{"id":6806,"date":"2023-02-17T07:05:16","date_gmt":"2023-02-17T07:05:16","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/trpm7-trpm7-activation-by-internal-sequestering-of-mg2-ions-recorded-on-the-port-a-patch\/"},"modified":"2023-02-17T07:05:18","modified_gmt":"2023-02-17T07:05:18","slug":"trpm7-trpm7-activation-by-internal-sequestering-of-mg2-ions-recorded-on-the-port-a-patch","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/trpm7-trpm7-activation-by-internal-sequestering-of-mg2-ions-recorded-on-the-port-a-patch\/","title":{"rendered":"TRPM7 &#8211; &#8220;TRPM7 activation by internal sequestering of Mg<sup>2+<\/sup> ions recorded on the Port-a-Patch&#8221;"},"content":{"rendered":"<p>Transient receptor potential (TRP) channels are an\u00a0important class of receptors found widely distributed\u00a0throughout the mammalian central and peripheral\u00a0nervous systems. They have been shown to be\u00a0activated by many stimuli including temperature,\u00a0mechano-stimulation, divalent cations and pH, amongst\u00a0others. TRP channels are receiving much attention as\u00a0potential targets for the treatment of, for example, pain,\u00a0respiratory diseases such as asthma, cancer and immune\u00a0disorders.\u00a0The TRPM7 receptor is thought to play a role in\u00a0magnesium homeostasis. A role for TRPM7 in intracellular\u00a0pH sensing, the pathological response to blood\u00a0vessel wall injury\u00a0and cell adhesion has also been\u00a0suggested. In electrophysiological studies TRPM7 can\u00a0be recorded using a voltage ramp protocol. It displays\u00a0a characteristic large outward current with little inward\u00a0current and can be blocked by the presence of internal\u00a0Mg<sup>2+<\/sup>\u00a0ions.\u00a0Here we present data recorded on the Port-a-Patch with internal perfusion showing recordings of mouse\u00a0TRPM7 (mTRPM7) and block of this channel by the internal\u00a0perfusion of Mg<sup>2+<\/sup>\u00a0ions.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[],"target_categories":[337,338],"target_families":[339],"targets":[127],"resource_keyword":[],"class_list":["post-6806","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-application-note","application_areas-ion-channels","target_categories-ligand-gated-ion-channels","target_categories-other-ion-channels","target_families-trp-channels","targets-trpm7"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6806","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6806"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6806"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6806"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6806"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6806"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6806"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6806"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6806"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6806"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}