{"id":18646,"date":"2025-11-07T10:28:56","date_gmt":"2025-11-07T08:28:56","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=18646"},"modified":"2025-11-07T10:28:56","modified_gmt":"2025-11-07T08:28:56","slug":"2025-insights-into-hepatic-neuronal-and-herg-channel-safety-of-plant-derived-active-compounds","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2025-insights-into-hepatic-neuronal-and-herg-channel-safety-of-plant-derived-active-compounds\/","title":{"rendered":"2025 &#8211; Insights into Hepatic, Neuronal, and hERG Channel Safety of Plant-Derived Active Compounds"},"content":{"rendered":"<p>Curcumin (CUR), atractylodin (ATD), \u03b1-mangostin (\u03b1MG), ethyl-p-methoxycinnamate (EPMC), ligustilide (LIG), and \u03b2-eudesmol (BEU) are commonly used in Thai traditional medicine formulations. This study evaluated the cytotoxic effects of these compounds in HepG2 liver cancer cells and ReNcell VM neural progenitor cells using the resazurin assay, as well as their potential for hERG inhibition in hERG-overexpressing HEK293 cells, utilizing the automated patch-clamp technique. \u03b1MG and CUR significantly reduced HepG2 cell viability (IC<sub>50<\/sub>\u00a0= 5.5 and 21 \u00b5M, respectively). In undifferentiated ReNcell VM cells, \u03b1MG was the most potent inhibitor of cell viability (IC<sub>50<\/sub>\u00a0= 2.1 \u00b5M), followed by CUR (IC<sub>50<\/sub>\u00a0= 21.1 \u00b5M), while in differentiated ReNcell VM cells, only \u03b1MG exhibited significant neurotoxicity (IC<sub>50<\/sub>\u00a0= 6.0 \u00b5M). Other compounds showed no significant effects on these cells. ATD, BEU, LIG, and EPMC demonstrated low inhibition of hERG channels (IC<sub>50<\/sub>\u00a0= 26.4, 33.4, 37.3, and 53 \u00b5M, respectively), while CUR and \u03b1MG displayed weak inhibitory effects (IC50 &gt; 100 \u00b5M). \u03b1MG may have cytotoxic effects on hepatocytes and neurons at concentrations much higher than when used as medicine or food supplements. At regular clinical doses, \u03b1MG, ATD, BEU, EPMC, LIG, and CUR are unlikely to cause significant side effects. However, if these compounds are considered for drug development, their potential effects on hERG channels should be carefully assessed to avoid possible cardiotoxicity. Pharmacokinetics, both preclinical and clinical studies, are necessary to understand the relationship between the plasma concentration profile of EPMC and its potential risks for hepatotoxicity, neurotoxicity, cardiotoxicity, and drug interactions.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[75],"application_areas":[50,53,76],"therapeutic_areas":[54,143],"target_categories":[61],"target_families":[333],"targets":[92],"resource_keyword":[],"class_list":["post-18646","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-publication","application_areas-ion-channels","application_areas-assay-development-and-validation","application_areas-drug-discovery","therapeutic_areas-cardiac-safety-cipa","therapeutic_areas-assay-development-and-validation","target_categories-voltage-gated-ion-channels","target_families-kv-channels","targets-kv11-1-herg"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/18646","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=18646"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=18646"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=18646"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=18646"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=18646"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=18646"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=18646"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=18646"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=18646"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}