{"id":6804,"date":"2023-02-17T07:05:16","date_gmt":"2023-02-17T07:05:16","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/trpa1-trpa1-activation-by-allyl-isothiocyanate-recorded-on-the-port-a-patch\/"},"modified":"2023-02-17T07:05:16","modified_gmt":"2023-02-17T07:05:16","slug":"trpa1-trpa1-activation-by-allyl-isothiocyanate-recorded-on-the-port-a-patch","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/trpa1-trpa1-activation-by-allyl-isothiocyanate-recorded-on-the-port-a-patch\/","title":{"rendered":"TRPA1 &#8211; &#8220;TRPA1 activation by allyl isothiocyanate recorded on the Port-a-Patch&#8221;"},"content":{"rendered":"<p>Transient receptor potential (TRP) channels are an\u00a0important class of receptors found widely distributed\u00a0throughout the mammalian central and peripheral\u00a0nervous systems. They have been shown to be\u00a0activated by many stimuli including temperature,\u00a0mechano-stimulation, divalent cations and pH, amongst\u00a0others. TRP channels are receiving much attention as\u00a0potential targets for the treatment of, for example, pain,\u00a0respiratory diseases such as asthma, cancer and immune\u00a0disorders (for review see ref. 1).\u00a0The TRPA1 receptor was first cloned from cultured\u00a0human lung fibroblasts but has subsequently been found\u00a0to be expressed in sensory neurones and is often found\u00a0co-localised with TRPV1. TRPA1 is\u00a0activated by a number of chemical stimuli including\u00a0allyl isothiocyanate (mustard oil), cinnamaldehyde (the\u00a0active ingredient of cinnamon), chlorobenzylidene\u00a0malononitrile (CS tear gas), hydrogen peroxide and\u00a0hyperchlorite (chlorine gas). It is thought that TRPA1,\u00a0together with TRPV1, may contribute to chemical\u00a0hypersensitivity, chronic cough, and airway inflammation\u00a0in asthma.\u00a0Here we present data recorded on the Port-aPatch\u00a0with external perfusion showing recordings of\u00a0human TRPA1 (hTRPA1) activated by increasing\u00a0concentrations of allyl isothiocyanate (AITC). hTRPA1\u00a0could be repetitively stimulated using low concentrations\u00a0of AITC but was desensitized by high concentrations of\u00a0AITC (>10 \u00b5M).<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55,56],"target_categories":[337,338],"target_families":[339],"targets":[126],"resource_keyword":[],"class_list":["post-6804","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","therapeutic_areas-pain","target_categories-ligand-gated-ion-channels","target_categories-other-ion-channels","target_families-trp-channels","targets-trpa1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6804","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6804"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6804"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6804"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6804"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6804"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6804"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6804"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6804"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6804"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}