{"id":14352,"date":"2022-08-30T09:03:48","date_gmt":"2022-08-30T07:03:48","guid":{"rendered":"https:\/\/www.nanion.de\/therapeutic-areas\/cns\/"},"modified":"2025-10-23T06:40:52","modified_gmt":"2025-10-23T04:40:52","slug":"cns","status":"publish","type":"page","link":"https:\/\/nanion.com\/ja\/therapeutic-areas\/cns\/","title":{"rendered":"CNS"},"content":{"rendered":"<div id=\"pl-14352\" class=\"panel-layout\"><div id=\"pg-14352-0\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14352-0\" data-stretch-type=\"full-width-stretch\"><div id=\"pgc-14352-0-0\" class=\"panel-grid-cell\"><div id=\"panel-14352-0-0-0\" class=\"so-panel widget widget_general-text-widget panel-first-child panel-last-child\" data-index=\"0\"><div class=\"so-widget-general-text-widget so-widget-general-text-widget-title-widget-de16310f3dd9-14352\"><style>\n    <\/style>\n<div class=\"container simple-header-section \">\n\t<div class=\"titlewidget-section\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 300\">\n\t\t<svg class=\"bf-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M8.6,104.7V16.3H0V0h26v9.5v6.7v88.4v4.4v11.9H0v-16.3H8.6z\" \/>\n\t\t<\/svg>\n\n\t\t<svg class=\"bf-text\">\n\t\t\t<path d=\"M0.5,0.3V23h12v123h-12v22.7h36.3v-16.5V146V23v-9.4V0.3H0.5z\" \/>\n\t\t<\/svg>\n\t\t\n\t\t<div class=\"title-box\">\n\t\t\t\t\t\t\n\t\t\t\t<div class=\"texttitle\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 400\">\n\t\t\t\t\t<h1>CNS<\/h1>\n<\/div>\n\t\t\t\t\t\t\n\n\t\t\t\t\t\t\t<h4 class=\"titledescription\" uk-scrollspy=\"cls:uk-animation-slide-bottom; delay: 500\">\n\t\t\t\t\tThe role of ion channels and transporters in neurological disease.<\/h4>\n\t\t\t\n\t\t<\/div>\n\n\t\t<svg class=\"at-text\">\n\t\t\t<path d=\"M25.2,146.2V22.8h12V0H0.8v13.3v9.4v123.5v6.2V169h36.3v-22.8H25.2z\" \/>\n\t\t\t<\/svg>\n\t\t\n\t\t<svg class=\"at-text-mobile\">\t\n\t\t\t<path class=\"st0\" d=\"M17.4,104.7V16.3H26V0H0v9.5v6.7v88.4v4.4v11.9h26v-16.3H17.4z\" \/>\n\t\t<\/svg>\n\t<\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14352-1\" class=\"panel-grid panel-has-style\"><div class=\"bg-right panel-row-style panel-row-style-for-14352-1\"><div id=\"pgc-14352-1-0\" class=\"panel-grid-cell\"><div id=\"panel-14352-1-0-0\" class=\"so-panel widget widget_read-more-widget panel-first-child panel-last-child\" data-index=\"1\"><div class=\"so-widget-read-more-widget so-widget-read-more-widget-default-d75171398898-14352\"><style>\n    \/*.read-more-section .image-wrapper #box-img-1769291283{\n        width: 420px;\n        height: 520px;\n    }*\/\n    .read-more-section .image-wrapper #box-img-1769291283 .image{\n        width: calc(100% + 12%);\n        height: calc(100% + 12%);\n    }\n<\/style>\n<div class=\"read-more-section row\" id=\"readmore-1620899175\">\n                            <div class=\"col-12 col-md-4 image-wrapper order-0\"> <!--data-aos=\"fade-down\" data-aos-offset=\"700\" data-aos-duration=\"5000\" data-aos-once=\"true\"-->\n                        <div class=\"box-img\" id=\"box-img-1769291283\" data-mark=\"12%\">\n                            <noscript><img decoding=\"async\" class=\"image\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CNS_840x1040-1.jpg\" style=\"bottom:-18%\"><\/noscript><img decoding=\"async\" class=\"image lazyload\" src=\"data:image\/gif;base64,R0lGODlhAQABAIAAAAAAAP\/\/\/yH5BAEAAAAALAAAAAABAAEAAAIBRAA7\" style=\"bottom:-18%\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/02\/CNS_840x1040-1.jpg\">\n                        <\/div>\n                <\/div>\n                    <div class=\"col-12 col-md-8 text-wrapper order-1\">\n        <div class=\"title\">\n            <h2><strong>Brainstorming solutions:<\/strong> Navigating the complex world of neurological disease<\/h2>\n        <\/div>\n                    <div class=\"description focus-description \">\n                <p>The brain is the most complex organ in the body, using chemical, electrical and genetic signaling and structural remodeling to process and store information. Voltage- and ligand-gated ion channels and transporters control and modulate neurotransmitter release, re-uptake, and neuronal excitability. Mutations and functional changes in many of those ion channels and transporters are associated with common and rare diseases such as epilepsy and pain. Complex central nervous system (CNS) diseases such as autism, schizophrenia, depression, developmental syndromes, and neurodegeneration also include a role for ion channels in neurons, glia, and inflammatory microglia as early triggers of excitability changes or disease modifiers.<\/p>\n            <\/div>\n            \n    <\/div>\n<\/div>\n\n<script>\n    jQuery(document).ready(function($){\n        jQuery('.read-more-section a[href^=\"tel:\"]').addClass('no-underline');\n\n        if($(document).width() <= 992){\n            let imgHeight = $(\"#readmore-1620899175 .image-wrapper >.box-img\").height();\n            readMoreSetMgB(imgHeight);\n        }else{\n            readMoreSetMgB(0);\n        }\n        $(window).resize(function(){\n            if($(document).width() <= 992){\n                let imgHeight = $(\"#readmore-1620899175 .image-wrapper >.box-img\").height();\n                readMoreSetMgB(imgHeight);\n            }else{\n                readMoreSetMgB(0);\n            }\n        })\n\n        function readMoreSetMgB(imgHeight){\n            \/*console.log('height '+imgHeight);*\/\n            if(imgHeight > 0){\n                $(\"#readmore-1620899175\").closest('.panel-grid').css('margin-bottom',(imgHeight)+'px');\n            }else{\n                $(\"#readmore-1620899175\").closest('.panel-grid').css('margin-bottom','');\n            }\n        }\n    });\n\n<\/script>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-14352-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14352-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14352-2-1\" class=\"panel-grid-cell\"><div id=\"panel-14352-2-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2>Ion channels control CNS<\/h2>\n<h2><strong>excitability and neurodegeneration<\/strong><\/h2>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14352-3\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14352-3\"><div id=\"pgc-14352-3-0\" class=\"panel-grid-cell\"><div id=\"panel-14352-3-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"3\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14352\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Ion channels is epilepsy<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-14352-3-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14352-3-1\"><div id=\"panel-14352-3-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>One of the major CNS diseases involving ion channels is epilepsy. There are thousands of mutations in Na<sub>V<\/sub>, Ca<sub>V<\/sub>, and KCNQ channels and GABA<sub>A<\/sub> ionotropic receptors found in human patients, making it the 4<sup>th<\/sup> most common neurological disease. Gain-of-function mutations in excitatory Na<sub>V<\/sub> channels and loss-of-function mutations in inhibitory KCNQ channels are expected to promote epileptic seizures. However, the cellular context of each ion channel is also important. Gain-of-function mutations in Na<sub>V<\/sub> channels in excitatory neurons underlie specific forms of epilepsy (e.g. Na<sub>V<\/sub>1.2 in GEFS, Na<sub>V<\/sub>1.6 in DEE13 and SUDEP), but loss-of-function mutations in other Na<sub>V<\/sub> channels in inhibitory interneurons underlie patient seizures (e.g. Na<sub>V<\/sub>1.1 in Dravet syndrome). Researchers are therefore looking for both activators and inhibitors of CNS ion channels implicated in rare and common forms of epilepsy. High throughput patch clamp electrophysiology is essential for this work, both to enable a detailed biophysical study of numerous epilepsy ion channel mutations, and to facilitate the efficient screening and discovery of new ion channel ligands to prevent seizures.<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-14352-3-1-1\" class=\"so-panel widget widget_filedownload-theme-widget panel-last-child\" data-index=\"5\"><div class=\"so-widget-filedownload-theme-widget so-widget-filedownload-theme-widget-default-d75171398898-14352\">    <div class=\"filedownload-widget\">\n        <div class=\"download-list\"> \n                            <div class=\"download-item\">\n                    <a href=\"https:\/\/nanion.com\/wp-content\/uploads\/2023\/03\/145209_2020_Channelopathy_piece_AlGeorge_A4_web.pdf\" target=\"_blank\" rel=\"noopener noreferrer\">\n                        <span class=\"title\">Download Case Study featuring Prof. Alfred L. George, Jr., MD, Northwestern University and Jen Pan, Ph.D., Broad Institute<\/span>\n                        <span class=\"desc\"><\/span>\n                    <\/a>\n                <\/div>\n                        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14352-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-14352-4\"><div id=\"pgc-14352-4-0\" class=\"panel-grid-cell\"><div id=\"panel-14352-4-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"6\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14352\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Mechanisms of neurodegeneration<\/h4><\/div><\/div><\/div><\/div><div id=\"pgc-14352-4-1\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14352-4-1\"><div id=\"panel-14352-4-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Neuronal hyperexcitability is an early symptom in neurodegenerative diseases and can lead to cell injury and death, which manifests as chronic and progressive neurodegeneration in patients suffering from Alzheimer\u2019s, ALS, Parkinson\u2019s disease, and frontotemporal dementia. Researchers are developing modulators of depolarising (e.g. Na<sub>V<\/sub>, Ca<sub>V<\/sub>) and hyperpolarising (K<sub>V<\/sub>7.x) ion channels as a mechanism to control neuronal hyperexcitability and reduce neurodegenerative cell loss and dementia symptoms.<\/p>\n<p>Another role for ion channels in neurodegeneration involves their regulation of lysosomal organelles. Changes in organelle ionic balance mediated by ion channels such as TMEM175, TRPML1, and TPC help regulate the recycling and degradation of faulty and toxic proteins by the ubiquitin-proteasome pathway, thereby removing protein tangles in neurodegenerative diseases. Also, genetic changes in organelle ion channels are associated with an increased risk of some CNS neurodegenerative and metabolic diseases, making them attractive targets for academic research and drug discovery. It is difficult to study ion channels in organelle membranes with traditional patch clamp techniques, but SURFE<sup>2<\/sup>R and Orbit platforms can achieve this with ease.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-14352-5\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14352-5-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14352-5-1\" class=\"panel-grid-cell\"><div id=\"panel-14352-5-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h2><strong>Automated patch clamp: <\/strong><strong><br>\n<\/strong>ideal technique to study<\/h2>\n<h2>disease-related ion channel mutations<\/h2>\n<h2><\/h2>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-14352-6\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14352-6-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-14352-6-0\"><div id=\"panel-14352-6-0-0\" class=\"so-panel widget widget_characters-max-header-widget panel-first-child panel-last-child\" data-index=\"9\"><div class=\"so-widget-characters-max-header-widget so-widget-characters-max-header-widget-default-d75171398898-14352\"><div class=\"characters-max-header\">\n\t<h4 style=\"color: #77c2a1;font-weight: 700;\">Profiling ion channel mutations in CNS<\/h4><\/div><\/div><\/div><\/div><\/div><div id=\"pgc-14352-6-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14352-6-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"10\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Challenges of studying CNS disease-related channelopathies, such as rapid profiling of many patient mutations and high-fidelity recordings to discriminate subtle biophysical changes in current density, channel kinetics, and voltage dependence, are very well addressed by automated patch clamp, such as <a href=\"\/products\/patchliner\/\">Patchliner<\/a> and <a href=\"\/products\/syncropatch-384\/\">SyncroPatch 384<\/a>. Understanding the actual, rather than predicted, effect of ion channel mutations is required to categorize them as benign or pathophysiological, and guide drug treatment and clinical prognosis. Rapid acquisition of high-quality and information-rich patch clamp data on ion channel mutants also enables sophisticated machine learning and protein modeling methods to predict loss- or gain-of-function and pathogenicity. These methods have been successfully applied to Na<sub>V<\/sub>1.1, Na<sub>V<\/sub>1.2, Na<sub>V<\/sub>1.6, and KCNQ channel mutations from epilepsy patients, as well as channelopathies associated with other CNS neurological diseases such as schizophrenia, Alzheimer\u2019s disease, autism, and intellectual disability.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14352-6-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-14352-7\" class=\"panel-grid panel-has-style\"><div class=\"siteorigin-panels-stretch panel-row-style panel-row-style-for-14352-7\" data-stretch-type=\"full\"><div id=\"pgc-14352-7-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><div id=\"pgc-14352-7-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14352-7-1-0\" class=\"so-panel widget widget_media_video panel-first-child\" data-index=\"11\"><div style=\"width:100%;\" class=\"wp-video\"><video class=\"wp-video-shortcode\" id=\"video-14352-1\" preload=\"metadata\" controls=\"controls\"><source type=\"video\/youtube\" src=\"https:\/\/www.youtube.com\/watch?v=Z_Px6od4Ia0&#038;_=1\"><a href=\"https:\/\/www.youtube.com\/watch?v=Z_Px6od4Ia0\">https:\/\/www.youtube.com\/watch?v=Z_Px6od4Ia0<\/a><\/video><\/div><\/div><div id=\"panel-14352-7-1-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"12\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p class=\"uk-article-title\"><strong>Accelerating Ion Channel Characterization and New Drug Candidate Identification <\/strong><\/p>\n<p><strong>Speakers:<\/strong><\/p>\n<p>Alfred George, M.D.<br>\nChair, Department of Pharmacology,&nbsp;Northwestern University Feinberg School of Medicine<\/p>\n<p>Matt Fuller, Ph.D.<br>\nSenior Scientist,&nbsp;Icagen<\/p>\n<p><em>Organisation: Icagen Inc.<\/em><\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14352-7-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-14352-8\" class=\"panel-grid panel-no-style\"><div id=\"pgc-14352-8-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><div class=\"panel-cell-style panel-cell-style-for-14352-8-0\"><\/div><\/div><div id=\"pgc-14352-8-1\" class=\"panel-grid-cell panel-grid-cell-mobile-last\"><div id=\"panel-14352-8-1-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"13\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-10f3526e3813-14352\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/resources-for-automated-patch-clamp-membrane-biophysics-and-cell-analytics\/resource-library\/\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tLearn more\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><div id=\"pgc-14352-8-2\" class=\"panel-grid-cell 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class=\"sow-headline\">\n\t\t\t\t\t\tHow can we  help you?\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab57acf6e-0-1\" class=\"panel-grid-cell panel-grid-cell-empty panel-grid-cell-mobile-last\"><\/div><div id=\"pgc-w6787ab57acf6e-0-2\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><\/div><div id=\"pg-w6787ab57acf6e-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w6787ab57acf6e-1\"><div id=\"pgc-w6787ab57acf6e-1-0\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787ab57acf6e-1-0\"><div id=\"panel-w6787ab57acf6e-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"1\"><div class=\"panel-widget-style panel-widget-style-for-w6787ab57acf6e-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Contact our specialist Dr. Alison Obergrussberger (Director of Scientific Sales and Customer Engagement). Alison is delighted to help you:<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab57acf6e-1-1\" class=\"panel-grid-cell\"><div class=\"tablet-50 panel-cell-style panel-cell-style-for-w6787ab57acf6e-1-1\"><div id=\"panel-w6787ab57acf6e-1-1-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w6787ab57acf6e-1-1-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong><a href=\"mailto:Ali.Obergrussberger@nanion.de\">Ali.Obergrussberger@nanion.de<br>\n<\/a><\/strong>or call: <strong>+49 89 2190 95-078<\/strong><br>\nor connect via&nbsp;<strong><a href=\"https:\/\/www.linkedin.com\/in\/ali-obergrussberger-89ba8710\/\" target=\"_blank\" rel=\"noopener\">LinkedIn<\/a><\/strong><\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pgc-w6787ab57acf6e-1-2\" class=\"panel-grid-cell\"><div 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