{"id":6772,"date":"2023-02-17T06:59:30","date_gmt":"2023-02-17T06:59:30","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/trpm8-trpm8-activation-by-menthol-and-eucalyptol-performed-on-nanions-patchliner\/"},"modified":"2023-02-17T06:59:30","modified_gmt":"2023-02-17T06:59:30","slug":"trpm8-trpm8-activation-by-menthol-and-eucalyptol-performed-on-nanions-patchliner","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/trpm8-trpm8-activation-by-menthol-and-eucalyptol-performed-on-nanions-patchliner\/","title":{"rendered":"TRPM8 &#8211; &#8220;TRPM8 activation by menthol and Eucalyptol performed on Nanion\u2019s Patchliner&#8221;"},"content":{"rendered":"<p>TRPM8 is a member of the transient receptor potential\u00a0channel (TRP) family. TRPM8 is known to be a thermosensitive\u00a0channel, activated by cold temperatures\u00a0(below ~25\u02daC) and ligands such as menthol, Eucalyptol\u00a0and icilin. It belongs to the melastatin subfamily of TRP\u00a0channels and shows an outward rectification with a\u00a0relatively high permeability for calcium ions and\u00a0little selectivity between monovalent cations. Menthol,\u00a0a secondary alcohol produced by the peppermint\u00a0herb, Mentha piperita, is widely used in the food and\u00a0pharmaceutical industries as a cooling\/soothing\u00a0compound and odorant. It induces Ca<sup>2+<\/sup>\u00a0influx in a\u00a0subset of sensory neurons from dorsal root and trigeminal\u00a0ganglia, where the TRPM8 channel is specifically\u00a0expressed.\u00a0Here we present data of hTRPM8 collected on the\u00a0Patchliner. Cells performed well on the Patchliner with a success rate of 89% for seal resistance >600 M\u2126.\u00a0Channel activation by the agonists menthol and\u00a0Eucalyptol is shown.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[90],"application_areas":[50],"therapeutic_areas":[55,56],"target_categories":[337,338],"target_families":[339],"targets":[122],"resource_keyword":[],"class_list":["post-6772","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-application-note","application_areas-ion-channels","therapeutic_areas-cns","therapeutic_areas-pain","target_categories-ligand-gated-ion-channels","target_categories-other-ion-channels","target_families-trp-channels","targets-trpm8"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6772","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6772"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6772"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6772"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6772"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6772"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6772"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6772"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6772"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6772"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}