{"id":6774,"date":"2023-02-17T06:59:30","date_gmt":"2023-02-17T06:59:30","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/trpv1-heat-activation-of-trpv1-on-nanions-patchliner\/"},"modified":"2023-02-17T06:59:32","modified_gmt":"2023-02-17T06:59:32","slug":"trpv1-heat-activation-of-trpv1-on-nanions-patchliner","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/trpv1-heat-activation-of-trpv1-on-nanions-patchliner\/","title":{"rendered":"TRPV1 &#8211; &#8220;Heat activation of TRPV1 on Nanion&#8217;s Patchliner&#8221;"},"content":{"rendered":"<p>The transient receptor potential cation channel, subfamily\u00a0V, member 1 (TRPV1), is a ligand-gated, non-selective\u00a0cation channel widely expressed in the peripheral\u00a0and central nervous system. The TRPV1 channel can\u00a0be activated by a number of physical and chemical\u00a0stimuli, including capsaicin (the active ingredient in chili\u00a0peppers), noxious heat (typically >42\u02daC) and low pH. The\u00a0TRPV1 channel is putatively involved in the perception\u00a0and transmission of painful stimuli. Importantly, this\u00a0channel is proposed to underlie many chronic pain states\u00a0including inflammation, neuropathic pain and cancer\u00a0pain, amongst others. These types of pain states are\u00a0currently poorly managed by the pain medications\u00a0available and this has led the pharmaceutical industry\u00a0to seek novel targets for pain management, such as\u00a0TRPV1. However, TRPV1 antagonists have so far failed\u00a0in clinical trials due to an undesirable increase in core\u00a0body temperature resulting in hyperthermia. From\u00a0these studies, it is proposed that tonically active TRPV1\u00a0channels are involved in maintaining normal body\u00a0temperature and this could have significant influences\u00a0on drug design. Finding novel compounds with differing\u00a0effects on capsaicin activation and heat activation may\u00a0be crucial in the discovery of lead compounds for the\u00a0treatment of pain and other disease states.\u00a0Here we present data collected on the 4-channel\u00a0Patchliner with temperature control showing the\u00a0potential use of the Patchliner\u00ae to record capsaicin and\u00a0heat activation of TRPV1 channels and subsequent block\u00a0by ruthenium red (RR).<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55,56],"target_categories":[337,338],"target_families":[339],"targets":[101],"resource_keyword":[],"class_list":["post-6774","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","therapeutic_areas-pain","target_categories-ligand-gated-ion-channels","target_categories-other-ion-channels","target_families-trp-channels","targets-trpv1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6774","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6774"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6774"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6774"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6774"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6774"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6774"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6774"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6774"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6774"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}