{"id":14353,"date":"2022-08-30T09:05:22","date_gmt":"2022-08-30T07:05:22","guid":{"rendered":"https:\/\/www.nanion.de\/therapeutic-areas\/channels-in-pain\/"},"modified":"2025-10-23T06:41:10","modified_gmt":"2025-10-23T04:41:10","slug":"channels-in-pain","status":"publish","type":"page","link":"https:\/\/nanion.com\/ja\/therapeutic-areas\/channels-in-pain\/","title":{"rendered":"Pain"},"content":{"rendered":"<div id=\"pl-14353\" class=\"panel-layout\"><div id=\"pg-14353-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14353-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-14353-0-0\" class=\"panel-grid-cell\"><div id=\"panel-14353-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-14353\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>Pain<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tThe search for novel non-opioid analgesics.\n\n<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14353-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-14353-1\"><div id=\"pgc-14353-1-0\" class=\"panel-grid-cell\"><div id=\"panel-14353-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-14353\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1315238966{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1315238966 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-2014105861\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1315238966\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain_840x1040.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain_840x1040.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2><strong>Channeling Relief:<\/strong> The role of ion channels in pain<\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>Pain is an unpleasant physical sensation caused by injury or inflammation in sensory nerves and surrounding tissues, increasing action potential firing in hypersensitized neurons which pass these signals to the spinal cord and up to pain processing centers in the brain. Its goal is to prevent further injury and protect our body\u2019s well-being. However, chronic pain, affecting up to 40% of the human population, is a condition where pain persists even when the underlying cause is no longer present. This can become debilitating and is currently not well managed by available medications. Ion channels have been implicated in pain pathways and are major therapeutic targets for chronic pain treatment. By more specific targeting of certain ion channels, drugs may become safer, with fewer side effects and lower addiction risk.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-2014105861 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-2014105861 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-2014105861\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-2014105861\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-14353-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14353-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14353-2-1\" class=\"panel-grid-cell\"><div id=\"panel-14353-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Ion channels as<strong> pain targets<em>\n<p><\/p><\/em><\/strong><\/h2>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14353-3\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14353-3-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14353-3-0\"><div id=\"panel-14353-3-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"3\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-14353-3-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-14353\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tPain as a channelopathy\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14353-3-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14353-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Human sensory pathways inform us about our environment. Ion channels localized in primary sensory neurons and other relevant neuronal structures are involved in pain processing. Among these channels, sodium (eg. Na<sub>V<\/sub>1.7 and Na<sub>V<\/sub>1.8), calcium, transient receptor potential (TRP), and PIEZO and purinergic P2X3 channels have been flagged as great potential drug targets to combat chronic pain. In 2021, the Nobel Prize was awarded for deciphering the ion channel-mediated mechanisms for how the nervous system senses pressure and temperature. Interestingly, both of identified channels have also been implicated in allodynia (Piezo2) and analgesia in chronic neuropathic pain (TRPV1).<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14353-3-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"5\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-14353\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_.jpg\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_.jpg\" width=\"1200\" height=\"754\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_.jpg 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-300x189.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-1024x643.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-768x483.jpg 768w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20754%22%3E%3C%2Fsvg%3E\" width=\"1200\" height=\"754\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201200%20754%22%3E%3C%2Fsvg%3E 1200w\" sizes=\"(max-width: 1200px) 100vw, 1200px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_.jpg 1200w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-300x189.jpg 300w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-1024x643.jpg 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_-768x483.jpg 768w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Pain-Therapeuitc-areas-in-text_1200x754_.jpg\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><div id=\"panel-14353-3-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Figure adapted from <a href=\"https:\/\/www.nature.com\/articles\/s41583-021-00444-w\" target=\"_blank\" rel=\"noopener\">Goodwin, G., McMahon, S.B. The physiological function of different voltage-gated sodium channels in pain. <i>Nat Rev Neurosci<\/i>&nbsp;<b>22<\/b>, 263\u2013274 (2021)<\/a>.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14353-3-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-14353-4\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14353-4-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14353-4-0\"><div id=\"panel-14353-4-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"7\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-14353-4-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-14353\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tAlleviating pain\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14353-4-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14353-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Among currently approved drugs, almost 20% of drugs targeting human receptors, target ion channels. Nevertheless, pain drug targets go in and out of fashion, and mostly so due to poor clinical results. TRPV1 and TRPA1 modulators and Ca<sub>V<\/sub>2.2 channels are slowly being forgotten, however, work on Na<sub>V<\/sub>1.7 and Na<sub>V<\/sub>1.8 channels continues due to human genetic channelopathies and promising clinical success. K<sub>V<\/sub>7.x channel and a9a10 nAChRs modulators are also being developed, alongside P2X receptors activated by inflammation. NMDA GluR and GABA<sub>A<\/sub> ligand-gated receptors are still relevant CNS drug targets.<\/p>\n<p>Importantly, pharmacological benchmarking gives confidence that hits identified in screening campaigns are genuine and allows a comparison of the effects of new compounds with the literature. High throughput patch clamp screening platforms, such as the <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a> also allow for gene family selectivity screening of hit and lead compounds on a single plate. Imagine testing six different Na<sub>V<\/sub>1.x cell lines with the same state-dependent voltage protocol allowing for the potency and selectivity of each compound to be determined quickly and under similar conditions. Screens like these are very much possible, and routinely taking place in research facilities today.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14353-4-1-1\" class=\"so-panel widget widget_sow-image\" data-index=\"9\"><div class=\"so-widget-sow-image so-widget-sow-image-default-334eeca80698-14353\">\n<div class=\"sow-image-container\">\n\t\t\t<a href=\"\/wp-content\/uploads\/2023\/02\/Nanion_APP_Note_384PE_hNaV1_8_06013.pdf?1677677457\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t\t<noscript><img src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain.png\" width=\"1838\" height=\"2094\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain.png 1838w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-263x300.png 263w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-899x1024.png 899w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-768x875.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-1348x1536.png 1348w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-1798x2048.png 1798w\" sizes=\"(max-width: 1838px) 100vw, 1838px\" alt class=\"so-widget-image\"><\/noscript><img src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201838%202094%22%3E%3C%2Fsvg%3E\" width=\"1838\" height=\"2094\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%201838%202094%22%3E%3C%2Fsvg%3E 1838w\" sizes=\"(max-width: 1838px) 100vw, 1838px\" alt class=\"so-widget-image lazyload\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain.png 1838w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-263x300.png 263w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-899x1024.png 899w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-768x875.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-1348x1536.png 1348w, https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain-1798x2048.png 1798w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/Nav1.8_Pain.png\">\n\t\t\t<\/a><\/div>\n\n<\/div><\/div><div id=\"panel-14353-4-1-2\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>The figure shows raw traces of current responses to increasing voltage steps from -60 to +60 mV (A) from an exemplar CHO cell expressing hNa<sub>V<\/sub>1.8 recorded on the SyncroPatch 384PE (predecessor of SyncroPatch 384; <strong>A<\/strong>).&nbsp; Current-voltage plot (<strong>B<\/strong>) shows the mean of peak amplitudes normalized to the maximum of each cell \u00b1 S.E.M. for an average of 380 cells. We used a double voltage step protocol for the pharmacology experiments, and screenshot (<strong>C<\/strong>) of the data acquisition software shows the time course of current amplitudes after applying the two-step pulse protocol.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14353-4-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-14353-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14353-5\"><div id=\"pgc-14353-5-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14353-5-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14353-5-1\"><div id=\"panel-14353-5-1-0\" class=\"so-panel widget widget_filedownload-theme-widget panel-first-child panel-last-child\" data-index=\"11\"><div class=\"so-widget-filedownload-theme-widget so-widget-filedownload-theme-widget-default-d75171398898-14353\">    <div class=\"filedownload-widget\">\n        <div class=\"download-list\"> \n                            <div class=\"download-item\">\n                    <a href=\"\/wp-content\/uploads\/2023\/02\/Nanion_APP_Note_384PE_hNaV1_8_06013.pdf?1677677457\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        <span class=\"title\">Download Application Note<\/span>\n                        <span class=\"desc\"><\/span>\n                    <\/a>\n                <\/div>\n                        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14353-6\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14353-6-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14353-6-1\" class=\"panel-grid-cell\"><div id=\"panel-14353-6-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"12\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Tools for studying<\/strong><\/h2>\n<h2>pain-related ion channels<\/h2>\n<p>&nbsp;<\/p>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14353-7\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14353-7-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14353-7-0\"><div id=\"panel-14353-7-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"13\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-14353-7-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-f63c946382f4-14353\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tPain ion channel screening\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14353-7-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14353-7-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"14\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>As pain-related ion channels utilize a wide variety of activation and stimulation mechanisms, identifying and screening for those ion channels as drug targets demands high flexibility and precision. When identifying drugs of choice, speed, throughput, and easy-to-use software protocols are paramount. Our<a href=\"\/product-categories\/automated-patch-clamp\/\"> automated patch clamp (APC) systems<\/a> can accurately measure and analyze activation, inactivation, IC<sub>50 <\/sub>\/ EC<sub>50<\/sub> parameters, and important metrics in the drug discovery of new pain-related ion channel modulators.<\/p>\n<p>High-quality, high-resolution recordings of the complex biophysics of voltage-gated pain channels (e.g. Na<sub>V<\/sub>1.7, Na<sub>V<\/sub>1.8, K<sub>V<\/sub>7.x, and HCN2), are possible by employing excellent voltage control and seal quality. Ligand-gated receptor responses (e.g. TRPV1, TRPA1, ASIC1a) can be reliably measured using flexible liquid application techniques. Implementation in translational studies of pain-related ion channels and receptors in human iPSC-derived sensory neurons helps bridge the gap from <em>in vitro<\/em> screening to preclinical studies and clinical development of novel pain drugs, ultimately improving millions of lives around the planet.<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14353-7-1-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"15\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-14353\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources-for-automated-patch-clamp-membrane-biophysics-and-cell-analytics\/resource-library\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tLearn more\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14353-7-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-14353-8\" class=\"panel-grid panel-has-style\"><div class=\"bg-left panel-row-style panel-row-style-for-14353-8\"><div id=\"pgc-14353-8-0\" class=\"panel-grid-cell\"><div id=\"panel-14353-8-0-0\" class=\"so-panel widget widget_siteorigin-panels-builder panel-first-child panel-last-child\" data-index=\"16\"><div id=\"pl-w6787ab3c00389\" class=\"panel-layout\"><div id=\"pg-w6787ab3c00389-0\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6787ab3c00389-0\"><div id=\"pgc-w6787ab3c00389-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w6787ab3c00389-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child panel-last-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w6787ab3c00389-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-087580a7c05b\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab3c00389-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6787ab3c00389-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6787ab3c00389-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6787ab3c00389-1\"><div id=\"pgc-w6787ab3c00389-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787ab3c00389-1-0\"><div id=\"panel-w6787ab3c00389-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6787ab3c00389-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Alison Obergrussberger (Director of Scientific Sales and Customer Engagement). Alison is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab3c00389-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787ab3c00389-1-1\"><div id=\"panel-w6787ab3c00389-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6787ab3c00389-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:Ali.Obergrussberger@nanion.de\">Ali.Obergrussberger@nanion.de<br>\n<\/a><\/strong><br>\nor call:&nbsp;<strong>+49 89 2190 95-078<\/strong><br>\nor connect via&nbsp;<strong><a href=\"https:\/\/www.linkedin.com\/in\/ali-obergrussberger-89ba8710\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab3c00389-1-2\" 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