{"id":6792,"date":"2023-02-17T07:04:57","date_gmt":"2023-02-17T07:04:57","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/herg-pharmacology-of-herg-recorded-on-nanions-port-a-patch\/"},"modified":"2023-02-17T07:04:57","modified_gmt":"2023-02-17T07:04:57","slug":"herg-pharmacology-of-herg-recorded-on-nanions-port-a-patch","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/herg-pharmacology-of-herg-recorded-on-nanions-port-a-patch\/","title":{"rendered":"hERG &#8211; &#8220;Pharmacology of hERG recorded on Nanion\u00b4s Port-a-Patch&#8221;"},"content":{"rendered":"<p>The hERG gene (KCNH2) encodes a potassium ion\u00a0channel responsible for the repolarizing I<sup>Kr<\/sup> current in the\u00a0cardiac action potential (Sanguinetti et al., 1995).\u00a0Abnormalities in this channel may lead to either Long QT\u00a0syndrome (LQT2) (with loss-of-function mutations) or Short\u00a0QT syndrome (with gain-of-function mutations), both\u00a0potentially fatal cardiac arrhythmia, due to repolarization\u00a0disturbances of the cardiac action potential.\u00a0Given the importance of this channel in maintaining\u00a0cardiac function, it has become an important target in\u00a0compound safety screening.\u00a0A large range of therapeutic agents with diverse chemical\u00a0structures have been reported to induce long QT\u00a0syndrome. These include antihistamines (e.g. Terfenadine),\u00a0gastrointestinal prokinetic agents (e.g. Cisapride) and\u00a0others.\u00a0Here we present data collected on the Port-a-Patch.\u00a0Astemizole, Terfenadine, Cisapride and Flunarizine\u00a0dose-response curves on hERG expressed in CHO cells\u00a0are shown. The mean current amplitude in these cells was\u00a01076 \u00b1 79 pA (n= 88) at -40 mV.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[54],"target_categories":[61],"target_families":[333],"targets":[92],"resource_keyword":[],"class_list":["post-6792","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cardiac-safety-cipa","target_categories-voltage-gated-ion-channels","target_families-kv-channels","targets-kv11-1-herg"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6792","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6792"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6792"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6792"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6792"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6792"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6792"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6792"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6792"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6792"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}