development-for-the-study-of-red-blood-cells-rbcs-in-health-and-disease\/","title":{"rendered":"07.09.2021 | Webinar: Automated patch clamp assay development for the study of red blood cells (RBCs) in health and disease"},"content":{"rendered":"<p>Calcium (Ca<sup>2+<\/sup>) is a universal signalling molecule and is critically important in regulating many physiological functions and survival of RBCs. Amongst others, intracellular Ca<sup>2+<\/sup> controls cell volume and deformability. This process plays a substantial role in RBCs since their volume needs to adapt when passing blood vessel constrictions during the flow. Excessive Ca<sup>2+<\/sup> uptake also leads to accelerated cell clearance causing anaemia.<\/p>\n<p>Therefore, studying Ca<sup>2+<\/sup> regulation is crucial to understand RBC diseases. Piezo1, KCa3.1 (Gardos channel) and NMDA receptors are three channels present in the RBC membrane and critical for Ca<sup>2+<\/sup> regulation.<\/p>\n<p>We developed functional assays to measure these channels in healthy and diseased RBCs populations using electrophysiological tools, contributing to the characterization of RBC diseases.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[42,44,45],"resource_type":[320],"application_areas":[50,53,76],"therapeutic_areas":[],"target_categories":[61,335,338],"target_families":[340,354,365],"targets":[114,120,250],"resource_keyword":[],"class_list":["post-7108","resource_library","type-resource_library","status-publish","hentry","products_tags-syncropatch-384","products_tags-patchliner","products_tags-port-a-patch","resource_type-webinar","application_areas-ion-channels","application_areas-assay-development-and-validation","application_areas-drug-discovery","target_categories-voltage-gated-ion-channels","target_categories-intracellular-regulated-ion-channels","target_categories-other-ion-channels","target_families-cav-channels","target_families-calcium-and-sodium-activated-potassium-channels-kca-and-kna","target_families-piezo-channels","targets-kca3-1","targets-piezo1","targets-cav2-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/7108","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=7108"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=7108"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=7108"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=7108"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=7108"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=7108"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=7108"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=7108"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=7108"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}