{"id":6132,"date":"2023-02-17T06:56:19","date_gmt":"2023-02-17T06:56:19","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/2015-the-two-pore-domain-k2p-channel-task2-drives-human-nk-cell-proliferation-and-cytolytic-function\/"},"modified":"2023-02-17T06:56:19","modified_gmt":"2023-02-17T06:56:19","slug":"2015-the-two-pore-domain-k2p-channel-task2-drives-human-nk-cell-proliferation-and-cytolytic-function","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2015-the-two-pore-domain-k2p-channel-task2-drives-human-nk-cell-proliferation-and-cytolytic-function\/","title":{"rendered":"2015 &#8211; The two-pore domain K2P channel TASK2 drives human NK-cell proliferation and cytolytic function"},"content":{"rendered":"<p>Natural killer (NK) cells are a subset of cytotoxic lymphocytes that recognize and kill tumor\u2010 and virus\u2010infected cells without prior stimulation. Killing of target cells is a multistep process including adhesion to target cells, formation of an immunological synapse, and polarization and release of cytolytic granules. The role of distinct potassium channels in this orchestrated process is still poorly understood. The current study reveals that in addition to the voltage\u2010gated KV1.3 and the calcium\u2010activated KCa3.1 channels, human NK cells also express the two\u2010pore domain K2P channel TASK2 (TWIK\u2010related acid\u2010sensitive potassium channel). Expression of\u00a0Task2\u00a0varies among NK\u2010cell subsets and depends on their differentiation and activation state. Despite its different expression in TASK2highCD56brightCD16\u2212\u00a0and TASK2lowCD56dimCD16+\u00a0NK cells, TASK2 is involved in cytokine\u2010induced proliferation and cytolytic function of both subsets. TASK2 is crucial for leukocyte functional antigen (LFA\u20101) mediated adhesion of both resting and cytokine\u2010activated NK cells to target cells, an early step in killing of target cells. With regard to the following mechanism, TASK2 plays a role in release of cytotoxic granules by resting, but not IL\u201015\u2010induced NK cells. Taken together, our data exhibit two\u2010pore potassium channels as important players in NK\u2010cell activation and effector function.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[75],"application_areas":[50],"therapeutic_areas":[57],"target_categories":[61,335,338],"target_families":[333,354,361],"targets":[114,115,264],"resource_keyword":[],"class_list":["post-6132","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-publication","application_areas-ion-channels","therapeutic_areas-cancer","target_categories-voltage-gated-ion-channels","target_categories-intracellular-regulated-ion-channels","target_categories-other-ion-channels","target_families-kv-channels","target_families-calcium-and-sodium-activated-potassium-channels-kca-and-kna","target_families-two-pore-domain-potassium-channels-k2p","targets-kca3-1","targets-kv1-3","targets-task2-k2p5-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6132","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6132"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6132"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6132"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6132"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6132"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6132"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6132"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6132"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6132"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}