{"id":4843,"date":"2023-02-17T06:55:54","date_gmt":"2023-02-17T06:55:54","guid":{"rendered":"http:\/\/ionchanneltargets.com\/resource_library\/cardiac-ion-channels-simultaneous-assessment-of-cipa-stipulated-ion-channels-on-the-syncropatch-384pe\/"},"modified":"2023-02-17T06:55:55","modified_gmt":"2023-02-17T06:55:55","slug":"2011-pharmacological-studies-of-cav3-1-t-type-calcium-channels-using-automated-patch-clamp-techniques","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2011-pharmacological-studies-of-cav3-1-t-type-calcium-channels-using-automated-patch-clamp-techniques\/","title":{"rendered":"2011 &#8211; Pharmacological studies of CaV3.1 T-type calcium channels using automated patch-clamp techniques"},"content":{"rendered":"<p>T-type calcium channels are involved in a\u00a0variety of physiological and pathophysiological processes, and thus could be therapeutic targets. However, there is no T-type channel selective blocker for use in clinical practice, demanding a\u00a0need for the development of novel drugs where a\u00a0higher-throughput screening system is required. Here we present pharmacological studies on CaV3.1\u2009T-type channels using automated patch-clamp. The IC<sub>50<\/sub> values obtained from automated patch-clamp and conventional one showed a\u00a0good correlation (correlation coefficient of 0.82), suggesting that the automated patch-clamp is an efficient and reliable method for ranking the drug potencies for T-type channels.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[75],"application_areas":[50,53,76],"therapeutic_areas":[],"target_categories":[61],"target_families":[340],"targets":[228],"resource_keyword":[],"class_list":["post-4843","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-publication","application_areas-ion-channels","application_areas-assay-development-and-validation","application_areas-drug-discovery","target_categories-voltage-gated-ion-channels","target_families-cav-channels","targets-cav3-1"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/4843","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=4843"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=4843"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=4843"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=4843"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=4843"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=4843"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=4843"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=4843"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=4843"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}