{"id":19779,"date":"2026-10-01T11:19:59","date_gmt":"2026-10-01T09:19:59","guid":{"rendered":"https:\/\/nanion.com\/?post_type=news&#038;p=19779"},"modified":"2026-10-02T17:26:39","modified_gmt":"2026-10-02T15:26:39","slug":"webinar-exploring-cftr-function-and-pharmacology","status":"publish","type":"news","link":"https:\/\/nanion.com\/ja\/news\/webinar-exploring-cftr-function-and-pharmacology\/","title":{"rendered":"Webinar: Exploring CFTR function and pharmacology"},"content":{"rendered":"<div id=\"pl-19779\" class=\"panel-layout\"><div id=\"pg-19779-0\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19779-0-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-0-0-0\" class=\"so-panel widget widget_text panel-first-child\" data-index=\"0\">\t\t\t<div class=\"textwidget\"><p data-pm-slice=\"1 1 []\"><strong>Date:<\/strong>&nbsp; Thursday, November 5, 2026<br>\n<strong>Time:<\/strong> 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n<p>How can functional assays help researchers understand CFTR activity and evaluate responses to potential therapies?<\/p>\n<p>Join Professor Fr\u00e9d\u00e9ric Becq and Dr. John Lueck for a webinar bringing together perspectives on CFTR research and experimental approaches to studying its function. Explore how measurements of channel activity and epithelial barrier properties can support the investigation of CFTR variants and their responses to pharmacological modulation.<\/p>\n<\/div>\n\t\t<\/div><div id=\"panel-19779-0-0-1\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"1\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-19779\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\" download>\n\t\t<span>\n\t\t\t\n\t\t\tRegister here\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-19779-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19779-1\"><div id=\"pgc-19779-1-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-1-0-0\" class=\"so-panel widget widget_saleforce-form-theme-widget panel-first-child panel-last-child\" data-index=\"2\"><div class=\"so-widget-saleforce-form-theme-widget so-widget-saleforce-form-theme-widget-default-d75171398898-19779\">    <div class=\"modal fade modal-sf-form\" id=\"sf_form_popup\" tabindex=\"-1\" aria-labelledby=\"sf_form_popup\" aria-hidden=\"true\">\n        <div class=\"modal-dialog modal-dialog-scrollable modal-dialog-centered\">\n            <div class=\"modal-content\">\n                <div class=\"modal-body\">\n                    <button type=\"button\" class=\"close\" data-dismiss=\"modal\" aria-label=\"Close\">\n                        <span aria-hidden=\"true\"><\/span>\n                    <\/button>\n    <div id=\"pl-w37a6259c\" class=\"panel-layout\"><div id=\"pg-w37a6259c-0\" class=\"panel-grid panel-has-style\"><div class=\"headline-group panel-row-style panel-row-style-for-w37a6259c-0\"><div id=\"pgc-w37a6259c-0-0\" class=\"panel-grid-cell\"><div id=\"panel-w37a6259c-0-0-0\" class=\"so-panel widget widget_sow-headline panel-first-child\" data-index=\"0\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w37a6259c-0-0-0\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-b8ea6da32558\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h4 class=\"sow-headline\">\n\t\t\t\t\t\tPlease fill out the form \t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-w37a6259c-0-0-1\" class=\"so-panel widget widget_sow-headline panel-last-child\" data-index=\"1\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w37a6259c-0-0-1\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-3ac3da29e399\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tRegister for the webinar\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-w37a6259c-1\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-w37a6259c-1\"><div id=\"pgc-w37a6259c-1-0\" class=\"panel-grid-cell\"><div id=\"panel-w37a6259c-1-0-0\" class=\"widget_text so-panel widget widget_custom_html panel-first-child panel-last-child\" data-index=\"2\"><div class=\"widget_text panel-widget-style panel-widget-style-for-w37a6259c-1-0-0\"><div class=\"textwidget custom-html-widget\"><script>\njQuery(function($){\n\tvar url = window.location.href;\n\t$('input[name=\"retURL\"]').val(url + '?callaction=toggle-thankyou');\n});\n<\/script>\n\n<style>\n.salesforce-form {\n    background-color: #ffffff;\n    padding: 30px;\n}\n\n#thankyou_popup .modal-content {\n    background-color: #ffffff !important;\n}\n\n#thankyou_popup .modal-body {\n    padding: 60px !important;\n}\n<\/style>\n\n<div class=\"salesforce-form\">\n<!--  ----------------------------------------------------------------------  -->\n<!--  NOTE: Please add the following <META> element to your page <HEAD>.      -->\n<!--  If necessary, please modify the charset parameter to specify the        -->\n<!--  character set of your HTML page.                                        -->\n<!--  ----------------------------------------------------------------------  -->\n<meta http-equiv=\"Content-type\" content=\"text\/html; charset=UTF-8\">\n\n\t\n<!--  ----------------------------------------------------------------------  -->\n<!--  NOTE: Please add the following <FORM> element to your page.             -->\n<!--  ----------------------------------------------------------------------  -->\n<form action=\"https:\/\/webto.salesforce.com\/servlet\/servlet.WebToLead?encoding=UTF-8\" method=\"POST\" class=\"wpcf7-form\">\n\t<input type=\"hidden\" name=\"oid\" value=\"00D58000000ae2A\">\n\t<input type=\"hidden\" name=\"retURL\" value>\n\t<!--  ----------------------------------------------------------------------  -->\n\t<!--  NOTE: These fields are optional debugging elements. 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value=\"Somalia\">Somalia<\/option>\n\t\t\t<option value=\"South Africa\">South Africa<\/option>\n\t\t\t<option value=\"South Korea\">South Korea<\/option>\n\t\t\t<option value=\"South Sudan\">South Sudan<\/option>\n\t\t\t<option value=\"Spain\">Spain<\/option>\n\t\t\t<option value=\"Sri Lanka\">Sri Lanka<\/option>\n\t\t\t<option value=\"Sudan\">Sudan<\/option>\n\t\t\t<option value=\"Suriname\">Suriname<\/option>\n\t\t\t<option value=\"Sweden\">Sweden<\/option>\n\t\t\t<option value=\"Switzerland\">Switzerland<\/option>\n\t\t\t<option value=\"Syria\">Syria<\/option>\n\t\t\t<option value=\"Taiwan\">Taiwan<\/option>\n\t\t\t<option value=\"Tajikistan\">Tajikistan<\/option>\n\t\t\t<option value=\"Tanzania\">Tanzania<\/option>\n\t\t\t<option value=\"Thailand\">Thailand<\/option>\n\t\t\t<option value=\"Timor-Leste\">Timor-Leste<\/option>\n\t\t\t<option value=\"Togo\">Togo<\/option>\n\t\t\t<option value=\"Tonga\">Tonga<\/option>\n\t\t\t<option value=\"Trinidad and Tobago\">Trinidad and 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received\t\t\t\t\t\t<\/h4>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><div id=\"panel-w37a6259c-0-0-1\" class=\"so-panel widget widget_sow-headline panel-last-child\" data-index=\"1\"><div class=\"all-font-bold panel-widget-style panel-widget-style-for-w37a6259c-0-0-1\"><div class=\"so-widget-sow-headline so-widget-sow-headline-default-3ac3da29e399\"><div class=\"sow-headline-container \">\n\t\t\t\t\t\t\t<h2 class=\"sow-headline\">\n\t\t\t\t\t\tThanks for registering!\t\t\t\t\t\t<\/h2>\n\t\t\t\t\t\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-w37a6259c-1\" class=\"panel-grid panel-has-style\"><div class=\"content-group panel-row-style panel-row-style-for-w37a6259c-1\"><div id=\"pgc-w37a6259c-1-0\" class=\"panel-grid-cell\"><div id=\"panel-w37a6259c-1-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"2\"><div class=\"panel-widget-style panel-widget-style-for-w37a6259c-1-0-0\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p class=\"isSelectedEnd\">We\u2019ve received your details and will send you more information about the webinar shortly.<\/p>\n<p>If you have any questions in the meantime, feel free to get in touch with our team.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><div id=\"pg-w37a6259c-2\" class=\"panel-grid panel-has-style\"><div class=\"button-group panel-row-style panel-row-style-for-w37a6259c-2\"><div id=\"pgc-w37a6259c-2-0\" class=\"panel-grid-cell\"><div class=\"panel-cell-style panel-cell-style-for-w37a6259c-2-0\"><div id=\"panel-w37a6259c-2-0-0\" class=\"so-panel widget widget_sow-button panel-first-child panel-last-child\" data-index=\"3\"><div class=\"panel-widget-style panel-widget-style-for-w37a6259c-2-0-0\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"mailto:team.marketing@nanion.de\" class=\"btn-primary sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tContact us\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>                <\/div>\n            <\/div>\n        <\/div>\n    <\/div>\n    <\/div><\/div><\/div><\/div><\/div><div id=\"pg-19779-2\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19779-2-0\" class=\"panel-grid-cell panel-grid-cell-empty\"><\/div><\/div><div id=\"pg-19779-3\" class=\"panel-grid panel-no-style\"><div id=\"pgc-19779-3-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-3-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"3\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Agenda<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19779-3-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"4\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<ul>\n<li><strong>Introduction<\/strong><\/li>\n<li><strong>Professor Fr\u00e9d\u00e9ric&nbsp;Becq<\/strong> (University of Poitiers) - <em>Unraveling the Pharmacology of Disease-Causing CFTR Variants Using Automated Patch Clamp method for Theratyping.<\/em><\/li>\n<li>\n<p data-pm-slice=\"1 1 []\"><strong>Dr. John Lueck <\/strong>(University of Rochester Medical Center) -&nbsp;<em>Making Sense of Nonsense: ACE-tRNAs as Platform Therapeutics for Nonsense Mutations.<\/em><\/p>\n<\/li>\n<li><strong>Discussion<\/strong> (joint Q&amp;A session)<\/li>\n<li><strong>Closing words<\/strong><\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><div id=\"pg-19779-4\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19779-4\"><div id=\"pgc-19779-4-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-4-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"5\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Who should attend?<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19779-4-0-1\" class=\"so-panel widget widget_sow-editor\" data-index=\"6\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>This webinar is relevant for researchers working in:<\/p>\n<ul>\n<li data-pm-slice=\"1 1 []\">Cystic fibrosis<\/li>\n<li data-pm-slice=\"1 1 []\">Epithelial physiology<\/li>\n<li data-pm-slice=\"1 1 []\">Ion channels<\/li>\n<li data-pm-slice=\"1 1 []\">Assay development<\/li>\n<li data-pm-slice=\"1 1 []\">Drug discovery<\/li>\n<\/ul>\n<p>\ud83d\udc49 Register now to join the live discussion and Q&amp;A session<\/p>\n<\/div>\n<\/div><\/div><div id=\"panel-19779-4-0-2\" class=\"so-panel widget widget_sow-button panel-last-child\" data-index=\"7\"><div class=\"so-widget-sow-button so-widget-sow-button-flat-24c0153bf600-19779\"><div class=\"ow-button-base ow-button-align-left\">\n\t\t\t<a href=\"\/webinar-registration-2\/\" class=\"btn-primary sf-form sowb-button ow-icon-placement-left ow-button-hover\" target=\"_blank\" rel=\"noopener noreferrer\">\n\t\t<span>\n\t\t\t\n\t\t\tRegister for the webinar\t\t<\/span>\n\t\t\t<\/a>\n\t<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-19779-5\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19779-5\"><div id=\"pgc-19779-5-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-5-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"8\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<h3><strong>Talk abstracts<\/strong><\/h3>\n<\/div>\n<\/div><\/div><div id=\"panel-19779-5-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"9\"><div class=\"so-widget-sow-editor so-widget-sow-editor-base\">\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p><strong>Unraveling the Pharmacology of Disease-Causing CFTR Variants Using Automated Patch Clamp method for <\/strong><strong>Theratyping.<\/strong><\/p>\n<p data-start=\"1167\" data-end=\"1212\"><strong data-start=\"1167\" data-end=\"1179\">Speaker:&nbsp;<\/strong>Fr\u00e9d\u00e9ric Becq,&nbsp;University of Poitiers<\/p>\n<p>The cystic fibrosis transmembrane conductance regulator (CFTR) is an epithelial anion channel encoded by the CFTR gene. Cystic fibrosis (CF) is a life-limiting autosomal recessive disorder caused by pathogenic CFTR variants that can disrupt multiple stages of CFTR biogenesis and function, including mRNA stability, protein folding, trafficking, and channel activity. More than 2,100 CFTR variants have been identified to date, although only a subset have been definitively established as disease-causing.<\/p>\n<p>Theratyping refers to the functional characterization of disease-associated variants to determine whether, and to what extent, they respond to targeted therapies. This approach is particularly relevant for rare CFTR variants for which clinical evidence is limited or unavailable. In the context of CF, theratyping can therefore represent a key experimental component of a theranostic approach (a broader precision-medicine strategy that integrates diagnostic information with therapeutic decision-making). By leveraging the molecular and functional characteristics of an individual's CFTR variant, theratyping may help guide the selection of appropriate therapies, particularly when clinical evidence is insufficient.<\/p>\n<p>Here, we describe the use of automated patch clamp electrophysiology with the Nanion Patchliner system as a tool to investigate the functional defects associated with disease-causing CFTR variants and to assess their correction by CFTR modulators.<\/p>\n<h4><\/h4>\n<p>&nbsp;<\/p>\n<p><strong>Making Sense of Nonsense: ACE-tRNAs as Platform Therapeutics for Nonsense Mutations<\/strong><\/p>\n<p><strong>Speaker:&nbsp;<\/strong>Dr. John Lueck, University of Rochester Medical Center<\/p>\n<p data-pm-slice=\"1 1 []\">Real-time monitoring of epithelial resistance provides insights into CFTR function and responses to pharmacological modulation. This talk explores the use of the AtlaZ platform for continuous, label-free measurements of epithelial barrier properties and CFTR-dependent changes in impedance.<\/p>\n<p>Using epithelial cell models expressing wild-type or F508del-CFTR, we examine responses to CFTR activation, inhibition, and modulator treatment, alongside comparisons with Ussing chamber recordings. These examples illustrate how impedance-based assays can complement established electrophysiological methods and support higher-throughput studies of CFTR variants and potential therapeutic compounds.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><div id=\"pg-19779-6\" class=\"panel-grid panel-has-style\"><div class=\"panel-row-style panel-row-style-for-19779-6\"><div id=\"pgc-19779-6-0\" class=\"panel-grid-cell\"><div id=\"panel-19779-6-0-0\" class=\"so-panel widget widget_media_image panel-first-child panel-last-child\" data-index=\"10\"><noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png\" class=\"image wp-image-19780  attachment-full size-full\" alt style=\"max-width: 100%; height: auto;\" srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-2048x1192.png 2048w\" sizes=\"(max-width: 2560px) 100vw, 2560px\"><\/noscript><img decoding=\"async\" width=\"2560\" height=\"1490\" src=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E\" class=\"image wp-image-19780  attachment-full size-full lazyload\" alt style=\"max-width: 100%; height: auto;\" srcset=\"data:image\/svg+xml,%3Csvg%20xmlns%3D%22http%3A%2F%2Fwww.w3.org%2F2000%2Fsvg%22%20viewBox%3D%220%200%202560%201490%22%3E%3C%2Fsvg%3E 2560w\" sizes=\"(max-width: 2560px) 100vw, 2560px\" data-srcset=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png 2560w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-300x175.png 300w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-1024x596.png 1024w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-768x447.png 768w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-1536x894.png 1536w, https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-2048x1192.png 2048w\" data-src=\"https:\/\/nanion.com\/wp-content\/uploads\/2026_WEBSITEthumbanil-CFTR-webinar-scaled.png\"><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Date: November 5, 2026<br \/>\nTime: 16:00 CET | 10:00 a.m. EST | 7:00 a.m. PST<\/p>\n","protected":false},"featured_media":19780,"template":"","news_categories":[528,13],"class_list":["post-19779","news","type-news","status-publish","has-post-thumbnail","hentry","news_categories-front-page-news","news_categories-event"],"acf":[],"_links":{"self":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news\/19779","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news"}],"about":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/types\/news"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media\/19780"}],"wp:attachment":[{"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/media?parent=19779"}],"wp:term":[{"taxonomy":"news_categories","embeddable":true,"href":"https:\/\/nanion.com\/ja\/wp-json\/wp\/v2\/news_categories?post=19779"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}