{"id":14362,"date":"2022-07-27T06:46:33","date_gmt":"2022-07-27T04:46:33","guid":{"rendered":"https:\/\/www.nanion.de\/application-areas\/ion-channels\/"},"modified":"2025-10-23T06:49:57","modified_gmt":"2025-10-23T04:49:57","slug":"ion-channels","status":"publish","type":"page","link":"https:\/\/nanion.com\/ja\/application-areas\/ion-channels\/","title":{"rendered":"Ion channels"},"content":{"rendered":"<div id=\"pl-14362\" class=\"panel-layout\"><div id=\"pg-14362-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14362-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-14362-0-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-14362\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Ion channels<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tIon channels are our expertise.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-14362-1\"><div id=\"pgc-14362-1-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"white-text panel-widget-style panel-widget-style-for-14362-1-0-0\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-14362\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1510738160{\n        width: ;\n        height: ;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1510738160 .image{\n        width: calc(100% + );\n        height: calc(100% + );\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-1379652026\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1510738160\" data-mark>\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/22E4601xw_840x1040.jpg\" style><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/22E4601xw_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2>Controlling <strong>cellular excitability<\/strong> and permeability<\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Ion channels are complex proteins that control the flow of ions across cell and organelle membranes. They can be gated by transmembrane voltage or neurotransmitters, and respond to endogenous ligands or environmental agents. Ion channels are present in every cell type and thereby control neuronal excitability, cardiac, skeletal, and smooth muscle contraction, and hormone release. Their ubiquitous location and varied function, alongside genetic mutations associated with many human diseases, make them attractive drug discovery targets.&nbsp; Exploring ion channel function has yielded successful therapeutics for pain, epilepsy, diabetes, and cardiac and vascular disease.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-1379652026 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-1379652026 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-1379652026\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-1379652026\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14362-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14362-2-1\" class=\"panel-grid-cell\"><div id=\"panel-14362-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Structure and function of<\/h2>\n<h2><strong>ion channels<\/strong><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14362-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14362-3\"><div id=\"pgc-14362-3-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-14362-3-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14362\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Functional and Phylogenetic Classification <\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14362-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14362-3-1\"><div id=\"panel-14362-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Ion channels are divided into voltage- and ligand-gated families, with unique voltage sensor, ligand-binding and pore domains. Each subunit consists of four to six transmembrane domains, and three, four or five combine as homo or heteromers to create ion channels with varied biophysics and pharmacology. As well as ligands and voltage, other stimuli such as pressure\/stretch and temperature can activate certain ion channels.<\/p>\n<p>The widespread expression and specialized function of ion channels make them important targets for neuroscience, neurodegeneration, hormone secretion, muscle function, cardiac safety, and cancer.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14362-3-1-1\" class=\"so-panel widget widget_sow-image panel-last-child\" data-index=\"5\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-14362\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms.png\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms.png\" width=\"4000\" height=\"2250\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms.png 4000w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-300x169.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-1024x576.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-768x432.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-1536x864.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-2048x1152.png 2048w\" sizes=\"(max-width: 4000px) 100vw, 4000px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%204000%202250%22%3E%3C%2Fsvg%3E\" width=\"4000\" height=\"2250\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%204000%202250%22%3E%3C%2Fsvg%3E 4000w\" sizes=\"(max-width: 4000px) 100vw, 4000px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms.png 4000w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-300x169.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-1024x576.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-768x432.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-1536x864.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms-2048x1152.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Ion-channels-dendrograms.png\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-4\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14362-4-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14362-4-1\" class=\"panel-grid-cell\"><div id=\"panel-14362-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Ways to measure<\/strong><\/h2>\n<h2>ion channels<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14362-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14362-5\"><div id=\"pgc-14362-5-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-5-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"7\"><div class=\"panel-widget-style panel-widget-style-for-14362-5-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14362\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channel electrophysiology<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14362-5-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14362-5-1\"><div id=\"panel-14362-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Patch clamp electrophysiology remains the gold standard for studying complex biophysical properties of ion channels, and for investigating state-dependence and selectivity of ion channel modulators. However, conventional patch clamp is notoriously low throughput and requires skilled personnel to perform the experiments. <a href=\"\/product-categories\/automated-patch-clamp\/\" target=\"_blank\" rel=\"noopener\">Automated patch clamp<\/a> has emerged as a viable alternative to conventional patch clamp and enables rapid and high throughput testing of single disease-related mutations in large ion channel proteins to improve disease diagnosis and treatment based on precise biophysical and pharmacological profiling. Large compound libraries can be screened in a short amount of time and selectivity and safety experiments can be performed with ease and at high throughput. Combining electrophysiology with other techniques such as cryo-EM and impedance can also provide extra information about the interaction of molecules with ion channels and their knock-on effects on cell health and contractility.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-6\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14362-6\"><div id=\"pgc-14362-6-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-6-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"9\"><div class=\"panel-widget-style panel-widget-style-for-14362-6-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14362\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Multiple modes of activation<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14362-6-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14362-6-1\"><div id=\"panel-14362-6-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The recording of ligand-gated ion channels requires fast and precise application of external ligand. This is achieved on the <a href=\"\/products\/port-a-patch\/\" target=\"_blank\" rel=\"noopener\">Port-a-Patch<\/a> via the External Perfusion System, and on the <a href=\"\/products\/patchliner\/\" target=\"_blank\" rel=\"noopener\">Patchliner<\/a> and <a href=\"\/products\/syncropatch-384\/\" target=\"_blank\" rel=\"noopener\">SyncroPatch 384<\/a> by stacking solutions inside the pipettes and rapid application of ligand using a high pipetting speed. Recording of voltage-gated ion channels requires good whole-cell access and accurate voltage control which is achieved through the borosilicate glass chips, suction application to get good whole-cell access, and high-quality amplifiers. Sophisticated experiments involving rapid and transient heat activation of TRP channels can be performed using the temperature control of the Patchliner, whilst heat and cold activation of channels can be done on the Port-a-Patch and SyncroPatch 384. Pressure activation of ion channels can be achieved using suction or shear stress via the pipette. With the automated patch clamp instruments from Nanion, molecules and ions can be easily applied in the internal solution thereby facilitating research on Ca<sup>2+<\/sup> or Na<sup>+<\/sup>-activated ion channels.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-7\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14362-7\"><div id=\"pgc-14362-7-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-7-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"11\"><div class=\"panel-widget-style panel-widget-style-for-14362-7-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14362\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Investigating PIEZO1 using the Patchliner<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14362-7-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14362-7-1\"><div id=\"panel-14362-7-1-0\" class=\"so-panel widget widget_sow-image panel-first-child\" data-index=\"12\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-14362\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/Nanion_Target_Note_PL_Piezo.pdf?1677676061\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720.png\" width=\"1200\" height=\"720\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720.png 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-300x180.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-1024x614.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-768x461.png 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E\" width=\"1200\" height=\"720\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20720%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720.png 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-300x180.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-1024x614.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720-768x461.png 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Piezo_1200x720.png\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><div id=\"panel-14362-7-1-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"13\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>PIEZO channels are mechanically activated cation channels, mediating various health and disease mechanisms such as red blood cell homeostasis, malarial resistance, vascular structure and function, and lymphoedema. The 2021 Nobel Prize for Physiology or Medicine was awarded in part for the discovery of ion channels responsible for touch, recognizing their crucial role in physiology and pathophysiology. A bottleneck in drug development targeting PIEZO channels has been the lack of patch clamp systems capable of applying mechanical stimulation in an automated, higher throughput manner. Nanion\u2019s Patchliner enables mechanical stimulation of PIEZO1 channels in an automated patch clamp instrument, allowing for reliable quantification of PIEZO1 activation by fluid flow and Yoda1.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14362-7-1-2\" class=\"so-panel widget widget_filedownload-theme-widget\" data-index=\"14\"><div class=\"so-widget-filedownload-theme-widget so-widget-filedownload-theme-widget-default-d75171398898-14362\">    <div class=\"filedownload-widget\">\n        <div class=\"download-list\"> \n                            <div class=\"download-item\">\n                    <a href=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/06\/Nanion_Flyer_A4_Piezo1_PL_2023_Web-version_final.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        <span class=\"title\">Download Application Note <\/span>\n                        <span class=\"desc\"><\/span>\n                    <\/a>\n                <\/div>\n                        <\/div>\n    <\/div>\n    <\/div><\/div><div id=\"panel-14362-7-1-3\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"15\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-14362\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/target-database\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tTarget database\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14362-8\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14362-8\" data-stretch-type=\"full\"><div id=\"pgc-14362-8-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14362-8-0\"><div id=\"panel-14362-8-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"16\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-14362-8-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-14362\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tMeasuring biophysics and pharmacology\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14362-8-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14362-8-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"17\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3>Using electrophysiology to precisely understand <strong>ion channel function<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-14362-8-1-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"18\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>We provide a range of electrophysiology platforms to study ion channels in native and heterologous cells and membranes:<\/p>\n<ul>\n<li>Single channel recordings on <a href=\"\/products\/orbit-mini\/\">Orbit mini<\/a> and <a href=\"\/products\/orbit-16-tc\/\">Orbit 16 TC<\/a> platforms can resolve state transitions and ion permeation of individual ion channel proteins in native or artificial membranes.<\/li>\n<li>Whole-cell recordings on <a href=\"\/products\/port-a-patch\/\">Port-a-Patch<\/a>, <a href=\"\/products\/patchliner\/\">Patchliner <\/a>and <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a> can reveal ion channel selectivity, voltage-dependent biophysics and ligand-activation, as well as pharmacology of modulators and the effects of accessory subunits and second messengers.<\/li>\n<li>The <a href=\"\/products\/surfe2r-n1\/\">SURFE<sup>2<\/sup>R N1<\/a> and <a href=\"\/products\/surfer-96se\/\">SURFE<sup>2<\/sup>R 96SE<\/a> platforms can measure ion channel and transporter activity in organellar membranes.<\/li>\n<\/ul>\n<p>These platforms can be used to study basic mechanisms of ion channel function, their role in cellular physiology, effects of patient and disease-derived mutations (channelopathies), and screen for new drugs.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14362-8-1-2\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"19\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-14362\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/products\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\">\n\t\t<span>\n\t\t\t\n\t\t\tSee our product areas\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14362-8-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-14362-9\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-14362-9\"><div id=\"pgc-14362-9-0\" class=\"panel-grid-cell\"><div id=\"panel-14362-9-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"20\"><div id=\"pl-w6787aa9aaa0f8\" class=\"panel-layout\"><div id=\"pg-w6787aa9aaa0f8-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6787aa9aaa0f8-0\"><div id=\"pgc-w6787aa9aaa0f8-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w6787aa9aaa0f8-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w6787aa9aaa0f8-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6787aa9aaa0f8-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6787aa9aaa0f8-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6787aa9aaa0f8-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6787aa9aaa0f8-1\"><div id=\"pgc-w6787aa9aaa0f8-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787aa9aaa0f8-1-0\"><div id=\"panel-w6787aa9aaa0f8-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6787aa9aaa0f8-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Alison Obergrussberger (Director of Scientific Sales and Customer Engagement). Alison is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787aa9aaa0f8-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787aa9aaa0f8-1-1\"><div id=\"panel-w6787aa9aaa0f8-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6787aa9aaa0f8-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:Ali.Obergrussberger@nanion.de\">Ali.Obergrussberger@nanion.de<br>\n<\/a><\/strong><br>\nor call:&nbsp;<strong>+49 89 2190 95-078<\/strong><br>\nor connect via&nbsp;<strong><a href=\"https:\/\/www.linkedin.com\/in\/ali-obergrussberger-89ba8710\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787aa9aaa0f8-1-2\" 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});\n<\/script><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Ion channels Ion channels are our expertise. Controlling cellular excitability and permeability Ion channels a [&hellip;]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":14360,"menu_order":38,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"class_list":["post-14362","page","type-page","status-publish","hentry"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/pages\/14362","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/comments?post=14362"}],"version-history":[{"count":5,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/pages\/14362\/revisions"}],"predecessor-version":[{"id":18539,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/pages\/14362\/revisions\/18539"}],"up":[{"embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/pages\/14360"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=14362"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}