{"id":6109,"date":"2023-02-17T07:06:24","date_gmt":"2023-02-17T07:06:24","guid":{"rendered":"https:\/\/beta.nanion.de\/resource_library\/2014-structure-of-a-conserved-golgi-complex-targeting-signal-in-coronavirus-envelope-proteins\/"},"modified":"2023-02-17T07:06:24","modified_gmt":"2023-02-17T07:06:24","slug":"2014-structure-of-a-conserved-golgi-complex-targeting-signal-in-coronavirus-envelope-proteins","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2014-structure-of-a-conserved-golgi-complex-targeting-signal-in-coronavirus-envelope-proteins\/","title":{"rendered":"2014 &#8211; Structure of a Conserved Golgi Complex-targeting Signal in CoroNaVirus Envelope Proteins"},"content":{"rendered":"<p>CoroNaVirus envelope (CoV E) proteins are ~100-residue polypeptides with at least one channel-forming \u03b1-helical transmembrane (TM) domain. The extramembrane C terminal tail contains a completely conserved proline, at the center of a predicted \u03b2 coil \u03b2 motif. This hydrophobic motif has been reported to constitute a Golgi-targeting signal, or a second TM domain. However, no structural data for this, or other extramembrane domains in CoV E proteins, is available. Herein, we show that the E protein in the severe acute respiratory syndrome (SARS) virus has only one TM domain in micelles, whereas the predicted \u03b2 coil \u03b2 motif forms a short membrane-bound \u03b1 helix connected by a disordered loop to the TM domain. However, complementary results suggest that this motif is potentially poised for conformational change, or in dynamic exchange with other conformations.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[45,129],"resource_type":[75],"application_areas":[99],"therapeutic_areas":[109],"target_categories":[341],"target_families":[347],"targets":[256],"resource_keyword":[],"class_list":["post-6109","resource_library","type-resource_library","status-publish","hentry","products_tags-port-a-patch","products_tags-vesicle-prep-pro","resource_type-publication","application_areas-pores-and-toxins","therapeutic_areas-respiratory-diseases","target_categories-pores-and-toxins","target_families-pore-forming-toxins-and-antibiotics","targets-cov-e"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/6109","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=6109"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=6109"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=6109"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=6109"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=6109"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=6109"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=6109"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=6109"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=6109"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}