{"id":6236,"date":"2023-02-17T07:03:00","date_gmt":"2023-02-17T07:03:00","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/2018-electrophysiological-experiments-in-microgravity-lessons-learned-and-future-challenges\/"},"modified":"2023-02-17T07:03:01","modified_gmt":"2023-02-17T07:03:01","slug":"2018-electrophysiological-experiments-in-microgravity-lessons-learned-and-future-challenges","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2018-electrophysiological-experiments-in-microgravity-lessons-learned-and-future-challenges\/","title":{"rendered":"2018 &#8211; Electrophysiological experiments in microgravity: lessons learned and future challenges"},"content":{"rendered":"<p>Advances in electrophysiological experiments have led to the discovery of mechanosensitive ion channels (MSCs) and the\u00a0identification of the physiological function of specific MSCs. They are believed to play important roles in mechanosensitive\u00a0pathways by allowing for cells to sense their mechanical environment. However, the physiological function of many MSCs has not been conclusively identified. Therefore, experiments have been developed that expose cells to various mechanical loads, such as\u00a0shear flow, membrane indentation, osmotic challenges and hydrostatic pressure. In line with these experiments, mechanical\u00a0unloading, as experienced in microgravity, represents an interesting alternative condition, since exposure to microgravity leads to a\u00a0series of physiological adaption processes. As outlined in this review, electrophysiological experiments performed in microgravity\u00a0have shown an influence of gravity on biological functions depending on ion channels at all hierarchical levels, from the cellular\u00a0level to organs. In this context, calcium signaling represents an interesting cellular pathway, as it involves the direct action of\u00a0calcium-permeable ion channels, and specific gravitatic cells have linked graviperception to this pathway. Multiple key proteins in\u00a0the graviperception pathways have been identified. However, measurements on vertebrae cells have revealed controversial results.\u00a0In conclusion, electrophysiological experiments in microgravity have shown that ion-channel-dependent physiological processes\u00a0are altered in mechanically unloaded conditions. Future experiments may provide a better understanding of the underlying\u00a0mechanisms.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45],"resource_type":[75],"application_areas":[50],"therapeutic_areas":[],"target_categories":[337,338],"target_families":[339,356,361,365,371],"targets":[123,126,128,217,237,280,281],"resource_keyword":[],"class_list":["post-6236","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","resource_type-publication","application_areas-ion-channels","target_categories-ligand-gated-ion-channels","target_categories-other-ion-channels","target_families-trp-channels","target_families-prokaryotic-mechanosensitive-channels","target_families-two-pore-domain-potassium-channels-k2p","target_families-piezo-channels","target_families-enac-channels","targets-mscl","targets-trpa1","targets-trpv4","targets-trpc1","targets-mscs","targets-enac","targets-piezo2"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6236","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6236"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6236"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6236"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6236"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6236"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6236"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6236"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6236"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6236"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}