{"id":14721,"date":"2024-06-27T07:21:35","date_gmt":"2024-06-27T07:21:35","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=14721"},"modified":"2024-06-27T07:21:35","modified_gmt":"2024-06-27T07:21:35","slug":"2024-a-non-b-dna-binding-peptidomimetic-channel-alters-cellular-functions","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2024-a-non-b-dna-binding-peptidomimetic-channel-alters-cellular-functions\/","title":{"rendered":"2024 &#8211; A non-B DNA binding peptidomimetic channel alters cellular functions"},"content":{"rendered":"<p>DNA binding transcription factors possess the ability to interact with lipid membranes to construct ion-permeable pathways. Herein, we present a thiazole-based DNA binding peptide mimic\u00a0TBP2, which forms transmembrane ion channels, impacting cellular ion concentration and consequently stabilizing G-quadruplex DNA structures.\u00a0TBP2\u00a0self-assembles into nanostructures, e.g., vesicles and nanofibers and facilitates the transportation of Na<sup>+<\/sup>\u00a0and K<sup>+<\/sup>\u00a0across lipid membranes with high conductance (~0.6 nS). Moreover,\u00a0TBP2\u00a0exhibits increased fluorescence when incorporated into the membrane or in cellular nuclei. Monomeric\u00a0TBP2\u00a0can enter the lipid membrane and localize to the nuclei of cancer cells. The coordinated process of time-dependent membrane or nuclear localization of\u00a0TBP2, combined with elevated intracellular cation levels and direct G-quadruplex (G4) interaction, synergistically promotes formation and stability of G4 structures, triggering cancer cell death. This study introduces a platform to mimic and control intricate biological functions, leading to the discovery of innovative therapeutic approaches.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[129],"resource_type":[75],"application_areas":[53],"therapeutic_areas":[143],"target_categories":[341],"target_families":[],"targets":[242],"resource_keyword":[],"class_list":["post-14721","resource_library","type-resource_library","status-publish","hentry","products_tags-vesicle-prep-pro","resource_type-publication","application_areas-assay-development-and-validation","therapeutic_areas-assay-development-and-validation","target_categories-pores-and-toxins","targets-dna-nanopores"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/14721","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=14721"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=14721"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=14721"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=14721"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=14721"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=14721"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=14721"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=14721"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=14721"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}