{"id":17716,"date":"2025-07-14T08:44:55","date_gmt":"2025-07-14T08:44:55","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=17716"},"modified":"2025-07-14T08:44:55","modified_gmt":"2025-07-14T08:44:55","slug":"2025-amyloid-%ce%b2-1-42-can-form-ion-channels-as-small-as-gramicidin-in-model-lipid-membranes","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2025-amyloid-%ce%b2-1-42-can-form-ion-channels-as-small-as-gramicidin-in-model-lipid-membranes\/","title":{"rendered":"2025 &#8211; Amyloid \u03b2 1-42 Can Form Ion Channels as Small as Gramicidin in Model Lipid Membranes"},"content":{"rendered":"<p>The amyloid-beta 1-42 (A\u03b21-42) oligomers are the most cytotoxic species of the amyloid family and play a key role in the pathology of Alzheimer\u2019s Disease (AD). They have been shown to damage cellular membranes, but the exact mechanism is complex and not well understood. Multiple routes of membrane damage have been proposed, including the formation of pores and ion channels. In this work, we study the membrane damage induced by A\u03b21-42 oligomers using black lipid membrane (BLM) electrophysiology and compare their action with gramicidin, known to form ion channels. Our data show that A\u03b21-42 oligomers can induce a variety of damage in the lipid membranes composed of 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC), and cholesterol (CHOL), including small ion channels, similar to the gramicidin channels, with an average inner diameter smaller than 5 \u00c5. These channels have a short retaining time in lipid membranes, suggesting that they are highly dynamic. Our studies provide new insights into the mechanism of membrane damage caused by A\u03b21-42 oligomers and extend the current perception of the A\u03b2 channelopathy hypothesis. It provides a more in-depth understanding of the molecular mechanism by which small A\u03b2 oligomers induce cytotoxicity by interacting with lipid membranes in AD.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[40],"resource_type":[75],"application_areas":[53,99],"therapeutic_areas":[143],"target_categories":[341],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-17716","resource_library","type-resource_library","status-publish","hentry","products_tags-orbit-mini","resource_type-publication","application_areas-assay-development-and-validation","application_areas-pores-and-toxins","therapeutic_areas-assay-development-and-validation","target_categories-pores-and-toxins"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/17716","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=17716"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=17716"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=17716"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=17716"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=17716"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=17716"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=17716"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=17716"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=17716"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}