{"id":6782,"date":"2023-02-17T07:04:39","date_gmt":"2023-02-17T07:04:39","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/cav2-2-characterization-of-cav2-2-on-nanions-port-a-patch\/"},"modified":"2023-02-17T07:04:42","modified_gmt":"2023-02-17T07:04:42","slug":"cav2-2-characterization-of-cav2-2-on-nanions-port-a-patch","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/cav2-2-characterization-of-cav2-2-on-nanions-port-a-patch\/","title":{"rendered":"CaV2.2 &#8211; &#8220;Characterization of CaV2.2 on Nanion&#8217;s Port-a-Patch&#8221;"},"content":{"rendered":"<p>The voltage gated N-type calcium channel (CaV2.2) is\u00a0encoded by the gene CACNA1B. CaV2.2 is a high voltage activated calcium channel.\u00a0CaV2.2 is found mainly in the brain, where it mediates neurotransmitter\u00a0release at the \u00a0synapse. The strong depolarization\u00a0of neuronal action potentials causes the opening\u00a0of the channel. Calcium can then enter the cell and initiates\u00a0the fusion of the neurotransmitter vesicles with the\u00a0membrane.\u00a0CaV2.2 is inhibited by w-conotoxin, a neurotoxin of the fish\u00a0hunting snail, with high specificity. CaV2.2 has been implicated\u00a0in the transmission of pain. Pharmacological block\u00a0of CaV2.2 by compounds based on w-conotoxin has been\u00a0shown to be effective against strong \u00a0chronical pain.\u00a0The biophysical and pharmacological properties of the\u00a0cells are presented in this Application Note.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55,56],"target_categories":[61],"target_families":[340],"targets":[106],"resource_keyword":[],"class_list":["post-6782","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","therapeutic_areas-pain","target_categories-voltage-gated-ion-channels","target_families-cav-channels","targets-cav2-2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6782","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6782"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6782"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6782"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6782"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6782"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6782"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6782"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6782"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6782"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}