{"id":6389,"date":"2023-02-17T07:03:51","date_gmt":"2023-02-17T07:03:51","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/2020-chronic-hepatitis-c-virus-infection-impairs-insulin-secretion-by-regulation-of-p38%ce%b4-mapk-dependent-exocytosis-in-pancreatic-%ce%b2-cells\/"},"modified":"2023-02-17T07:03:51","modified_gmt":"2023-02-17T07:03:51","slug":"2020-chronic-hepatitis-c-virus-infection-impairs-insulin-secretion-by-regulation-of-p38%ce%b4-mapk-dependent-exocytosis-in-pancreatic-%ce%b2-cells","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2020-chronic-hepatitis-c-virus-infection-impairs-insulin-secretion-by-regulation-of-p38%ce%b4-mapk-dependent-exocytosis-in-pancreatic-%ce%b2-cells\/","title":{"rendered":"2020 &#8211; Chronic hepatitis C virus infection impairs insulin secretion by regulation of p38\u03b4 MAPK-dependent exocytosis in pancreatic \u03b2-cells"},"content":{"rendered":"<p>Chronic hepatitis C virus (HCV) infection has a close association with type 2 diabetes mellitus. Although the mechanisms of insulin resistance in chronic hepatitis C (CHC) patients have been extensively studied, little attention has been given to the role of \u03b2-cell function in HCV-associated diabetes. Here, we analysed \u03b2-cell function in CHC patients and HCV-infected mouse model and found in addition to insulin resistance, impaired pancreatic \u03b2-cell function occurred in CHC patients and HCV-infected C\/OTg mice, not only in diabetic individuals but also in individuals with impaired fasting glucose levels. Both first-phase and second-phase insulin secretion were impaired, at least partially due to the reduction of exocytosis of secretory insulin-containing granules following HCV infection. Up-regulated p38\u03b4 in HCV-infected \u03b2-cells resulted in inactivation of protein kinase D (PKD), which was responsible for impaired insulin secretory capacity of \u03b2-cells. Thus, impaired insulin secretion due to HCV infection in \u03b2-cells contributes to HCV-associated type 2 diabetes. These findings provided a new inspiration for the important prognostic and therapeutic implications in the management of CHC patients with impaired fasting glucose.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[75],"application_areas":[],"therapeutic_areas":[235],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-6389","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-publication","therapeutic_areas-metabolic-diseases"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6389","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6389"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6389"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6389"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6389"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6389"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6389"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6389"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6389"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6389"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}