{"id":6784,"date":"2023-02-17T07:04:45","date_gmt":"2023-02-17T07:04:45","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/cav3-2-characterization-of-cav3-2-on-nanions-port-a-patch\/"},"modified":"2023-02-17T07:04:45","modified_gmt":"2023-02-17T07:04:45","slug":"cav3-2-characterization-of-cav3-2-on-nanions-port-a-patch","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/cav3-2-characterization-of-cav3-2-on-nanions-port-a-patch\/","title":{"rendered":"CaV3.2 &#8211; &#8220;Characterization of CaV3.2 on Nanion&#8217;s Port-a-Patch&#8221;"},"content":{"rendered":"<p>The gene CACNA1H encodes the \u03b11H subunit of the voltage-gated\u00a0calcium channel CaV3.2. It belongs to the low\u00a0voltage-activated T-type calcium channels. CaV3.2 displays\u00a0the typical characteristics of the T-type channels:\u00a0activation at low depolarization of the membrane and\u00a0transient kinetics.\u00a0T-type Ca<sup>2+<\/sup>\u00a0channels are involved in diverse, mainly rhythmic\u00a0processes like e.g. pacemaking and generation of\u00a0thalamocortical rhythms in sleep or epilepsy. CaV3.2 is\u00a0expressed in a wide variety of cells. Amongst others it\u00a0has been found in kidney, smooth muscle, brain, adrenal\u00a0and cardiac cells. It seems to be involved in contraction\u00a0of smooth muscle and the secretion of the adrenal hormones\u00a0aldosterone and cortisol. Pharmacological block\u00a0of T-type channels may lead to new drugs for the treatment\u00a0of hypertension and epilepsy.\u00a0The biophysical and pharmacological properties of the\u00a0cells are presented in this Application Note.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55],"target_categories":[61],"target_families":[340],"targets":[107],"resource_keyword":[],"class_list":["post-6784","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","target_categories-voltage-gated-ion-channels","target_families-cav-channels","targets-cav3-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6784","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6784"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6784"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6784"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6784"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6784"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6784"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6784"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6784"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6784"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}