The interconnection between ageing, cancer development, and cellular growth suggests common origins despite distinct outward processes. The accumulation of cellular damage is widely acknowledged as a primary cause of ageing, potentially leading to abnormal cellular
\nadvantages (aberrant properties of cells, enabling them to bypass normal growth controls) and cancer. Uncontrolled cellular overgrowth is implicated in age-related pathologies like atherosclerosis and inflammation. Impedance analysis of mammalian cells grown on planar\u00a0 film electrodes provides a label-free, non-invasive and unbiased observation of cellular properties addressing the biological response to putative senescence inducers, drugs, toxins or stressors in general. Being label-free, automation and continuous monitoring of barrier function are among the most significant advantages offered by electrical techniques in comparison to macromolecular solute permeability studies.<\/p>\n
The label-free AtlaZ impedance recording system enables acute and chronic assessment of cellular toxicity as well as senescence in a continuous fashion from living cells under physiological temperatures and without the confounding effects of dyes that may affect cell function. The system uses 96-well plates with 96 parallel sensors offering a time resolution of down to 1 s for impedance measurements, thus allowing investigation of fast effects like GPCR related morphology changes. A frequency spectrum can be recorded ranging from 100 Hz \u2013 100 kHz.
\nIn general, cell adhesion and proliferation assays such as immune-cell -mediated killing of cancer cells can be successfully performed.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[419],"resource_type":[75],"application_areas":[53,77],"therapeutic_areas":[57,143],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-14768","resource_library","type-resource_library","status-publish","hentry","products_tags-atlaz","resource_type-publication","application_areas-assay-development-and-validation","application_areas-cell-ipscs-profiling","therapeutic_areas-cancer","therapeutic_areas-assay-development-and-validation"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/14768","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=14768"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=14768"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=14768"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=14768"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=14768"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=14768"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=14768"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=14768"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=14768"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}