{"id":14358,"date":"2022-08-30T09:13:24","date_gmt":"2022-08-30T07:13:24","guid":{"rendered":"https:\/\/www.nanion.de\/therapeutic-areas\/metabolic-diseases\/"},"modified":"2026-02-03T14:13:41","modified_gmt":"2026-02-03T12:13:41","slug":"metabolic-diseases","status":"publish","type":"page","link":"https:\/\/nanion.com\/ja\/therapeutic-areas\/metabolic-diseases\/","title":{"rendered":"Metabolic diseases"},"content":{"rendered":"<div id=\"pl-14358\" class=\"panel-layout\"><div id=\"pg-14358-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14358-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-14358-0-0\" class=\"panel-grid-cell\"><div id=\"panel-14358-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-14358\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Metabolic diseases<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tAffecting the body\u2019s homeostatic functions.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14358-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-14358-1\"><div id=\"pgc-14358-1-0\" class=\"panel-grid-cell\"><div id=\"panel-14358-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-14358\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1308727294{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1308727294 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-725196535\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1308727294\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Metabolic_840x1040.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Metabolic_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2>Accelerating <strong>metabolic disease research<\/strong><\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Metabolic diseases, inborn errors of metabolism, include changes in cellular activity, and genetic mutations affecting proteins. As each organ has a specialized function, changes in gene expression, protein localization, and cell activity can affect glucose (pancreas), water, acid and salt (kidney), hormone levels (pituitary and adrenal glands), and protein and lipid homeostasis (liver). Also, gene mutations can alter protein function in mitochondria, affecting energy production and activity of muscle and brain cells, in organelles by disturbing lysosomal storage, and the liver. Some metabolic diseases can now be cured with gene therapies and enzyme replacement treatments.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-725196535 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-725196535 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-725196535\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-725196535\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-14358-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14358-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14358-2-1\" class=\"panel-grid-cell\"><div id=\"panel-14358-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Metabolic<\/strong> ion channels<\/h2>\n<h2>and transporters<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14358-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14358-3\"><div id=\"pgc-14358-3-0\" class=\"panel-grid-cell\"><div id=\"panel-14358-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-14358-3-0-0\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14358\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Varied targets<br> and mechanisms<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14358-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14358-3-1\"><div id=\"panel-14358-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Metabolic diseases are complex and varied and involve a wide range of mechanisms, genes, and proteins expressed in many cell types and organs in the periphery as well as the brain. Owing to their role in many basic cellular functions, ion channels and transporters are potential therapeutic targets for several metabolic diseases. In the case of endocrinological metabolic ailments, there are ion channels that regulate hormone release through modulation of membrane excitability (e.g. Na<sub>v<\/sub> and K<sub>v<\/sub> channels), secretion (Ca<sup>2+<\/sup> channels), and gene expression. A classic example is K-ATP (Kir6.x) channels which regulate pancreatic \u03b2 cell insulin secretion and are the target of diabetes mellitus drugs such as tolbutamide, glibenclamide (glyburide), repaglinide, and nateglinide. As rare metabolic diseases include lysosomal storage disorders, the role of ion channels and transporters to regulate organelle ionic homeostasis, secretory and phagocytic function, and trafficking has revealed new targets for drug development. Transporters such as SGLT1 also regulate solute transport across many cell membranes, with the potential to ameliorate changes in sugars and nutrients in metabolic diseases.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14358-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14358-4\"><div id=\"pgc-14358-4-0\" class=\"panel-grid-cell\"><div id=\"panel-14358-4-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"5\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14358\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Measuring SGLT1 on SURFE<sup>2<\/sup>R N1: EC<sub>50<\/sub> for D-glucose transport<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-14358-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14358-4-1\"><div id=\"panel-14358-4-1-0\" class=\"so-panel widget widget_sow-image panel-first-child\" data-index=\"6\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-14358\">\n<div class=\"sow-image-container\">\n\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R.png\" width=\"1569\" height=\"627\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R.png 1569w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-300x120.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-1024x409.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-768x307.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-1536x614.png 1536w\" sizes=\"(max-width: 1569px) 100vw, 1569px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201569%20627%22%3E%3C%2Fsvg%3E\" width=\"1569\" height=\"627\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201569%20627%22%3E%3C%2Fsvg%3E 1569w\" sizes=\"(max-width: 1569px) 100vw, 1569px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R.png 1569w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-300x120.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-1024x409.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-768x307.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R-1536x614.png 1536w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/01\/SGLT1-traces-from-SURFE2R.png\">\n\t<\/div>\n\n<\/div><\/div><div id=\"panel-14358-4-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The figure shows the detection of Na<sup>+<\/sup>\/sugar translocation using a sugar concentration jump in presence of sodium. Here we determined the KM for glucose transport by SGLT1. We performed a single solution exchange workflow by applying a D-glucose concentration jump in presence of 300 mM Na<sup>+<\/sup>. By application of different D-glucose concentrations in the range between 1 mM and 250 mM on the same sensor, we could determine the EC<sub>50<\/sub> for D-glucose transport by SGLT1. We have used the same concentration of Mannitol as compensation in each substrate-free solution.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14358-5\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14358-5-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14358-5-1\" class=\"panel-grid-cell\"><div id=\"panel-14358-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Assay platforms<\/strong> for<\/h2>\n<h2>metabolic disease targets<\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14358-6\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14358-6-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14358-6-0\"><div id=\"panel-14358-6-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"9\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-14358-6-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-14358\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tMembrane transporters and channels\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14358-6-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14358-6-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The <a href=\"\/products\/surfe2r-n1\/\" target=\"_blank\" rel=\"noopener\">SURFE<sup>2<\/sup>R N1<\/a> and&nbsp; <a href=\"\/products\/surfer-96se\/\" target=\"_blank\" rel=\"noopener\">SURFE<sup>2<\/sup>R 96SE<\/a> can measure ion and substrate flow by transporters and ion channels associated with metabolic disease. The activity of proteins inserted into bilayers or endogenously within native plasmalemma and organelle membranes can be biophysically and pharmacologically characterized to enable a better understanding of metabolic disease mechanisms and to screen for novel modulators.<\/p>\n<p>A diverse set of transporters regulate the transfer of solutes, neurotransmitters, and counter-ions across cell membranes, with the potential to ameliorate pathophysiological changes in sugars and nutrients in metabolic disease. For example, the SGLT1 sodium-glucose co-transporter is responsible for the absorption of sugars from the gut and the reclamation of glucose from urine in the kidney. As ion channels and transporters regulate organelle ionic homeostasis, secretory and phagocytic function, and trafficking this makes them attractive drug targets to treat lysosomal storage and related metabolic diseases.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14358-6-1-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"11\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-14358\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources\/resource-library\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tLearn more\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14358-6-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-14358-7\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-14358-7\"><div id=\"pgc-14358-7-0\" class=\"panel-grid-cell\"><div id=\"panel-14358-7-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"12\"><div id=\"pl-w6981e675a465e\" class=\"panel-layout\"><div id=\"pg-w6981e675a465e-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e675a465e-0\"><div id=\"pgc-w6981e675a465e-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w6981e675a465e-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w6981e675a465e-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6981e675a465e-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6981e675a465e-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6981e675a465e-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6981e675a465e-1\"><div id=\"pgc-w6981e675a465e-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e675a465e-1-0\"><div id=\"panel-w6981e675a465e-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6981e675a465e-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Cecilia George (Global Head of SURFE<sup>2<\/sup>R Sales \/ Senior Scientist&nbsp;). Cecilia is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e675a465e-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6981e675a465e-1-1\"><div id=\"panel-w6981e675a465e-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6981e675a465e-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:cecilia.george@nanion.de\">cecilia.george@nanion.de<\/a><\/strong><\/p>\n<p>or connect via&nbsp;<strong><a href=\"https:\/\/www.linkedin.com\/in\/cecilia-george-75102ba\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6981e675a465e-1-2\" class=\"panel-grid-cell\"><div id=\"panel-w6981e675a465e-1-2-0\" class=\"so-panel widget 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