{"id":13250,"date":"2024-01-08T09:42:38","date_gmt":"2024-01-08T09:42:38","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=13250"},"modified":"2024-01-08T09:42:38","modified_gmt":"2024-01-08T09:42:38","slug":"2023-a-simple-quantitative-model-of-neuromodulation-part-i-ion-flow-through-neural-ion-channels","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2023-a-simple-quantitative-model-of-neuromodulation-part-i-ion-flow-through-neural-ion-channels\/","title":{"rendered":"2023 &#8211; A simple quantitative model of neuromodulation, Part I: Ion flow through neural ion channels"},"content":{"rendered":"<p>We develop a simple model of ionic current through neuronal membranes as a function of membrane potential and extracellular\u00a0ion concentration. The model combines a simplified Poisson\u2013Nernst\u2013Planck (PNP) model of ion transport through individual ion channels with channel\u00a0activation functions\u00a0calibrated from\u00a0<em>ad hoc<\/em>\u00a0in-house experimental data. The simplified PNP model is validated against bacterial gramicidin A ion channel data. The calibrated model accounts for the transport of calcium, sodium,\u00a0potassium, and chloride and exhibits remarkable agreement with the experimentally measured current\u2013voltage curves for the differentiated human neural cells. All relevant data and code related to the ion flow models are available at Werneck et al. (2023)<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[41],"resource_type":[75],"application_areas":[50],"therapeutic_areas":[55],"target_categories":[],"target_families":[],"targets":[],"resource_keyword":[],"class_list":["post-13250","resource_library","type-resource_library","status-publish","hentry","products_tags-buffer-solutions","resource_type-publication","application_areas-ion-channels","therapeutic_areas-cns"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/13250","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=13250"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=13250"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=13250"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=13250"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=13250"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=13250"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=13250"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=13250"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=13250"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}