{"id":11616,"date":"2023-07-03T09:30:17","date_gmt":"2023-07-03T09:30:17","guid":{"rendered":"https:\/\/www.nanion.de\/?post_type=resource_library&#038;p=11616"},"modified":"2023-07-03T09:30:17","modified_gmt":"2023-07-03T09:30:17","slug":"2023-pain-causing-stinging-nettle-toxins-target-tmem233-to-modulate-nav1-7-function","status":"publish","type":"resource_library","link":"https:\/\/nanion.com\/ja\/resource_library\/2023-pain-causing-stinging-nettle-toxins-target-tmem233-to-modulate-nav1-7-function\/","title":{"rendered":"2023 &#8211; Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function"},"content":{"rendered":"<p>Voltage-gated sodium (Na<sub>V<\/sub>) channels are critical regulators of neuronal excitability and are targeted by many toxins that directly interact with the pore-forming \u03b1 subunit, typically via extracellular loops of the voltage-sensing domains, or residues forming part of the pore domain. Excelsatoxin A (ExTxA), a pain-causing knottin peptide from the Australian stinging tree\u00a0<i>Dendrocnide excelsa<\/i>, is the first reported plant-derived Na<sub>V<\/sub>\u00a0channel modulating peptide toxin. Here we show that TMEM233, a member of the dispanin family of transmembrane proteins expressed in sensory neurons, is essential for pharmacological activity of ExTxA at Na<sub>V<\/sub>\u00a0channels, and that co-expression of TMEM233 modulates the gating properties of Na<sub>V<\/sub>1.7. These findings identify TMEM233 as a previously unknown Na<sub>V<\/sub>1.7-interacting protein, position TMEM233 and the dispanins as\u00a0accessory proteins that are indispensable for toxin-mediated effects on Na<sub>V<\/sub>\u00a0channel gating, and provide important insights into the function of Na<sub>V<\/sub>\u00a0channels in sensory neurons.<\/p>\n<p>Read more in the publication <a href=\"https:\/\/www.nature.com\/articles\/s41467-023-37963-2\">here<\/a>.<\/p>\n","protected":false},"featured_media":0,"template":"","products_tags":[44],"resource_type":[75],"application_areas":[50],"therapeutic_areas":[56],"target_categories":[61],"target_families":[332],"targets":[116,418],"resource_keyword":[],"class_list":["post-11616","resource_library","type-resource_library","status-publish","hentry","products_tags-patchliner","resource_type-publication","application_areas-ion-channels","therapeutic_areas-pain","target_categories-voltage-gated-ion-channels","target_families-nav-channels","targets-nav1-7","targets-tmem233"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library\/11616","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_library"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/resource_library"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=11616"}],"wp:term":[{"taxonomy":"products_tags","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/products_tags?post=11616"},{"taxonomy":"resource_type","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_type?post=11616"},{"taxonomy":"application_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/application_areas?post=11616"},{"taxonomy":"therapeutic_areas","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/therapeutic_areas?post=11616"},{"taxonomy":"target_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_categories?post=11616"},{"taxonomy":"target_families","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/target_families?post=11616"},{"taxonomy":"targets","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/targets?post=11616"},{"taxonomy":"resource_keyword","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/resource_keyword?post=11616"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}