{"id":6533,"date":"2023-02-17T06:57:57","date_gmt":"2023-02-17T06:57:57","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/2021-modeling-of-ion-channels-a-side-by-side-comparison-between-hodgkin-huxley-and-hidden-markov-approach-on-the-example-of-kv1-1\/"},"modified":"2023-02-17T06:57:57","modified_gmt":"2023-02-17T06:57:57","slug":"2021-modeling-of-ion-channels-a-side-by-side-comparison-between-hodgkin-huxley-and-hidden-markov-approach-on-the-example-of-kv1-1","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2021-modeling-of-ion-channels-a-side-by-side-comparison-between-hodgkin-huxley-and-hidden-markov-approach-on-the-example-of-kv1-1\/","title":{"rendered":"2021 &#8211; Modeling of ion channels &#8211; A side by side comparison between Hodgkin Huxley and hidden Markov approach on the example of KV1.1"},"content":{"rendered":"<p>Mathematical models of individual ion\u00a0channels form the building blocks of complex in-silico\u00a0tools, enabling the investigation of biophysical mechanisms and simulation of disease processes. We here\u00a0propose a first simplified hidden Markov Model (HMM)\u00a0for the voltage-gated potassium channel KV1.1, taking\u00a0into account the channels\u2019 specific activation and inactivation characteristics close to physiological temperature. The modeling approach and simulation results\u00a0were compared with an existing Hodgkin Huxley\u00a0model based on the same experimental data. The\u00a0newly developed HMM shows a higher accuracy with\u00a0regard to the activation and inactivation behavior com-\u00a0pared to the Hodgkin Huxley approach.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[75],"application_areas":[50],"therapeutic_areas":[],"target_categories":[61],"target_families":[333],"targets":[248],"resource_keyword":[],"class_list":["post-6533","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-publication","application_areas-ion-channels","target_categories-voltage-gated-ion-channels","target_families-kv-channels","targets-kv1-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6533","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6533"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6533"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6533"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6533"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6533"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6533"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6533"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6533"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6533"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}